ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors

ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors

Background: Angiogenesis plays an important role in the survival of tissue, such as blood vessels deliver oxygen and nutrients needed by the cells of the population. Thus, targeting angiogenesis is a prominent strategy in a variety of settings, including both tissue engineering and cancer treatment. However, not all approaches that modulate angiogenesis lead to a successful outcome. angiogenesis based therapies primarily targeting pro-angiogenic factors such as vascular endothelial growth factor-A (VEGF) or fibroblast growth factor (FGF) in isolation, and there is a limited understanding of how these promoters combine together to stimulate angiogenesis. Target one pathway could be enough, because the alternative pathways can compensate, reducing the overall effect of a treatment strategy.


Methods: To gain insight into the mechanistic and identify new therapeutic strategy, we have developed a detailed mathematical models to quantitatively characterize crosstalk of FGF and VEGF intracellular signaling. The model focuses on FGF- and VEGF-induced MAPK (MAPK) signaling to promote cell proliferation and phosphatidylinositol 3-kinase / protein kinase B (PI3K / Akt) pathway, which promotes cell survival and migration. We fit the model for experimental datasets published the size of phosphorylated extracellular regulated kinase (perk) and Akt (pAkt) on FGF or VEGF stimulation. We validate the model with a separate set of data.


Results: We apply mathematical models are trained and validated to characterize the dynamics of Perk and pAkt in response to mono and co-stimulation by FGF and VEGF. The model predicts that for a certain range of ligand concentration, maximum Perk level is more responsive to changes in ligand concentration compared with the maximum level of pAkt. Also, the combination of FGF and VEGF showed a greater effect in increasing the maximum perk than the sum of the individual effects, which are not visible to the maximum pAkt levels. In addition, we identify the model and kinetic parameters affect the species that specifically modulate Perk and pAkt response, which is a potential target for the treatment of angiogenesis-based.


Conclusion: Overall, the model predicts the effect of a combination of FGF and VEGF stimulation on ERK and Akt quantitative and provides a framework for the mechanic to explain experimental results and guide experimental design. Thus, this model can be used to study the effects of the therapy pro- and anti-angiogenic primarily targeting ERK and / or activation of Akt on stimulation with FGF and VEGF. Video Abstract.

 ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors
ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors

TGF-β3 Pressing melanogenesis in cultured human melanocytes with neighboring cells and UV-irradiated human skin

Background: Ultraviolet radiation (UVR) is the most well-known causes of skin pigmentation is accompanied with photoaging. Transforming growth factor (TGF) -β1 shown previously have anti-melanogenic property; However, it can cause scarring in the skin.
Objective: We investigated the effect of TGF-β3 on melanogenesis in cultured human melanocytes in the skin constituent cells UV-irradiated and UV-irradiated human skin.


Methods: UVB radiation or treatment with stem cell factor (SCF) and endothelin-1 (ET-1) was applied to human melanocytes cocultured with keratinocytes and / or fibroblasts and ex vivo human skin. mechanistic pathways are further explored after treatment with TGF-β3.


Results: While UVB radiation or SCF / ET-1 enhanced melanogenesis, TGF-β3 accumulation effectively inhibits melanin and tyrosinase activity through downregulation of extracellular signal-regulated kinase (ERK) / microphthalmia associated transcription factor (MITF) pathway. TGF-β3 increased expression of keratinocyte differentiation markers.

Rat Fibroblast Growth Factor 13 (FGF13) ELISA Kit

DLR-FGF13-Ra-48T 48T
EUR 594
Description: A sandwich quantitative ELISA assay kit for detection of Rat Fibroblast Growth Factor 13 (FGF13) in samples from serum, plasma or other biological fluids.

Rat Fibroblast Growth Factor 13 (FGF13) ELISA Kit

DLR-FGF13-Ra-96T 96T
EUR 772.8
Description: A sandwich quantitative ELISA assay kit for detection of Rat Fibroblast Growth Factor 13 (FGF13) in samples from serum, plasma or other biological fluids.

Human Fibroblast Growth Factor 13 (FGF13) ELISA Kit

RD-FGF13-Hu-48Tests 48 Tests
EUR 552

Human Fibroblast Growth Factor 13 (FGF13) ELISA Kit

RD-FGF13-Hu-96Tests 96 Tests
EUR 763.2

Mouse Fibroblast Growth Factor 13 (FGF13) ELISA Kit

RD-FGF13-Mu-48Tests 48 Tests
EUR 566.4

Mouse Fibroblast Growth Factor 13 (FGF13) ELISA Kit

RD-FGF13-Mu-96Tests 96 Tests
EUR 783.6

Rat Fibroblast Growth Factor 13 (FGF13) ELISA Kit

RD-FGF13-Ra-48Tests 48 Tests
EUR 595.2

Rat Fibroblast Growth Factor 13 (FGF13) ELISA Kit

RD-FGF13-Ra-96Tests 96 Tests
EUR 825.6

Human Fibroblast Growth Factor 13 (FGF13) ELISA Kit

RDR-FGF13-Hu-48Tests 48 Tests
EUR 577.2

Human Fibroblast Growth Factor 13 (FGF13) ELISA Kit

RDR-FGF13-Hu-96Tests 96 Tests
EUR 798

Mouse Fibroblast Growth Factor 13 (FGF13) ELISA Kit

RDR-FGF13-Mu-48Tests 48 Tests
EUR 591.6

Mouse Fibroblast Growth Factor 13 (FGF13) ELISA Kit

RDR-FGF13-Mu-96Tests 96 Tests
EUR 819.6

Rat Fibroblast Growth Factor 13 (FGF13) ELISA Kit

RDR-FGF13-Ra-48Tests 48 Tests
EUR 622.8

Rat Fibroblast Growth Factor 13 (FGF13) ELISA Kit

RDR-FGF13-Ra-96Tests 96 Tests
EUR 864

FGF13 Antibody

CSB-PA151977-
EUR 402
Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

FGF13 Antibody

CSB-PA151977-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

FGF13 Antibody

1-CSB-PA008619ESR1HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

FGF13 Antibody

1-CSB-PA008619ESR2HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

FGF13 Antibody

1-CSB-PA008619GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

FGF13 Antibody

1-CSB-PA008619LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

FGF13 Antibody

1-CSB-PA008241
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

FGF13 Antibody

DF4699 200ul
EUR 420

FGF13 siRNA

20-abx916803
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FGF13 siRNA

20-abx916804
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FGF13 antibody

70R-9323 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal FGF13 antibody

FGF13 antibody

70R-6208 50 ug
EUR 560.4
Description: Rabbit polyclonal FGF13 antibody raised against the middle region of FGF13

FGF13, Peptide

43-178P 0.1 mg
EUR 405.6

FGF13 antibody

70R-17291 50 ul
EUR 522
Description: Rabbit polyclonal FGF13 antibody

FGF13 Antibody

35216-100ul 100ul
EUR 302.4

FGF13 Antibody

35216-50ul 50ul
EUR 224.4

FGF13 Antibody

ABD13096 100 ug
EUR 525.6

FGF13 Antibody

ABD4699 100 ug
EUR 525.6

FGF13 siRNA

20-abx901944
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

anti-FGF13

YF-PA11772 50 ug
EUR 435.6
Description: Mouse polyclonal to FGF13

anti-FGF13

YF-PA11773 100 ug
EUR 483.6
Description: Rabbit polyclonal to FGF13

anti-FGF13

YF-PA23708 50 ul
EUR 400.8
Description: Mouse polyclonal to FGF13

FGF13 Antibody

R34447-100UG 100 ug
EUR 399

FGF13 Rabbit pAb

A7895-100ul 100 ul
EUR 369.6

FGF13 Rabbit pAb

A7895-200ul 200 ul
EUR 550.8

FGF13 Rabbit pAb

A7895-20ul 20 ul
EUR 219.6

FGF13 Rabbit pAb

A7895-50ul 50 ul
EUR 267.6

FGF13 Blocking Peptide

DF4699-BP 1mg
EUR 234

FGF13 Conjugated Antibody

C35216 100ul
EUR 476.4

FGF13 cloning plasmid

CSB-CL008619HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the FGF13 gene.

anti- FGF13 antibody

FNab03090 100µg
EUR 606.3
Description: Antibody raised against FGF13

FGF13 Blocking Peptide

33R-7175 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FGF13 antibody, catalog no. 70R-9323

FGF13 Blocking Peptide

33R-9144 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FGF13 antibody, catalog no. 70R-6208

FGF13 Blocking Peptide

20-abx162114
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Polyclonal FGF13 Antibody

APR05426G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF13 . This antibody is tested and proven to work in the following applications:

Anti-FGF13 Antibody

PA1672 100ug/vial
EUR 352.8

Anti-FGF13 antibody

PAab03090 100 ug
EUR 426

Anti-FGF13 antibody

STJ110204 100 µl
EUR 332.4
Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini.

FGF13 Polyclonal Antibody

A71990-050 50 ul
EUR 302.5

FGF13 Polyclonal Antibody

A71990-100 100 ul
EUR 423.5

FGF13 Polyclonal Antibody

A59126-020 20 ul Ask for price

FGF13 Polyclonal Antibody

A59126-050 50 ul Ask for price

FGF13 Polyclonal Antibody

A59126-100 100 ul
EUR 423.5

FGF13 Polyclonal Antibody

A59126
  • EUR 684.66
  • Ask for price
  • Ask for price
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

FGF13 Polyclonal Antibody

A71990
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

FGF13 Antibody, HRP conjugated

1-CSB-PA008619LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

FGF13 Antibody, FITC conjugated

1-CSB-PA008619LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

FGF13 Antibody, Biotin conjugated

1-CSB-PA008619LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Mouse FGF13 shRNA Plasmid

20-abx970317
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human FGF13 shRNA Plasmid

20-abx951578
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Rat FGF13 shRNA Plasmid

20-abx986958
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

FGF13 (Isoform 1) Antibody

abx431249-200ul 200 ul
EUR 460.8

FGF13 ELISA KIT|Human

EF009617 96 Tests
EUR 826.8

FGF13 ELISA Kit (Rat) (OKCD00187)

OKCD00187 96 Wells
EUR 1075.2
Description: Description of target: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity).By similarity May regulate voltage-gated sodium channels transport and function.By similarity May also play a role in MAPK signaling.By similarity ;Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 5.4 pg/mL

FGF13 ELISA Kit (Human) (OKCD05284)

OKCD05284 96 Wells
EUR 1090.8
Description: Description of target: FGF13 is probably involved in nervous system development and function.The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located to a region associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a syndromal X-linked mental retardation, which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.53pg/mL

Fgf13 ELISA Kit (Mouse) (OKCD01720)

OKCD01720 96 Wells
EUR 1028.4
Description: Description of target: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. Isoform 1 seems not to be involved in neuroblast polarization and migration but regulates axon branching. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling. ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 13.6 pg/mL

Fgf13 ORF Vector (Rat) (pORF)

ORF067093 1.0 ug DNA
EUR 607.2

FGF13 ORF Vector (Human) (pORF)

ORF004034 1.0 ug DNA
EUR 114

Fgf13 ORF Vector (Mouse) (pORF)

ORF044814 1.0 ug DNA
EUR 607.2

Genorise® recombinant Canine FGF13

GR122112 5 µg
EUR 342

Anti-FGF13 (isoform 1) antibody

STJ72910 100 µg
EUR 430.8

FGF13 Polyclonal Antibody, Biotin Conjugated

A59127-050 50 ul
EUR 302.5

FGF13 Polyclonal Antibody, Biotin Conjugated

A59127-100 100 ul
EUR 423.5

FGF13 Polyclonal Antibody, FITC Conjugated

A59128-050 50 ul
EUR 302.5

FGF13 Polyclonal Antibody, FITC Conjugated

A59128-100 100 ul
EUR 423.5

FGF13 Polyclonal Antibody, HRP Conjugated

A59129-050 50 ul
EUR 302.5

FGF13 Polyclonal Antibody, HRP Conjugated

A59129-100 100 ul
EUR 423.5

FGF13 Polyclonal Antibody, Biotin Conjugated

A59127
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

FGF13 Polyclonal Antibody, FITC Conjugated

A59128
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

FGF13 Polyclonal Antibody, HRP Conjugated

A59129
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Human Fibroblast growth factor 13 (FGF13)

1-CSB-EP008619HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Fibroblast growth factor 13(FGF13) expressed in E.coli

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx102845
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx102846
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx102847
  • EUR 1045.20
  • EUR 543.60
  • 1 mg
  • 200 ug

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx102848
  • EUR 543.60
  • EUR 159.60
  • EUR 1562.40
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx172391
  • EUR 410.40
  • EUR 1028.40
  • EUR 526.80
  • EUR 184.80
  • EUR 309.60
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx172392
  • EUR 1095.60
  • EUR 560.40
  • 1 mg
  • 200 ug

Fibroblast Growth Factor 13 (FGF13) Antibody

abx122880-100ug 100 ug
EUR 469.2

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx133405
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx112526
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx007086
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx015081
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Fibroblast Growth Factor 13 (FGF13) Antibody

abx233090-100ug 100 ug
EUR 577.2

Fibroblast Growth Factor 13 (FGF13) Antibody

abx330957-100ul 100 ul
EUR 510

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx320467
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx322715
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx318511
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx327994
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx176406
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx176407
  • EUR 1479.60
  • EUR 710.40
  • 1 mg
  • 200 ug

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx176408
  • EUR 1479.60
  • EUR 710.40
  • 1 mg
  • 200 ug

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx176409
  • EUR 560.40
  • EUR 159.60
  • EUR 1612.80
  • EUR 760.80
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody

20-abx176410
  • EUR 577.20
  • EUR 159.60
  • EUR 1696.80
  • EUR 794.40
  • EUR 427.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Active Fibroblast Growth Factor 13 (FGF13)

4-APC915Ra01
  • EUR 1141.44
  • EUR 429.60
  • EUR 3950.40
  • EUR 1396.80
  • EUR 2673.60
  • EUR 840.00
  • EUR 9696.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Fibroblast Growth Factor 13 expressed in: E.coli

Nori® Equine FGF13 ELISA Kit

GR106699 96-well
EUR 553.2

Nori® Human FGF13 ELISA Kit

GR111234 96-well
EUR 553.2

FGF13 sgRNA CRISPR Lentivector set (Human)

K0778401 3 x 1.0 ug
EUR 406.8

Fgf13 sgRNA CRISPR Lentivector set (Rat)

K7114401 3 x 1.0 ug
EUR 406.8

Fgf13 sgRNA CRISPR Lentivector set (Mouse)

K4392401 3 x 1.0 ug
EUR 406.8

Nori® Rabbit FGF13 ELISA Kit

GR144104 96-well
EUR 553.2

Nori® Monkey FGF13 ELISA Kit

GR169115 96-well
EUR 553.2

Nori® Donkey FGF13 ELISA Kit

GR170115 96-well
EUR 553.2

Nori® Hamster FGF13 ELISA Kit

GR172123 96-well
EUR 553.2

Nori® Feline FGF13 ELISA Kit

GR188123 96-well
EUR 553.2

Genorise® recombinant porcine FGF13 protein

GR189030 5 µg
EUR 342

Nori® Bovine FGF13 ELISA Kit

GR112147 96-well
EUR 553.2

Nori® Porcine FGF13 ELISA Kit

GR113169 96-well
EUR 553.2

Nori® Canine FGF13 ELISA Kit

GR115199 96-well
EUR 553.2

Nori® Ovine FGF13 ELISA Kit

GR116102 96-well
EUR 553.2

Nori® Mouse FGF13 ELISA Kit

GR117120 96-well
EUR 553.2

Nori® Rat FGF13 ELISA Kit

GR118113 96-well
EUR 553.2

Genorise® recombinant human FGF13 protein

GR119099 5 µg
EUR 342

Genorise® recombinant Mouse FGF13 protein

GR124099 5 µg
EUR 342

Recombinant Fibroblast Growth Factor 13 (FGF13)

4-RPC915Hu01
  • EUR 711.36
  • EUR 314.40
  • EUR 2337.60
  • EUR 859.20
  • EUR 1598.40
  • EUR 552.00
  • EUR 5664.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 13 expressed in: E.coli

Recombinant Fibroblast Growth Factor 13 (FGF13)

4-RPC915Hu02
  • EUR 657.60
  • EUR 300.00
  • EUR 2136.00
  • EUR 792.00
  • EUR 1464.00
  • EUR 516.00
  • EUR 5160.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 13 expressed in: E.coli

Recombinant Fibroblast Growth Factor 13 (FGF13)

4-RPC915Ra01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Fibroblast Growth Factor 13 expressed in: E.coli

OVA Conjugated Fibroblast Growth Factor 13 (FGF13)

4-CPC915Hu21
  • EUR 225.37
  • EUR 183.60
  • EUR 515.14
  • EUR 251.71
  • EUR 383.42
  • EUR 225.60
  • EUR 1107.84
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 13 expressed in: chemical synthesis

OVA Conjugated Fibroblast Growth Factor 13 (FGF13)

4-CPC915Mu21
  • EUR 225.37
  • EUR 183.60
  • EUR 515.14
  • EUR 251.71
  • EUR 383.42
  • EUR 225.60
  • EUR 1107.84
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 13 expressed in: chemical synthesis

OVA Conjugated Fibroblast Growth Factor 13 (FGF13)

4-CPC915Ra21
  • EUR 225.37
  • EUR 183.60
  • EUR 515.14
  • EUR 251.71
  • EUR 383.42
  • EUR 225.60
  • EUR 1107.84
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Fibroblast Growth Factor 13 expressed in: chemical synthesis

Human Fibroblast Growth Factor 13 (FGF13) Protein

20-abx066596
  • EUR 978.00
  • EUR 376.80
  • EUR 3133.20
  • EUR 1178.40
  • EUR 693.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Fibroblast Growth Factor 13 (FGF13) Protein

20-abx066597
  • EUR 910.80
  • EUR 360.00
  • EUR 2865.60
  • EUR 1095.60
  • EUR 644.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Fibroblast Growth Factor 13 (FGF13) Protein

20-abx066598
  • EUR 844.80
  • EUR 343.20
  • EUR 2598.00
  • EUR 994.80
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody Pair

20-abx370788
  • EUR 2148.00
  • EUR 1362.00
  • 10 × 96 tests
  • 5 × 96 tests

Fibroblast Growth Factor 13 (FGF13) Antibody Pair

20-abx370795
  • EUR 2264.40
  • EUR 1429.20
  • 10 × 96 tests
  • 5 × 96 tests

Mouse Fibroblast Growth Factor 13 (FGF13) Protein

20-abx653377
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Fibroblast Growth Factor 13 (FGF13) Protein

20-abx653378
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody (FITC)

20-abx273620
  • EUR 577.20
  • EUR 292.80
  • EUR 1696.80
  • EUR 794.40
  • EUR 427.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody (HRP)

20-abx303856
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody (FITC)

20-abx303857
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody (Biotin)

20-abx303858
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 13 (FGF13) Antibody (Biotin)

20-abx272303
  • EUR 543.60
  • EUR 292.80
  • EUR 1579.20
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Polyclonal FGF13 (isoform 1) Antibody (internal region)

APG00862G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human FGF13 (isoform 1) (internal region). This antibody is tested and proven to work in the following applications:

FGF13 Chemi-Luminescent ELISA Kit (Rat) (OKCD03468)

OKCD03468 96 Wells
EUR 1279.2
Description: Description of target: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus .;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.63 pg/mL

FGF13 Chemi-Luminescent ELISA Kit (Mouse) (OKCD03469)

OKCD03469 96 Wells
EUR 1232.4
Description: Description of target: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. Isoform 1 seems not to be involved in neuroblast polarization and migration but regulates axon branching. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling. ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 31.25 pg/mL

FGF13 Chemi-Luminescent ELISA Kit (Human) (OKCD05584)

OKCD05584 96 Wells
EUR 1263.6
Description: Description of target: FGF13 is probably involved in nervous system development and function.The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located to a region associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a syndromal X-linked mental retardation, which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.28pg/mL

FGF13 sgRNA CRISPR Lentivector (Human) (Target 1)

K0778402 1.0 ug DNA
EUR 184.8

FGF13 sgRNA CRISPR Lentivector (Human) (Target 2)

K0778403 1.0 ug DNA
EUR 184.8

FGF13 sgRNA CRISPR Lentivector (Human) (Target 3)

K0778404 1.0 ug DNA
EUR 184.8

Fgf13 sgRNA CRISPR Lentivector (Rat) (Target 1)

K7114402 1.0 ug DNA
EUR 184.8

Fgf13 sgRNA CRISPR Lentivector (Rat) (Target 2)

K7114403 1.0 ug DNA
EUR 184.8

Fgf13 sgRNA CRISPR Lentivector (Rat) (Target 3)

K7114404 1.0 ug DNA
EUR 184.8

Fgf13 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4392402 1.0 ug DNA
EUR 184.8

Fgf13 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4392403 1.0 ug DNA
EUR 184.8

Fgf13 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4392404 1.0 ug DNA
EUR 184.8

Nori® Guinea Pig FGF13 ELISA Kit

GR171114 96-well
EUR 553.2

FGF13 Protein Vector (Human) (pPB-C-His)

PV016133 500 ng
EUR 394.8

FGF13 Protein Vector (Human) (pPB-N-His)

PV016134 500 ng
EUR 394.8

FGF13 Protein Vector (Human) (pPM-C-HA)

PV016135 500 ng
EUR 394.8

FGF13 Protein Vector (Human) (pPM-C-His)

PV016136 500 ng
EUR 394.8

FGF13 Protein Vector (Rat) (pPB-C-His)

PV268370 500 ng
EUR 723.6

FGF13 Protein Vector (Rat) (pPB-N-His)

PV268371 500 ng
EUR 723.6

FGF13 Protein Vector (Rat) (pPM-C-HA)

PV268372 500 ng
EUR 723.6

FGF13 Protein Vector (Rat) (pPM-C-His)

PV268373 500 ng
EUR 723.6

FGF13 Protein Vector (Mouse) (pPB-C-His)

PV179254 500 ng
EUR 723.6

FGF13 Protein Vector (Mouse) (pPB-N-His)

PV179255 500 ng
EUR 723.6

FGF13 Protein Vector (Mouse) (pPM-C-HA)

PV179256 500 ng
EUR 723.6

FGF13 Protein Vector (Mouse) (pPM-C-His)

PV179257 500 ng
EUR 723.6

Fgf13 3'UTR Luciferase Stable Cell Line

TU204598 1.0 ml Ask for price

Fgf13 3'UTR GFP Stable Cell Line

TU254598 1.0 ml Ask for price

Fgf13 3'UTR GFP Stable Cell Line

TU156532 1.0 ml Ask for price

Fgf13 3'UTR Luciferase Stable Cell Line

TU106532 1.0 ml Ask for price

FGF13 3'UTR GFP Stable Cell Line

TU057927 1.0 ml
EUR 1672.8

FGF13 3'UTR Luciferase Stable Cell Line

TU007927 1.0 ml
EUR 1672.8

Human Fibroblast Growth Factor 13 (FGF13)CLIA Kit

CCC915Hu-10x96wellstestplate 10x96-wells test plate
EUR 6777.36
Description: This is Competitive Chemiluminescent immunoassay for detection of Human Fibroblast Growth Factor 13 (FGF13) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Fibroblast Growth Factor 13 (FGF13)CLIA Kit

CCC915Hu-1x48wellstestplate 1x48-wells test plate
EUR 663.31
Description: This is Competitive Chemiluminescent immunoassay for detection of Human Fibroblast Growth Factor 13 (FGF13) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Fibroblast Growth Factor 13 (FGF13)CLIA Kit

CCC915Hu-1x96wellstestplate 1x96-wells test plate
EUR 896.16
Description: This is Competitive Chemiluminescent immunoassay for detection of Human Fibroblast Growth Factor 13 (FGF13) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Fibroblast Growth Factor 13 (FGF13)CLIA Kit

CCC915Hu-5x96wellstestplate 5x96-wells test plate
EUR 3672.72
Description: This is Competitive Chemiluminescent immunoassay for detection of Human Fibroblast Growth Factor 13 (FGF13) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Fibroblast Growth Factor 13 (FGF13) CLIA Kit

4-CCC915Hu
  • EUR 6837.60
  • EUR 3673.20
  • EUR 896.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Fibroblast Growth Factor 13 (FGF13)serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids

Human Fibroblast Growth Factor 13 (FGF13) ELISA Kit

CEC915Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Fibroblast Growth Factor 13 (FGF13) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Fibroblast Growth Factor 13 (FGF13) ELISA Kit

CEC915Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Fibroblast Growth Factor 13 (FGF13) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Fibroblast Growth Factor 13 (FGF13) ELISA Kit

CEC915Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Fibroblast Growth Factor 13 (FGF13) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Fibroblast Growth Factor 13 (FGF13) ELISA Kit

CEC915Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Fibroblast Growth Factor 13 (FGF13) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Fibroblast Growth Factor 13 (FGF13) ELISA Kit

4-CEC915Hu
  • EUR 5738.40
  • EUR 3031.20
  • EUR 768.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Fibroblast Growth Factor 13 (FGF13) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Rat Fibroblast Growth Factor 13 (FGF13) ELISA Kit

20-abx155514
  • EUR 8684.40
  • EUR 4626.00
  • EUR 1074.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Fibroblast Growth Factor 13 (FGF13) ELISA Kit

20-abx151516
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Fibroblast Growth Factor 13 (FGF13) ELISA Kit

20-abx154001
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests


Conclusion:
TGF-β3 effectively suppressed UVR-induced melanogenesis showed that topical TGF-β3 may be a suitable candidate for the treatment of hyperpigmentation, UV-related disorders.

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