ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors
Background: Angiogenesis plays an important role in the survival of tissue, such as blood vessels deliver oxygen and nutrients needed by the cells of the population. Thus, targeting angiogenesis is a prominent strategy in a variety of settings, including both tissue engineering and cancer treatment. However, not all approaches that modulate angiogenesis lead to a successful outcome. angiogenesis based therapies primarily targeting pro-angiogenic factors such as vascular endothelial growth factor-A (VEGF) or fibroblast growth factor (FGF) in isolation, and there is a limited understanding of how these promoters combine together to stimulate angiogenesis. Target one pathway could be enough, because the alternative pathways can compensate, reducing the overall effect of a treatment strategy.
Methods: To gain insight into the mechanistic and identify new therapeutic strategy, we have developed a detailed mathematical models to quantitatively characterize crosstalk of FGF and VEGF intracellular signaling. The model focuses on FGF- and VEGF-induced MAPK (MAPK) signaling to promote cell proliferation and phosphatidylinositol 3-kinase / protein kinase B (PI3K / Akt) pathway, which promotes cell survival and migration. We fit the model for experimental datasets published the size of phosphorylated extracellular regulated kinase (perk) and Akt (pAkt) on FGF or VEGF stimulation. We validate the model with a separate set of data.
Results: We apply mathematical models are trained and validated to characterize the dynamics of Perk and pAkt in response to mono and co-stimulation by FGF and VEGF. The model predicts that for a certain range of ligand concentration, maximum Perk level is more responsive to changes in ligand concentration compared with the maximum level of pAkt. Also, the combination of FGF and VEGF showed a greater effect in increasing the maximum perk than the sum of the individual effects, which are not visible to the maximum pAkt levels. In addition, we identify the model and kinetic parameters affect the species that specifically modulate Perk and pAkt response, which is a potential target for the treatment of angiogenesis-based.
Conclusion: Overall, the model predicts the effect of a combination of FGF and VEGF stimulation on ERK and Akt quantitative and provides a framework for the mechanic to explain experimental results and guide experimental design. Thus, this model can be used to study the effects of the therapy pro- and anti-angiogenic primarily targeting ERK and / or activation of Akt on stimulation with FGF and VEGF. Video Abstract.
TGF-β3 Pressing melanogenesis in cultured human melanocytes with neighboring cells and UV-irradiated human skin
Background: Ultraviolet radiation (UVR) is the most well-known causes of skin pigmentation is accompanied with photoaging. Transforming growth factor (TGF) -β1 shown previously have anti-melanogenic property; However, it can cause scarring in the skin.
Objective: We investigated the effect of TGF-β3 on melanogenesis in cultured human melanocytes in the skin constituent cells UV-irradiated and UV-irradiated human skin.
Methods: UVB radiation or treatment with stem cell factor (SCF) and endothelin-1 (ET-1) was applied to human melanocytes cocultured with keratinocytes and / or fibroblasts and ex vivo human skin. mechanistic pathways are further explored after treatment with TGF-β3.
Results: While UVB radiation or SCF / ET-1 enhanced melanogenesis, TGF-β3 accumulation effectively inhibits melanin and tyrosinase activity through downregulation of extracellular signal-regulated kinase (ERK) / microphthalmia associated transcription factor (MITF) pathway. TGF-β3 increased expression of keratinocyte differentiation markers.
FGF13 siRNA |
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20-abx901944 | Abbexa |
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FGF13, Peptide |
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43-178P | ProSci | 0.1 mg | EUR 405.6 |
FGF13 Antibody |
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35216 | SAB | 100ul | EUR 319 |
FGF13 Antibody |
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35216-100ul | SAB | 100ul | EUR 302.4 |
FGF13 Antibody |
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35216-50ul | SAB | 50ul | EUR 224.4 |
FGF13 Antibody |
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E035216 | EnoGene | 100μg/100μl | EUR 255 |
Description: Available in various conjugation types. |
FGF13 Antibody |
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E19-4699 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
FGF13 Antibody |
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E11-20772C | EnoGene | 100μg | EUR 225 |
Description: Available in various conjugation types. |
FGF13 Antibody |
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E93861 | EnoGene | 100μg | EUR 255 |
Description: Available in various conjugation types. |
FGF13 Antibody |
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DF4699 | Affbiotech | 200ul | EUR 420 |
FGF13 Antibody |
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DF4699-100ul | Affinity Biosciences | 100ul | EUR 280 |
FGF13 Antibody |
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DF4699-200ul | Affinity Biosciences | 200ul | EUR 350 |
FGF13 Antibody |
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E306653 | EnoGene | 200ul | EUR 275 |
Description: Available in various conjugation types. |
FGF13 Antibody |
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E38PA4903 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
FGF13 Antibody |
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1-CSB-PA008241 | Cusabio |
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Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000 |
FGF13 Antibody |
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1-CSB-PA008619ESR1HU | Cusabio |
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Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200 |
FGF13 Antibody |
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1-CSB-PA008619ESR2HU | Cusabio |
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Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
FGF13 Antibody |
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1-CSB-PA008619GA01HU | Cusabio |
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Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC |
FGF13 Antibody |
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1-CSB-PA008619LA01HU | Cusabio |
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Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 |
FGF13 antibody |
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70R-17291 | Fitzgerald | 50 ul | EUR 289 |
Description: Rabbit polyclonal FGF13 antibody |
FGF13 antibody |
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70R-9323 | Fitzgerald | 50 ug | EUR 467 |
Description: Affinity purified rabbit polyclonal FGF13 antibody |
FGF13 antibody |
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70R-6208 | Fitzgerald | 50 ug | EUR 467 |
Description: Rabbit polyclonal FGF13 antibody raised against the middle region of FGF13 |
FGF13 Antibody |
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ABD13096 | Lifescience Market | 100 ug | EUR 525.6 |
FGF13 Antibody |
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ABD4699 | Lifescience Market | 100 ug | EUR 525.6 |
FGF13 Antibody |
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CAC08436-100ug | Biomatik Corporation | 100ug | EUR 314 |
FGF13 Antibody |
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CAC08436-50ug | Biomatik Corporation | 50ug | EUR 199.2 |
FGF13 Antibody |
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CSB-PA151977- | Cusabio | each | EUR 402 |
Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000 |
FGF13 Antibody |
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CSB-PA151977-100ul | Cusabio | 100ul | EUR 379.2 |
Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000 |
FGF13 Antibody |
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GWB-MT832D | GenWay Biotech | 50ug | Ask for price |
FGF13 Antibody |
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GWB-MT833E | GenWay Biotech | 50ug | Ask for price |
FGF13 Antibody |
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R34447-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: Fibroblast growth factor 13 |
FGF13 Rabbit pAb |
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E2507895 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
FGF13 Rabbit pAb |
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A7895-100ul | Abclonal | 100 ul | EUR 369.6 |
FGF13 Rabbit pAb |
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A7895-200ul | Abclonal | 200 ul | EUR 550.8 |
FGF13 Rabbit pAb |
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A7895-20ul | Abclonal | 20 ul | EUR 219.6 |
FGF13 Rabbit pAb |
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A7895-50ul | Abclonal | 50 ul | EUR 267.6 |
anti- FGF13 antibody |
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FNab03090 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against FGF13 |
Fgf13 (untagged) - Mouse fibroblast growth factor 13 (Fgf13), (10ug) |
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MC208481 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 cloning plasmid |
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CSB-CL008619HU-10ug | Cusabio | 10ug | EUR 279.6 |
Description: A cloning plasmid for the FGF13 gene. |
FGF13 Blocking Peptide |
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33R-7175 | Fitzgerald | 100 ug | EUR 119 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FGF13 antibody, catalog no. 70R-9323 |
FGF13 Blocking Peptide |
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33R-9144 | Fitzgerald | 100 ug | EUR 119 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FGF13 antibody, catalog no. 70R-6208 |
FGF13 Blocking Peptide |
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DF4699-BP | Affbiotech | 1mg | EUR 234 |
FGF13 Blocking Peptide |
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20-abx162114 | Abbexa |
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FGF13 Polyclonal Antibody |
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E97895 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
FGF13 Polyclonal Antibody |
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A59126 | EpiGentek |
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Polyclonal FGF13 Antibody |
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APR05426G | Leading Biology | 0.1ml | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF13 . This antibody is tested and proven to work in the following applications: |
FGF13 Conjugated Antibody |
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C35216 | SAB | 100ul | EUR 476.4 |
FGF13 Polyclonal Antibody |
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A71990 | EpiGentek | 50 μl | EUR 408 |
FGF13 Polyclonal Antibody |
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E-AB-19868-120uL | Elabscience Biotech | 120uL | EUR 240 |
Description: Unconjugated |
FGF13 Polyclonal Antibody |
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E-AB-19868-200uL | Elabscience Biotech | 200uL | EUR 399 |
Description: Unconjugated |
FGF13 Polyclonal Antibody |
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E-AB-19868-20uL | Elabscience Biotech | 20uL | EUR 73 |
Description: Unconjugated |
FGF13 Polyclonal Antibody |
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E-AB-19868-60uL | Elabscience Biotech | 60uL | EUR 143 |
Description: Unconjugated |
FGF13 Polyclonal Antibody |
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E-AB-62743-120uL | Elabscience Biotech | 120uL | EUR 320 |
Description: Unconjugated |
FGF13 Polyclonal Antibody |
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E-AB-62743-200uL | Elabscience Biotech | 200uL | EUR 530 |
Description: Unconjugated |
FGF13 Polyclonal Antibody |
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E-AB-62743-60uL | Elabscience Biotech | 60uL | EUR 200 |
Description: Unconjugated |
FGF13 Polyclonal Antibody |
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E-AB-62743-each | Elabscience Biotech | each | Ask for price |
Description: Unconjugated |
FGF13 Polyclonal Antibody |
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E-AB-17962-120uL | Elabscience Biotech | 120uL | EUR 240 |
Description: Unconjugated |
FGF13 Polyclonal Antibody |
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E-AB-17962-200uL | Elabscience Biotech | 200uL | EUR 399 |
Description: Unconjugated |
FGF13 Polyclonal Antibody |
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E-AB-17962-20uL | Elabscience Biotech | 20uL | EUR 73 |
Description: Unconjugated |
FGF13 Polyclonal Antibody |
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E-AB-17962-60uL | Elabscience Biotech | 60uL | EUR 143 |
Description: Unconjugated |
Fgf13 (GFP-tagged) - Mouse fibroblast growth factor 13 (Fgf13), (10ug) |
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MG221854 | Origene Technologies GmbH | 10 µg | Ask for price |
Fgf13 (Myc-DDK-tagged) - Mouse fibroblast growth factor 13 (Fgf13) |
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MR221854 | Origene Technologies GmbH | 10 µg | Ask for price |
Fgf13 (untagged ORF) - Rat fibroblast growth factor 13 (Fgf13), (10 ug) |
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RN201615 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 ELISA KIT|Human |
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EF009617 | Lifescience Market | 96 Tests | EUR 826.8 |
Rat FGF13 shRNA Plasmid |
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20-abx986958 | Abbexa |
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Human FGF13 shRNA Plasmid |
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20-abx951578 | Abbexa |
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FGF13 (Isoform 1) Antibody |
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abx431249-200ul | Abbexa | 200 ul | EUR 460.8 |
Mouse FGF13 shRNA Plasmid |
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20-abx970317 | Abbexa |
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FGF13 (Isoform 1) Antibody |
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abx431249-200l | Abbexa | 200 µl | EUR 387.5 |
FGF13 (untagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 4 |
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SC325591 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (untagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 3 |
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SC325627 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (untagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 5 |
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SC325628 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (untagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 2 |
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SC325675 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (untagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 1 |
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SC109226 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (untagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 6 |
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SC305664 | Origene Technologies GmbH | 10 µg | Ask for price |
Fgf13 (untagged) - Mouse fibroblast growth factor 13 (Fgf13), transcript variant 3 |
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MC226197 | Origene Technologies GmbH | 10 µg | Ask for price |
Fgf13 (untagged) - Mouse fibroblast growth factor 13 (Fgf13), transcript variant 2 |
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MC226608 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (untagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 1 |
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SC320392 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 Antibody, HRP conjugated |
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1-CSB-PA008619LB01HU | Cusabio |
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Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
FGF13 Antibody, FITC conjugated |
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1-CSB-PA008619LC01HU | Cusabio |
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Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
OACD03502-1ML - FGF13 Antibody |
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OACD03502-1ML | Aviva Systems Biology | 1ml | EUR 669 |
OACD03503-1ML - FGF13 Antibody |
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OACD03503-1ML | Aviva Systems Biology | 1ml | EUR 669 |
OACD03504-1ML - FGF13 Antibody |
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OACD03504-1ML | Aviva Systems Biology | 1ml | EUR 729 |
OACA07424-50UL - FGF13 Antibody |
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OACA07424-50UL | Aviva Systems Biology | 50ul | EUR 189 |
OACA07425-50UL - FGF13 Antibody |
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OACA07425-50UL | Aviva Systems Biology | 50ul | EUR 189 |
OAAN02496-50UL - FGF13 Antibody |
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OAAN02496-50UL | Aviva Systems Biology | 50ul | EUR 149 |
OACA02969-50UG - FGF13 Antibody |
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OACA02969-50UG | Aviva Systems Biology | 50ug | EUR 179 |
FGF13 Antibody, Biotin conjugated |
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1-CSB-PA008619LD01HU | Cusabio |
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Description: A polyclonal antibody against FGF13. Recognizes FGF13 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
FGF13 Rabbit Polyclonal Antibody |
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55362 | SAB | 100ul | EUR 439 |
OACA07424-100UL - FGF13 Antibody |
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OACA07424-100UL | Aviva Systems Biology | 100ul | EUR 230 |
OACA07425-100UL - FGF13 Antibody |
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OACA07425-100UL | Aviva Systems Biology | 100ul | EUR 230 |
OAGA01439-100UL - FGF13 Antibody |
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OAGA01439-100UL | Aviva Systems Biology | 100ul | EUR 369 |
OAAN02496-100UL - FGF13 Antibody |
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OAAN02496-100UL | Aviva Systems Biology | 100ul | EUR 249 |
OAAN02496-200UL - FGF13 Antibody |
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OAAN02496-200UL | Aviva Systems Biology | 200ul | EUR 389 |
OACA02969-100UG - FGF13 Antibody |
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OACA02969-100UG | Aviva Systems Biology | 100ug | EUR 319 |
OACD03502-100UL - FGF13 Antibody |
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OACD03502-100UL | Aviva Systems Biology | 100ul | EUR 199 |
OACD03503-100UL - FGF13 Antibody |
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OACD03503-100UL | Aviva Systems Biology | 100ul | EUR 199 |
OACD03504-100UL - FGF13 Antibody |
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OACD03504-100UL | Aviva Systems Biology | 100ul | EUR 209 |
FGF13 Rabbit Polyclonal Antibody |
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E10G06520 | EnoGene | 100 μl | EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
FGF13 Rabbit Polyclonal Antibody |
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E10G13411 | EnoGene | 100 μl | EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
FGF13 Rabbit Polyclonal Antibody |
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E10G13770 | EnoGene | 100 μl | EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
FGF13 Rabbit Polyclonal Antibody |
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E10G06884 | EnoGene | 100 μl | EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
FGF13 (GFP-tagged) - Human fibroblast growth factor 13 (FGF13), transcript variant 6 |
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RG217121 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (GFP-tagged) - Human fibroblast growth factor 13 (FGF13), transcript variant 1 |
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RG204164 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (GFP-tagged) - Human fibroblast growth factor 13 (FGF13), transcript variant 4 |
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RG227490 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (GFP-tagged) - Human fibroblast growth factor 13 (FGF13), transcript variant 2 |
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RG227498 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (GFP-tagged) - Human fibroblast growth factor 13 (FGF13), transcript variant 3 |
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RG227509 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (GFP-tagged) - Human fibroblast growth factor 13 (FGF13), transcript variant 5 |
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RG227518 | Origene Technologies GmbH | 10 µg | Ask for price |
Fgf13 (Myc-DDK-tagged ORF) - Rat fibroblast growth factor 13 (Fgf13), (10 ug) |
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RR201615 | Origene Technologies GmbH | 10 µg | Ask for price |
Fgf13 ORF Vector (Rat) (pORF) |
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ORF067093 | ABM | 1.0 ug DNA | EUR 607.2 |
Fgf13 ORF Vector (Mouse) (pORF) |
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ORF044814 | ABM | 1.0 ug DNA | EUR 607.2 |
FGF13 ORF Vector (Human) (pORF) |
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ORF004034 | ABM | 1.0 ug DNA | EUR 114 |
Lenti ORF clone of Fgf13 (mGFP-tagged) - Mouse fibroblast growth factor 13 (Fgf13) |
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MR221854L4 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 ELISA Kit (Rat) (OKCD00187) |
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OKCD00187 | Aviva Systems Biology | 96 Wells | EUR 1075.2 |
Description: Description of target: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity).By similarity May regulate voltage-gated sodium channels transport and function.By similarity May also play a role in MAPK signaling.By similarity ;Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 5.4 pg/mL |
Human FGF13 knockout cell line |
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ABC-KH5509 | AcceGen | 1 vial | Ask for price |
Description: Human FGF13 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology. |
Human FGF13 knockdown cell line |
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ABC-KD5509 | AcceGen | 1 vial | Ask for price |
Description: Human FGF13 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest. |
Human FGF13 Protein Lysate 20ug |
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IHUFGF13PLLY20UG | Innovative research | each | EUR 213 |
Description: Human FGF13 Protein Lysate 20ug |
FGF13 ELISA Kit (Human) (OKCD05284) |
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OKCD05284 | Aviva Systems Biology | 96 Wells | EUR 1090.8 |
Description: Description of target: FGF13 is probably involved in nervous system development and function.The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located to a region associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a syndromal X-linked mental retardation, which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.53pg/mL |
Fgf13 ELISA Kit (Mouse) (OKCD01720) |
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OKCD01720 | Aviva Systems Biology | 96 Wells | EUR 1028.4 |
Description: Description of target: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. Isoform 1 seems not to be involved in neuroblast polarization and migration but regulates axon branching. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling. ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 13.6 pg/mL |
FGF13 (Myc-DDK-tagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 4 |
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RC227490 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (Myc-DDK-tagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 2 |
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RC227498 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (Myc-DDK-tagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 3 |
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RC227509 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (Myc-DDK-tagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 5 |
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RC227518 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (Myc-DDK-tagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 1 |
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RC204164 | Origene Technologies GmbH | 10 µg | Ask for price |
Fgf13 (myc-DDK-tagged) - Mouse fibroblast growth factor 13 (Fgf13), transcript variant 3 |
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MR228408 | Origene Technologies GmbH | 10 µg | Ask for price |
Fgf13 (myc-DDK-tagged) - Mouse fibroblast growth factor 13 (Fgf13), transcript variant 2 |
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MR228819 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 (Myc-DDK-tagged)-Human fibroblast growth factor 13 (FGF13), transcript variant 6 |
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RC217121 | Origene Technologies GmbH | 10 µg | Ask for price |
Genorise® recombinant Canine FGF13 |
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GR122112 | Genorise Scientific | 5 µg | EUR 285 |
OCOA13267-20UG - FGF13 Protein Lysate |
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OCOA13267-20UG | Aviva Systems Biology | 20ug | EUR 169 |
OCOA07053-20UG - FGF13 Protein Lysate |
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OCOA07053-20UG | Aviva Systems Biology | 20ug | EUR 169 |
FGF13 Over-expression Lysate Product |
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GWB-3A473B | GenWay Biotech | 0.1 mg | Ask for price |
ARP90557_P050 - Fgf13 Antibody Middle region |
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ARP90557_P050 | Aviva Systems Biology | 100ul | EUR 389 |
FGF13 Polyclonal Antibody, HRP Conjugated |
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A59129 | EpiGentek |
|
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Lenti ORF clone of Fgf13 (Myc-DDK-tagged) - Mouse fibroblast growth factor 13 (Fgf13) |
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MR221854L3 | Origene Technologies GmbH | 10 µg | Ask for price |
FGF13 Polyclonal Antibody, FITC Conjugated |
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A59128 | EpiGentek |
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OPCA03132-1MG - FGF13 Recombinant Protein |
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OPCA03132-1MG | Aviva Systems Biology | 1mg | EUR 1379 |
OPCD03190-10UG - FGF13 Recombinant Protein |
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OPCD03190-10UG | Aviva Systems Biology | 10ug | EUR 159 |
OPCD03190-50UG - FGF13 Recombinant Protein |
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OPCD03190-50UG | Aviva Systems Biology | 50ug | EUR 389 |
OPCD03191-10UG - FGF13 Recombinant Protein |
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OPCD03191-10UG | Aviva Systems Biology | 10ug | EUR 179 |
OPCD03191-50UG - FGF13 Recombinant Protein |
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OPCD03191-50UG | Aviva Systems Biology | 50ug | EUR 429 |
OPCD03192-10UG - FGF13 Recombinant Protein |
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OPCD03192-10UG | Aviva Systems Biology | 10ug | EUR 139 |
OPCD03192-50UG - FGF13 Recombinant Protein |
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OPCD03192-50UG | Aviva Systems Biology | 50ug | EUR 349 |
OPCA03132-20UG - FGF13 Recombinant Protein |
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OPCA03132-20UG | Aviva Systems Biology | 20ug | EUR 218 |
FGF13 Polyclonal Antibody, Biotin Conjugated |
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A59127 | EpiGentek |
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OPCD03190-200UG - FGF13 Recombinant Protein |
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OPCD03190-200UG | Aviva Systems Biology | 200ug | EUR 779 |
OPCD03191-200UG - FGF13 Recombinant Protein |
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OPCD03191-200UG | Aviva Systems Biology | 200ug | EUR 859 |
OPCD03192-200UG - FGF13 Recombinant Protein |
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OPCD03192-200UG | Aviva Systems Biology | 200ug | EUR 699 |
OPCA03132-100UG - FGF13 Recombinant Protein |
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OPCA03132-100UG | Aviva Systems Biology | 100ug | EUR 323 |
Nori® Rat FGF13 ELISA Kit |
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GR118113 | Genorise Scientific | 96-well | EUR 461 |
Nori® Ovine FGF13 ELISA Kit |
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GR116102 | Genorise Scientific | 96-well | EUR 461 |
Nori® Mouse FGF13 ELISA Kit |
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GR117120 | Genorise Scientific | 96-well | EUR 461 |
Nori® Human FGF13 ELISA Kit |
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GR111234 | Genorise Scientific | 96-well | EUR 461 |
Nori® Monkey FGF13 ELISA Kit |
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GR169115 | Genorise Scientific | 96-well | EUR 461 |
Nori® Donkey FGF13 ELISA Kit |
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GR170115 | Genorise Scientific | 96-well | EUR 461 |
Nori® Feline FGF13 ELISA Kit |
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GR188123 | Genorise Scientific | 96-well | EUR 461 |
Nori® Canine FGF13 ELISA Kit |
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GR115199 | Genorise Scientific | 96-well | EUR 461 |
Nori® Bovine FGF13 ELISA Kit |
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GR112147 | Genorise Scientific | 96-well | EUR 461 |
Nori® Equine FGF13 ELISA Kit |
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GR106699 | Genorise Scientific | 96-well | EUR 461 |
Nori® Rabbit FGF13 ELISA Kit |
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GR144104 | Genorise Scientific | 96-well | EUR 461 |
Nori® Hamster FGF13 ELISA Kit |
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GR172123 | Genorise Scientific | 96-well | EUR 461 |
Nori® Porcine FGF13 ELISA Kit |
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GR113169 | Genorise Scientific | 96-well | EUR 461 |
OKCD00187-96W - FGF13 ELISA Kit (Rat) |
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OKCD00187-96W | Aviva Systems Biology | 96Wells | EUR 725 |
OKCD05284-96W - FGF13 ELISA Kit (Human) |
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OKCD05284-96W | Aviva Systems Biology | 96Wells | EUR 750 |
OKCD01720-96W - Fgf13 ELISA Kit (Mouse) |
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OKCD01720-96W | Aviva Systems Biology | 96Wells | EUR 700 |
Fgf13 sgRNA CRISPR Lentivector set (Rat) |
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K7114401 | ABM | 3 x 1.0 ug | EUR 406.8 |
Human Fibroblast growth factor 13 (FGF13) |
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1-CSB-EP008619HU | Cusabio |
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Description: Recombinant Human Fibroblast growth factor 13(FGF13) expressed in E.coli |
Lenti ORF clone of Fgf13 (mGFP-tagged ORF) - Rat fibroblast growth factor 13 (Fgf13), (10 ug) |
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RR201615L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Active Fibroblast Growth Factor 13 (FGF13) |
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APC915Hu02 | Cloud-Clone | 10ug | EUR 330 |
Active Fibroblast Growth Factor 13 (FGF13) |
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APC915Ra01 | Cloud-Clone | 10ug | EUR 380 |
Active Fibroblast Growth Factor 13 (FGF13) |
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4-APC915Ra01 | Cloud-Clone |
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Description: Recombinant Rat Fibroblast Growth Factor 13 expressed in: E.coli |
Fgf13 sgRNA CRISPR Lentivector set (Mouse) |
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K4392401 | ABM | 3 x 1.0 ug | EUR 406.8 |
Active Fibroblast Growth Factor 13 (FGF13) |
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RPU59224-100ug | Biomatik Corporation | 100ug | EUR 1089 |
Active Fibroblast Growth Factor 13 (FGF13) |
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RPU59224-1mg | Biomatik Corporation | 1mg | EUR 4826.3 |
Active Fibroblast Growth Factor 13 (FGF13) |
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RPU59224-50ug | Biomatik Corporation | 50ug | EUR 726 |
Active Fibroblast Growth Factor 13 (FGF13) |
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RPU59275-100ug | Biomatik Corporation | 100ug | EUR 1306.8 |
Active Fibroblast Growth Factor 13 (FGF13) |
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RPU59275-1mg | Biomatik Corporation | 1mg | EUR 5791.5 |
Active Fibroblast Growth Factor 13 (FGF13) |
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RPU59275-50ug | Biomatik Corporation | 50ug | EUR 871.2 |
Active Fibroblast Growth Factor 13 (FGF13) |
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RPU54958-100ug | Biomatik Corporation | 100ug | EUR 1170.4 |
Active Fibroblast Growth Factor 13 (FGF13) |
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RPU54958-1mg | Biomatik Corporation | 1mg | EUR 5187 |
Active Fibroblast Growth Factor 13 (FGF13) |
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RPU54958-50ug | Biomatik Corporation | 50ug | EUR 940.5 |
FGF13 sgRNA CRISPR Lentivector set (Human) |
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K0778401 | ABM | 3 x 1.0 ug | EUR 406.8 |
Fibroblast Growth Factor 13 (FGF13) Antibody |
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20-abx322715 | Abbexa |
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Fibroblast Growth Factor 13 (FGF13) Antibody |
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20-abx318511 | Abbexa |
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Fibroblast Growth Factor 13 (FGF13) Antibody |
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20-abx327994 | Abbexa |
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Fibroblast Growth Factor 13 (FGF13) Antibody |
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20-abx320467 | Abbexa |
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Fibroblast Growth Factor 13 (FGF13) Antibody |
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abx330957-100ul | Abbexa | 100 ul | EUR 510 |
Fibroblast Growth Factor 13 (FGF13) Antibody |
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20-abx176406 | Abbexa |
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Fibroblast Growth Factor 13 (FGF13) Antibody |
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20-abx176407 | Abbexa |
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Fibroblast Growth Factor 13 (FGF13) Antibody |
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20-abx176408 | Abbexa |
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Fibroblast Growth Factor 13 (FGF13) Antibody |
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20-abx176409 | Abbexa |
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Conclusion: TGF-β3 effectively suppressed UVR-induced melanogenesis showed that topical TGF-β3 may be a suitable candidate for the treatment of hyperpigmentation, UV-related disorders.