FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer

FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer

Fibroblast growth factor receptor 4 (FGFR4) is known to induce cancer cell proliferation, invasion, and anti-apoptosis through activation of the RAS / RAF / ERK and PI3K / pathways AKT, also known as the molecular basis primary carcinogenesis of colon cancer associated with EGFR signaling. However, the interaction of FGFR4 and EGFR signal with respect to the development of colon cancer is not clear.

Here, we investigated the potential crosstalk between FGFR4 and EGFR, and the effect of anti-EGFR therapy in the treatment of colon cancer. To explore the biological role of FGFR4 in cancer development, RNA-seq is done by using a colon cell line transfected FGFR4. Gene ontology data showed upregulation of genes related to EGFR signaling and we identified that the secret of FGFR4 excess EGFR ligands such as AREG with the activation of EGFR and erbB3 result. These results also demonstrated in vivo study and cooperative interaction of EGFR and FGFR4 promoted tumor growth. In addition, reduced excess FGFR4 cetuximab-induced cytotoxicity and FGFR4 inhibitor combinations (BLU9931) and cetuximab showed profound antitumor effect of cetuximab alone.

Clinically, we found a positive correlation between FGFR4 and AREG expression in tumor tissue but not in normal tissue of the colon cancer patients and these expressions were significantly correlated with poor overall survival in patients treated with cetuximab. Therefore, our results provide a novel mechanism of FGFR4 in connection with the activation of EGFR and FGFR4 inhibitors and cetuximab combination may be a promising therapeutic option to achieve an optimal response to anti-EGFR therapies in colon cancer.


fibroblast growth factor receptor (FGFRs) are often altered in a variety of human cancer cells and is expressed in hepatocellular carcinoma (HCC). Some literature has proven that cell lines HepG2 and Hep3B and we used PD173074, FGFR4 inhibitor, to explore the role of FGFR4 and the underlying mechanisms in the cell lines.

The results showed that a significant PD173074 HepG2 and Hep3B cells arrested in the G1 phase and inhibited cell proliferation. Furthermore, Western blot analysis revealed that PD173074 decreased levels of P-FRS2α, P-ERK, Cdk2, cyclin E and NF-kB (p65) in the core while increasing the level of ubiquitin and CUL3, an E3 ubiquitin ligase that involves the degradation of cyclin E.

 FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer
FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer

Thermosensitive poloxamer hydrogel heparin-packed bFGF and NGF to treat spinal cord injury

The application of growth factors (GFs) to treat chronic spinal cord injury (SCI) has been shown to promote axonal regeneration and functional recovery. However, the direct administration of the GFS is limited by the rapid degradation and dilution in the injured site. In addition, SCI recovery is a multifactorial process that requires multiple GFS to participate in tissue regeneration.

Based on these facts, controlled delivery of multiple growth factors (GFs) into the lesion area into an attractive strategy to improve SCI. Currently, we develop GFS-based delivery system (called GFS-HP) consisting of basic fibroblast growth factor (bFGF), nerve growth factor (NGF) and heparin-poloxamer (HP) hydrogels through self-assembly mode.

Rat Fibroblast Growth Factor 23 (FGF23) ELISA Kit

DLR-FGF23-Ra-48T 48T
EUR 544.8
Description: A sandwich quantitative ELISA assay kit for detection of Rat Fibroblast Growth Factor 23 (FGF23) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Fibroblast Growth Factor 23 (FGF23) ELISA Kit

DLR-FGF23-Ra-96T 96T
EUR 704.4
Description: A sandwich quantitative ELISA assay kit for detection of Rat Fibroblast Growth Factor 23 (FGF23) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Fibroblast Growth Factor 23 (FGF23) ELISA Kit

RD-FGF23-Hu-48Tests 48 Tests
EUR 501.6

Human Fibroblast Growth Factor 23 (FGF23) ELISA Kit

RD-FGF23-Hu-96Tests 96 Tests
EUR 690

Mouse Fibroblast Growth Factor 23 (FGF23) ELISA Kit

RD-FGF23-Mu-48Tests 48 Tests
EUR 514.8

Mouse Fibroblast Growth Factor 23 (FGF23) ELISA Kit

RD-FGF23-Mu-96Tests 96 Tests
EUR 709.2

Rat Fibroblast Growth Factor 23 (FGF23) ELISA Kit

RD-FGF23-Ra-48Tests 48 Tests
EUR 540

Rat Fibroblast Growth Factor 23 (FGF23) ELISA Kit

RD-FGF23-Ra-96Tests 96 Tests
EUR 746.4

Human Fibroblast Growth Factor 23 (FGF23) ELISA Kit

RDR-FGF23-Hu-48Tests 48 Tests
EUR 523.2

Human Fibroblast Growth Factor 23 (FGF23) ELISA Kit

RDR-FGF23-Hu-96Tests 96 Tests
EUR 721.2

Mouse Fibroblast Growth Factor 23 (FGF23) ELISA Kit

RDR-FGF23-Mu-48Tests 48 Tests
EUR 536.4

Mouse Fibroblast Growth Factor 23 (FGF23) ELISA Kit

RDR-FGF23-Mu-96Tests 96 Tests
EUR 741.6

Rat Fibroblast Growth Factor 23 (FGF23) ELISA Kit

RDR-FGF23-Ra-48Tests 48 Tests
EUR 564

Rat Fibroblast Growth Factor 23 (FGF23) ELISA Kit

RDR-FGF23-Ra-96Tests 96 Tests
EUR 781.2

FGF23(FGF23/638) Antibody

BNCA0638-250 250uL
EUR 459.6
Description: Primary antibody against FGF23(FGF23/638), APC conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCAP0638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCAP0638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC610638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF660R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC610638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF660R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC680638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF568 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC680638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF568 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCR0638-250 250uL
EUR 459.6
Description: Primary antibody against FGF23(FGF23/638), RPE conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNUB0638-100 100uL
EUR 250.8
Description: Primary antibody against FGF23(FGF23/638), Concentration: 0.2mg/mL

FGF23(FGF23/638) Antibody

BNUB0638-500 500uL
EUR 549.6
Description: Primary antibody against FGF23(FGF23/638), Concentration: 0.2mg/mL

FGF23(FGF23/638) Antibody

BNC430638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF543 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC430638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF543 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC400638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF640R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC400638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF640R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC880638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF488A conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC880638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF488A conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC810638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF680R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC810638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF680R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCP0638-250 250uL
EUR 459.6
Description: Primary antibody against FGF23(FGF23/638), PerCP conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNUM0638-50 50uL
EUR 474
Description: Primary antibody against FGF23(FGF23/638), 1mg/mL

FGF23(FGF23/638) Antibody

BNC050638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF405M conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC050638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF405M conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC700638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF770 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC700638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF770 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC800638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF680 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC800638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF680 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCB0638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), Biotin conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCB0638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), Biotin conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC940638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF594 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC940638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF594 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC550638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF555 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC550638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF555 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCH0638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCH0638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC470638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF647 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC470638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF647 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC040638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF405S conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC040638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF405S conjugate, Concentration: 0.1mg/mL

Fgf23/ Rat Fgf23 ELISA Kit

ELI-02562r 96 Tests
EUR 1063.2

FGF23 Antibody

CSB-PA163892-
EUR 402
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

FGF23 Antibody

CSB-PA163892-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

FGF23 Antibody

1-CSB-PA13919A0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200

FGF23 Antibody

1-CSB-PA060188
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/20000

FGF23 Antibody

1-CSB-PA005032
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

Fgf23 Antibody

1-CSB-PA008629LA01RA
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf23. Recognizes Fgf23 from Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

FGF23 Antibody

DF3596 200ul
EUR 420

FGF23 Antibody

AF6542 100ul
EUR 420

FGF23 siRNA

20-abx916823
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FGF23 siRNA

20-abx916824
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FGF23 antibody

70R-32433 100 ug
EUR 392.4
Description: Rabbit polyclonal FGF23 antibody

FGF23 Peptide

45-588P 0.1 mg
EUR 405.6
Description: FGF23 Peptide

Fgf23 Peptide

42-859P 0.1 mg
EUR 405.6
Description: (IN) Fgf23 (mouse) peptide

FGF23 protein

30R-AF040 20 ug
EUR 327.6
Description: Purified recombinant Human FGF23 protein

FGF23 Antibody

34248-100ul 100ul
EUR 302.4

FGF23 Antibody

34248-50ul 50ul
EUR 224.4

FGF23 Antibody

ABD3596 100 ug
EUR 525.6

FGF23 siRNA

20-abx901951
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

anti-FGF23

YF-PA15529 50 ul
EUR 435.6
Description: Mouse polyclonal to FGF23

anti-FGF23

YF-PA15530 50 ug
EUR 435.6
Description: Mouse polyclonal to FGF23

FGF23 Antibody

R32319 100 ug
EUR 419

Fgf23 Antibody

R33890-100UG 100 ug
EUR 399

FGF23 Antibody

R35632-100UG 100 ug
EUR 399

FGF23 Blocking Peptide

DF3596-BP 1mg
EUR 234

FGF23 Conjugated Antibody

C34248 100ul
EUR 476.4

FGF23 cloning plasmid

CSB-CL008629HU-10ug 10ug
EUR 385.2
Description: A cloning plasmid for the FGF23 gene.

FGF23 Rabbit pAb

A14073-100ul 100 ul
EUR 369.6

FGF23 Rabbit pAb

A14073-200ul 200 ul
EUR 550.8

FGF23 Rabbit pAb

A14073-20ul 20 ul
EUR 219.6

FGF23 Rabbit pAb

A14073-50ul 50 ul
EUR 267.6

FGF23 Blocking Peptide

20-abx162431
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

FGF23 Rabbit pAb

A6124-100ul 100 ul
EUR 369.6

FGF23 Rabbit pAb

A6124-200ul 200 ul
EUR 550.8

FGF23 Rabbit pAb

A6124-20ul 20 ul
EUR 219.6

FGF23 Rabbit pAb

A6124-50ul 50 ul
EUR 267.6

Anti-FGF23 Antibody

A00478-3 100ug/vial
EUR 352.8

Anti-FGF23 Antibody

PB9868 100ug/vial
EUR 352.8

Anti-FGF23 antibody

STJ27877 100 µl
EUR 332.4
Description: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).

Anti-FGF23 antibody

STJ71073 100 µg
EUR 430.8

Anti-FGF23 antibody

STJ116008 100 µl
EUR 332.4
Description: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).

Fgf23 Polyclonal Antibody

A55822-020 20 ul Ask for price

Fgf23 Polyclonal Antibody

A55822-050 50 ul Ask for price

Fgf23 Polyclonal Antibody

A55822-100 100 ul
EUR 423.5

Fgf23 Polyclonal Antibody

A55822
  • EUR 684.66
  • Ask for price
  • Ask for price
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

FGF23 Antibody, HRP conjugated

1-CSB-PA13919B0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

FGF23 Antibody, FITC conjugated

1-CSB-PA13919C0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

FGF23 Antibody, Biotin conjugated

1-CSB-PA13919D0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Fgf23 Antibody, HRP conjugated

1-CSB-PA008629LB01RA
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf23. Recognizes Fgf23 from Rat. This antibody is HRP conjugated. Tested in the following application: ELISA

Fgf23 Antibody, FITC conjugated

1-CSB-PA008629LC01RA
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf23. Recognizes Fgf23 from Rat. This antibody is FITC conjugated. Tested in the following application: ELISA

Fgf23 Antibody, Biotin conjugated

1-CSB-PA008629LD01RA
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf23. Recognizes Fgf23 from Rat. This antibody is Biotin conjugated. Tested in the following application: ELISA

Phospho-FGF23 (Ser212) Antibody

AF3542 100ul
EUR 540

Human FGF23 shRNA Plasmid

20-abx955357
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse FGF23 shRNA Plasmid

20-abx975295
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Rat FGF23 shRNA Plasmid

20-abx987589
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human FGF23 ELISA Kit

ELA-E0746h 96 Tests
EUR 988.8

FGF23 ELISA KIT|Human

EF006823 96 Tests
EUR 826.8

Human FGF23 ELISA Kit

STJ150442 1 kit
EUR 494.4
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of FGF23 in human serum, plasma and other biological fluids

Anti-Fgf23 (mouse) antibody

STJ72630 100 µg
EUR 430.8

Recombinant Human FGF23 Protein

RP00366 10 μg
EUR 265.2

Human FGF23 PicoKine ELISA Kit

EK0759 96 wells
EUR 510
Description: For Quantitative Detection of human FGF23 in cell culture supernates, serum and plasma (heparin, EDTA).

Mouse FGF23 PicoKine ELISA Kit

EK1362 96 wells
EUR 510
Description: For quantitative detection of mouse FGF23 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Rat FGF23 PicoKine ELISA Kit

EK1591 96 wells
EUR 510
Description: For quantitative detection of rat FGF23 in cell culture supernates, serum and plasma (heparin, EDTA).

ELISA kit for Mouse FGF23

EK5626 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse FGF23 in samples from serum, plasma, tissue homogenates and other biological fluids.

Polyclonal Goat Anti-FGF23 Antibody

APG00121G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-FGF23 . This antibody is tested and proven to work in the following applications:

FGF23 ELISA Kit (Human) (OKBB00801)

OKBB00801 96 Wells
EUR 606
Description: Description of target: Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. It is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate metabolism. The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by Osteocytes in response to elevated Calcitriol. And it acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption and increases excretion of phosphate. Also, FGF23 may suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

FGF23 ELISA Kit (Mouse) (OKBB00944)

OKBB00944 96 Wells
EUR 606
Description: Description of target: Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. It is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate metabolism. The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by Osteocytes in response to elevated Calcitriol. And it acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption and increases excretion of phosphate. Also, FGF23 may suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

Fgf23 ELISA Kit (Rat) (OKBB01114)

OKBB01114 96 Wells
EUR 606
Description: Description of target: Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. It is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate metabolism. The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by Osteocytes in response to elevated Calcitriol. And it acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption and increases excretion of phosphate. Also, FGF23 may suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption.;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

FGF23 ELISA Kit (Human) (OKAN06265)

OKAN06265 96 Wells
EUR 950.4
Description: Description of target: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.1 pg/mL

FGF23 ELISA Kit (Mouse) (OKAN06421)

OKAN06421 96 Wells
EUR 950.4
Description: Description of target: This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.5 pg/mL

FGF23 ELISA Kit (Human) (OKCD06752)

OKCD06752 96 Wells
EUR 903.6
Description: Description of target: Recombinant Human Fibroblast Growth Factor-23;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 6.5pg/mL

FGF23 ELISA Kit (Mouse) (OKCD06753)

OKCD06753 96 Wells
EUR 934.8
Description: Description of target: This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 6.5pg/mL

FGF23 ELISA Kit (Rat) (OKCD06754)

OKCD06754 96 Wells
EUR 1201.2
Description: Description of target: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: < 5.7pg/mL

FGF23 ELISA Kit (Mouse) (OKEH04074)

OKEH04074 96 Wells
EUR 652.8
Description: Description of target: This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.67 pg/mL

FGF23 ELISA Kit (Human) (OKEH04624)

OKEH04624 96 Wells
EUR 652.8
Description: Description of target: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 10 pg/mL

Fgf23 ORF Vector (Rat) (pORF)

ORF067103 1.0 ug DNA
EUR 607.2

FGF23 ORF Vector (Human) (pORF)

ORF004038 1.0 ug DNA
EUR 114

Fgf23 ORF Vector (Mouse) (pORF)

ORF044825 1.0 ug DNA
EUR 607.2

pECMV-Fgf23-m-FLAG Plasmid

PVT14973 2 ug
EUR 390

Fgf23 Polyclonal Antibody, HRP Conjugated

A55823-050 50 ul
EUR 302.5

Fgf23 Polyclonal Antibody, HRP Conjugated

A55823-100 100 ul
EUR 423.5

Fgf23 Polyclonal Antibody, FITC Conjugated

A55824-050 50 ul
EUR 302.5

Fgf23 Polyclonal Antibody, FITC Conjugated

A55824-100 100 ul
EUR 423.5

Fgf23 Polyclonal Antibody, Biotin Conjugated

A55825-050 50 ul
EUR 302.5

Fgf23 Polyclonal Antibody, Biotin Conjugated

A55825-100 100 ul
EUR 423.5

Fgf23 Polyclonal Antibody, HRP Conjugated

A55823
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Fgf23 Polyclonal Antibody, FITC Conjugated

A55824
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Fgf23 Polyclonal Antibody, Biotin Conjugated

A55825
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Monoclonal FGF23 (Fibroblast Growth Factor 23) Antibody - With BSA and Azide, Clone: FGF23/638

AMM00110G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human FGF23 (Fibroblast Growth Factor 23) - With BSA and Azide. The antibodies are raised in Mouse and are from clone FGF23/638. This antibody is applicable in E

Monoclonal FGF23 (Fibroblast Growth Factor 23) Antibody - Without BSA and Azide, Clone: FGF23/638

AMM00433G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human FGF23 (Fibroblast Growth Factor 23) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone FGF23/638. This antibody is applicable in E

Rat Fibroblast growth factor 23 (Fgf23)

1-CSB-EP008629RA
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Rat Fibroblast growth factor 23(Fgf23) expressed in E.coli

Rat Fibroblast growth factor 23 (Fgf23)

1-CSB-YP008629RA
  • EUR 604.80
  • EUR 318.00
  • EUR 2198.40
  • EUR 915.60
  • EUR 1459.20
  • EUR 400.80
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Rat Fibroblast growth factor 23(Fgf23) expressed in Yeast

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx110407
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx102851
  • EUR 477.60
  • EUR 159.60
  • EUR 1328.40
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx102852
  • EUR 477.60
  • EUR 159.60
  • EUR 1328.40
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx102853
  • EUR 477.60
  • EUR 159.60
  • EUR 1328.40
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx102854
  • EUR 493.20
  • EUR 159.60
  • EUR 1362.00
  • EUR 661.20
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx172404
  • EUR 1011.60
  • EUR 526.80
  • 1 mg
  • 200 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx121603
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx131707
  • EUR 376.80
  • EUR 944.40
  • EUR 493.20
  • EUR 184.80
  • EUR 309.60
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx006316
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx014000
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Fibroblast Growth Factor 23 (FGF23) Antibody

abx331469-100ul 100 ul
EUR 510

Fibroblast Growth Factor 23 (Fgf23) Antibody

abx432059-200ul 200 ul
EUR 460.8

Fibroblast Growth Factor 23 (FGF23) Antibody

abx432686-200ul 200 ul
EUR 460.8

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx301065
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx323549
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx328108
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx176424
  • EUR 1362.00
  • EUR 661.20
  • 1 mg
  • 200 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx176425
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx176426
  • EUR 1479.60
  • EUR 710.40
  • 1 mg
  • 200 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

abx215366-100ug 100 ug
EUR 526.8

Active Fibroblast Growth Factor 23 (FGF23)

4-APA746Mu01
  • EUR 1055.42
  • EUR 405.60
  • EUR 3627.84
  • EUR 1289.28
  • EUR 2458.56
  • EUR 782.40
  • EUR 8889.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 23 expressed in: E.coli

Nori® Human FGF23 ELISA Kit

GR111425 96-well
EUR 553.2

FGF23 sgRNA CRISPR Lentivector set (Human)

K0779301 3 x 1.0 ug
EUR 406.8

Fgf23 sgRNA CRISPR Lentivector set (Mouse)

K4372101 3 x 1.0 ug
EUR 406.8

Fgf23 sgRNA CRISPR Lentivector set (Rat)

K6747701 3 x 1.0 ug
EUR 406.8

Genorise® Recombinant Human FGF23 protein

GR119216 10 µg
EUR 231.6

Recombinant Fibroblast Growth Factor 23 (FGF23)

4-RPA746Hu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 23 expressed in: E.coli

Recombinant Fibroblast Growth Factor 23 (FGF23)

4-RPA746Hu02
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 23 expressed in: E.coli

Recombinant Fibroblast Growth Factor 23 (FGF23)

4-RPA746Hu03
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 23 expressed in: E.coli

Recombinant Fibroblast Growth Factor 23 (FGF23)

4-RPA746Mu01
  • EUR 590.94
  • EUR 282.00
  • EUR 1886.02
  • EUR 708.67
  • EUR 1297.34
  • EUR 470.40
  • EUR 4535.04
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 23 expressed in: E.coli

Fibroblast Growth Factor 23 (FGF23) Antibody (HRP)

20-abx108961
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Fibroblast Growth Factor 23 (FGF23) Protein

20-abx066603
  • EUR 844.80
  • EUR 343.20
  • EUR 2598.00
  • EUR 994.80
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Fibroblast Growth Factor 23 (FGF23) Protein

20-abx066604
  • EUR 844.80
  • EUR 343.20
  • EUR 2598.00
  • EUR 994.80
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Fibroblast Growth Factor 23 (FGF23) Protein

20-abx066605
  • EUR 844.80
  • EUR 343.20
  • EUR 2598.00
  • EUR 994.80
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Fibroblast Growth Factor 23 (FGF23) Protein

20-abx066606
  • EUR 828.00
  • EUR 343.20
  • EUR 2548.80
  • EUR 978.00
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody (Biotin)

20-abx106128
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody (FITC)

20-abx107542
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Rat Fibroblast Growth Factor 23 (FGF23) Protein

20-abx653390
  • EUR 927.60
  • EUR 360.00
  • EUR 2932.80
  • EUR 1111.20
  • EUR 661.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody (HRP)

20-abx316136
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody (FITC)

20-abx316137
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody (Biotin)

20-abx316138
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody (Biotin)

20-abx274345
  • EUR 410.40
  • EUR 243.60
  • EUR 1028.40
  • EUR 526.80
  • EUR 343.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody (Biotin)

20-abx272036
  • EUR 510.00
  • EUR 276.00
  • EUR 1429.20
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fgf23 ELISA Kit (Rat) : 96 Wells (OKEH02744)

OKEH02744 96 Wells
EUR 652.8
Description: Description of target: ;Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 8.02 pg/mL

FGF23 sgRNA CRISPR Lentivector (Human) (Target 1)

K0779302 1.0 ug DNA
EUR 184.8

FGF23 sgRNA CRISPR Lentivector (Human) (Target 2)

K0779303 1.0 ug DNA
EUR 184.8

It GFS-HP is a kind of thermosensitive hydrogel that is suitable for administration in vivo orthotopic. Meanwhile, the 3D porous structure of the hydrogel is commonly used to load large quantities GFs.After GFS-HP single injection into the spinal cord lesion, sustained release of NGF and bFGF from HP can significantly improve the survival of neurons, axons regenerate, oppression astrogliosis reactive and recovery of locomotor, when compared with GFS treatment free or HP.

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