FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer

FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer

Fibroblast growth factor receptor 4 (FGFR4) is known to induce cancer cell proliferation, invasion, and anti-apoptosis through activation of the RAS / RAF / ERK and PI3K / pathways AKT, also known as the molecular basis primary carcinogenesis of colon cancer associated with EGFR signaling. However, the interaction of FGFR4 and EGFR signal with respect to the development of colon cancer is not clear.

Here, we investigated the potential crosstalk between FGFR4 and EGFR, and the effect of anti-EGFR therapy in the treatment of colon cancer. To explore the biological role of FGFR4 in cancer development, RNA-seq is done by using a colon cell line transfected FGFR4. Gene ontology data showed upregulation of genes related to EGFR signaling and we identified that the secret of FGFR4 excess EGFR ligands such as AREG with the activation of EGFR and erbB3 result. These results also demonstrated in vivo study and cooperative interaction of EGFR and FGFR4 promoted tumor growth. In addition, reduced excess FGFR4 cetuximab-induced cytotoxicity and FGFR4 inhibitor combinations (BLU9931) and cetuximab showed profound antitumor effect of cetuximab alone.

Clinically, we found a positive correlation between FGFR4 and AREG expression in tumor tissue but not in normal tissue of the colon cancer patients and these expressions were significantly correlated with poor overall survival in patients treated with cetuximab. Therefore, our results provide a novel mechanism of FGFR4 in connection with the activation of EGFR and FGFR4 inhibitors and cetuximab combination may be a promising therapeutic option to achieve an optimal response to anti-EGFR therapies in colon cancer.


fibroblast growth factor receptor (FGFRs) are often altered in a variety of human cancer cells and is expressed in hepatocellular carcinoma (HCC). Some literature has proven that cell lines HepG2 and Hep3B and we used PD173074, FGFR4 inhibitor, to explore the role of FGFR4 and the underlying mechanisms in the cell lines.

The results showed that a significant PD173074 HepG2 and Hep3B cells arrested in the G1 phase and inhibited cell proliferation. Furthermore, Western blot analysis revealed that PD173074 decreased levels of P-FRS2α, P-ERK, Cdk2, cyclin E and NF-kB (p65) in the core while increasing the level of ubiquitin and CUL3, an E3 ubiquitin ligase that involves the degradation of cyclin E.

 FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer
FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer

Thermosensitive poloxamer hydrogel heparin-packed bFGF and NGF to treat spinal cord injury

The application of growth factors (GFs) to treat chronic spinal cord injury (SCI) has been shown to promote axonal regeneration and functional recovery. However, the direct administration of the GFS is limited by the rapid degradation and dilution in the injured site. In addition, SCI recovery is a multifactorial process that requires multiple GFS to participate in tissue regeneration.

Based on these facts, controlled delivery of multiple growth factors (GFs) into the lesion area into an attractive strategy to improve SCI. Currently, we develop GFS-based delivery system (called GFS-HP) consisting of basic fibroblast growth factor (bFGF), nerve growth factor (NGF) and heparin-poloxamer (HP) hydrogels through self-assembly mode.

FGF23(FGF23/638) Antibody

BNC430638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF543 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC430638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF543 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC050638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF405M conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC050638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF405M conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC550638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF555 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC550638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF555 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC700638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF770 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC700638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF770 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC610638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF660R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC610638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF660R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCP0638-250 250uL
EUR 459.6
Description: Primary antibody against FGF23(FGF23/638), PerCP conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCR0638-250 250uL
EUR 459.6
Description: Primary antibody against FGF23(FGF23/638), RPE conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCA0638-250 250uL
EUR 459.6
Description: Primary antibody against FGF23(FGF23/638), APC conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCAP0638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCAP0638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCH0638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCH0638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638), 0.2mg/mL

BNUB0638-100 100uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), 0.2mg/mL

BNUB0638-500 500uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), 1mg/mL

BNUM0638-50 50uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23

cyt-020 5µg
EUR 60
Description: Recombinant Human Fibroblast Growth Factor-23

FGF23

E8ER1908-82 100ul
EUR 275
Description: Available in various conjugation types.

FGF23

CSB-CL008629HU 10 μg plasmid + 200μl Glycerol Ask for price

Fgf23/ Rat Fgf23 ELISA Kit

ELI-02562r 96 Tests
EUR 1063.2

C28 / FGF23-R2 / FGF23 (212-239 ) (Human)

073-80 100 μg
EUR 347.76

FGF23(FGF23/638), CF594 conjugate, 0.1mg/mL

BNC940638-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), CF594 conjugate, 0.1mg/mL

BNC940638-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), CF647 conjugate, 0.1mg/mL

BNC470638-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), CF647 conjugate, 0.1mg/mL

BNC470638-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), CF568 conjugate, 0.1mg/mL

BNC680638-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), CF568 conjugate, 0.1mg/mL

BNC680638-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), CF405S conjugate, 0.1mg/mL

BNC040638-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), CF405S conjugate, 0.1mg/mL

BNC040638-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), CF488A conjugate, 0.1mg/mL

BNC880638-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), CF488A conjugate, 0.1mg/mL

BNC880638-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), CF640R conjugate, 0.1mg/mL

BNC400638-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), CF640R conjugate, 0.1mg/mL

BNC400638-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), Biotin conjugate, 0.1mg/mL

BNCB0638-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23(FGF23/638), Biotin conjugate, 0.1mg/mL

BNCB0638-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

FGF23, Sf9

cyt-1102 2µg
EUR 60
Description: Recombinant Human Fibroblast Growth Factor-23, Sf9

FGF23, His

cyt-374 2µg
EUR 60
Description: Recombinant Human Fibroblast Growth Factor-23 His Tag

FGF23 siRNA

20-abx916823
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

FGF23 siRNA

20-abx916824
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

FGF23 siRNA

20-abx901951
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

FGF23 protein

30R-AF040 20 ug
EUR 312
Description: Purified recombinant Human FGF23 protein

Fgf23 Peptide

42-859P 0.1 mg
EUR 405.6
Description: (IN) Fgf23 (mouse) peptide

FGF23 Peptide

45-588P 0.1 mg
EUR 405.6
Description: FGF23 Peptide

FGF23 Antibody

8C12369 50ug
EUR 368
Description: FGF23 Antibody

FGF23 Antibody

34248 100ul
EUR 319

FGF23 Antibody

34248-100ul 100ul
EUR 302.4

FGF23 Antibody

34248-50ul 50ul
EUR 224.4

FGF23 Antibody

E034248 100μg/100μl
EUR 255
Description: Available in various conjugation types.

FGF23 Antibody

E11-12369C 100μg
EUR 225
Description: Available in various conjugation types.

FGF23 Antibody

E19-3596 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FGF23 Antibody

DF3596 200ul
EUR 420

FGF23 Antibody

DF3596-100ul 100ul
EUR 280

FGF23 Antibody

DF3596-200ul 200ul
EUR 350

FGF23 Antibody

E38PA3938 100ul
EUR 225
Description: Available in various conjugation types.

FGF23 Antibody

CAC11002-100ug 100ug
EUR 314

FGF23 Antibody

CAC11002-50ug 50ug
EUR 199.2

Fgf23 Antibody

CAC07351-100ug 100ug
EUR 314

Fgf23 Antibody

CAC07351-50ug 50ug
EUR 199.2

FGF23 antibody

70R-32433 100 ug
EUR 294
Description: Rabbit polyclonal FGF23 antibody

FGF23 Antibody

AF6542 100ul
EUR 420

FGF23 Antibody

AF6542-100ul 100ul
EUR 280

FGF23 Antibody

AF6542-200ul 200ul
EUR 350

FGF23 Antibody

1-CSB-PA005032
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

Fgf23 Antibody

1-CSB-PA008629LA01RA
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf23. Recognizes Fgf23 from Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

FGF23 Antibody

ABD3596 100 ug
EUR 525.6

FGF23 Antibody

1-CSB-PA060188
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/20000

FGF23 Antibody

1-CSB-PA13919A0Rb
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200

FGF23 Antibody

CSB-PA163892- each
EUR 402
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

FGF23 Antibody

CSB-PA163892-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

FGF23 Antibody

R35632-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Fibroblast growth factor 23

Fgf23 Antibody

R33890-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Fibroblast growth factor 23

FGF23 Antibody

R32319 100 ug
EUR 356.15
Description: Fibroblast growth factor 23 is a protein that in humans is encoded by the FGF23 gene. This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).

FGF23 (untagged)-Human fibroblast growth factor 23 (FGF23)

SC304789 10 µg Ask for price

FGF23, C-term

cyt-028 2µg
EUR 60
Description: Recombinant Human Fibroblast Growth Factor-23 C-Terminal

FGF23 Rabbit pAb

E2514073 100ul
EUR 225
Description: Available in various conjugation types.

FGF23 Rabbit pAb

E2516124 100ul
EUR 225
Description: Available in various conjugation types.

FGF23 Rabbit pAb

A14073-100ul 100 ul
EUR 369.6

FGF23 Rabbit pAb

A14073-200ul 200 ul
EUR 550.8

FGF23 Rabbit pAb

A14073-20ul 20 ul
EUR 219.6

FGF23 Rabbit pAb

A14073-50ul 50 ul
EUR 267.6

FGF23 Rabbit pAb

A6124-100ul 100 ul
EUR 369.6

FGF23 Rabbit pAb

A6124-200ul 200 ul
EUR 550.8

FGF23 Rabbit pAb

A6124-20ul 20 ul
EUR 219.6

FGF23 Rabbit pAb

A6124-50ul 50 ul
EUR 267.6

FGF23 (GFP-tagged) - Human fibroblast growth factor 23 (FGF23)

RG210127 10 µg Ask for price

Fgf23 (untagged) - Mouse fibroblast growth factor 23 (Fgf23), (10ug)

MC210228 10 µg Ask for price

FGF23 cloning plasmid

CSB-CL008629HU-10ug 10ug
EUR 385.2
Description: A cloning plasmid for the FGF23 gene.

FGF23 Blocking Peptide

20-abx162431
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

FGF23 Blocking Peptide

DF3596-BP 1mg
EUR 234

Recombinant Human FGF23

Z100985 20 µg
EUR 235
Description: FGF-23 is a protein of ∼30 kDa that is proteolytically processed to generate smaller N-terminal (18 kDa) and C-terminal (12 kDa) fragments. The N-terminal fragment of FGF-23 contains the FGF receptor (FGFR)-binding domain. In vivo studies using synthetic peptides have indicated that neither of the processed N-terminal or C-terminal fragments of FGF-23 can influence serum phosphate levels. FGF-23 can decrease the activity of NaPi-2a and NaPi-2c cotransporters to reduce renal phosphate reabsorption and thereby can increase urinary phosphate excretion. Similarly, FGF-23 can suppress the expression of 1-alpha-hydroxylase to reduce the production of the active vitamin D metabolite 1,25(OH)2D. Moreover, FGF-23 can also induce 24- hydroxylase, which degrades 1,25(OH)2D

Recombinant Human FGF23

Z100989 1.0 mg
EUR 5100
Description: FGF-23 is a protein of ∼30 kDa that is proteolytically processed to generate smaller N-terminal (18 kDa) and C-terminal (12 kDa) fragments. The N-terminal fragment of FGF-23 contains the FGF receptor (FGFR)-binding domain. In vivo studies using synthetic peptides have indicated that neither of the processed N-terminal or C-terminal fragments of FGF-23 can influence serum phosphate levels. FGF-23 can decrease the activity of NaPi-2a and NaPi-2c cotransporters to reduce renal phosphate reabsorption and thereby can increase urinary phosphate excretion. Similarly, FGF-23 can suppress the expression of 1-alpha-hydroxylase to reduce the production of the active vitamin D metabolite 1,25(OH)2D. Moreover, FGF-23 can also induce 24- hydroxylase, which degrades 1,25(OH)2D

FGF23 Polyclonal Antibody

E914073 100ul
EUR 225
Description: Available in various conjugation types.

FGF23 Polyclonal Antibody

E96124 100ul
EUR 225
Description: Available in various conjugation types.

FGF23 Conjugated Antibody

C34248 100ul
EUR 476.4

Fgf23 Polyclonal Antibody

A55822
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

FGF 23 (FGF23) mouse monoclonal antibody, clone FGF23/638, Purified

AM50270PU-S 100 µg Ask for price

FGF 23 (FGF23) mouse monoclonal antibody, clone FGF23/638, Purified

AM50270PU-T 20 µg Ask for price

FGF23 (93-141) (Human)

073-64 100 μg
EUR 347.76

FGF23 (144-175 ) (Human)

073-66 100 μg
EUR 347.76

Fgf23 (GFP-tagged) - Mouse fibroblast growth factor 23 (Fgf23), (10ug)

MG227482 10 µg Ask for price

Fgf23 (Myc-DDK-tagged) - Mouse fibroblast growth factor 23 (Fgf23)

MR227482 10 µg Ask for price

FGF23 (Myc-DDK-tagged)-Human fibroblast growth factor 23 (FGF23)

RC210127 10 µg Ask for price

Fgf23 (untagged ORF) - Rat fibroblast growth factor 23 (Fgf23), (10 ug)

RN210949 10 µg Ask for price

FGF23 ELISA KIT|Human

EF006823 96 Tests
EUR 826.8

Human FGF23 ELISA Kit

ELA-E0746h 96 Tests
EUR 988.8

Mouse FGF23 ELISA Kit

EK5626 96 tests
EUR 599

Human FGF23 ELISA Kit

STJ150442 1 kit
EUR 494.4
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of FGF23 in human serum, plasma and other biological fluids

Rat FGF23 shRNA Plasmid

20-abx987589
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Mouse FGF23 shRNA Plasmid

20-abx975295
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Human FGF23 shRNA Plasmid

20-abx955357
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Fgf23 Antibody, HRP conjugated

1-CSB-PA008629LB01RA
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf23. Recognizes Fgf23 from Rat. This antibody is HRP conjugated. Tested in the following application: ELISA

FGF23 Antibody, HRP conjugated

1-CSB-PA13919B0Rb
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

OPPA02583-5UG - FGF23 Protein

OPPA02583-5UG 5ug
EUR 70

Fgf23 Antibody, FITC conjugated

1-CSB-PA008629LC01RA
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf23. Recognizes Fgf23 from Rat. This antibody is FITC conjugated. Tested in the following application: ELISA

FGF23 Antibody, FITC conjugated

1-CSB-PA13919C0Rb
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OACD03513-1ML - FGF23 Antibody

OACD03513-1ML 1ml
EUR 609

OACD03514-1ML - FGF23 Antibody

OACD03514-1ML 1ml
EUR 609

OACD03515-1ML - FGF23 Antibody

OACD03515-1ML 1ml
EUR 609

OACD03516-1ML - FGF23 Antibody

OACD03516-1ML 1ml
EUR 619

OACD00246-1ML - FGF23 Antibody

OACD00246-1ML 1ml
EUR 649

OAAN03551-50UL - FGF23 Antibody

OAAN03551-50UL 50ul
EUR 149

OACA10462-50UG - FGF23 Antibody

OACA10462-50UG 50ug
EUR 179

Recombinant Human FGF23 Protein

RP00366 10 μg
EUR 265.2

Fgf23 Antibody, Biotin conjugated

1-CSB-PA008629LD01RA
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf23. Recognizes Fgf23 from Rat. This antibody is Biotin conjugated. Tested in the following application: ELISA

FGF23 Antibody, Biotin conjugated

1-CSB-PA13919D0Rb
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OAEB01623-100UG - FGF23 Antibody

OAEB01623-100UG 100ug
EUR 349

OACD03513-100UL - FGF23 Antibody

OACD03513-100UL 100ul
EUR 179

OACD03514-100UL - FGF23 Antibody

OACD03514-100UL 100ul
EUR 179

OACD03515-100UL - FGF23 Antibody

OACD03515-100UL 100ul
EUR 179

OACD03516-100UL - FGF23 Antibody

OACD03516-100UL 100ul
EUR 179

OACD00246-100UL - FGF23 Antibody

OACD00246-100UL 100ul
EUR 189

OACD00246-200UL - FGF23 Antibody

OACD00246-200UL 200ul
EUR 269

OAAF02974-100UG - FGF23 Antibody

OAAF02974-100UG 100ug
EUR 329

OAAN03551-100UL - FGF23 Antibody

OAAN03551-100UL 100ul
EUR 249

OAAN03551-200UL - FGF23 Antibody

OAAN03551-200UL 200ul
EUR 389

OACA10462-100UG - FGF23 Antibody

OACA10462-100UG 100ug
EUR 319

Fgf23 (Myc-DDK-tagged ORF) - Rat fibroblast growth factor 23 (Fgf23), (10 ug)

RR210949 10 µg Ask for price

Fgf23 ORF Vector (Rat) (pORF)

ORF067103 1.0 ug DNA
EUR 607.2

Fgf23 ORF Vector (Mouse) (pORF)

ORF044825 1.0 ug DNA
EUR 607.2

FGF23 ORF Vector (Human) (pORF)

ORF004038 1.0 ug DNA
EUR 114

Lenti ORF clone of Fgf23 (mGFP-tagged) - Mouse fibroblast growth factor 23 (Fgf23)

MR227482L4 10 µg Ask for price

Rat FGF23 PicoKine ELISA Kit

EK1591 96 wells
EUR 510
Description: For quantitative detection of rat FGF23 in cell culture supernates, serum and plasma (heparin, EDTA).

FGF23 ELISA Kit (Rat) (OKCD06754)

OKCD06754 96 Wells
EUR 1201.2
Description: Description of target: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: < 5.7pg/mL

Fgf23 ELISA Kit (Rat) (OKBB01114)

OKBB01114 96 Wells
EUR 606
Description: Description of target: Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. It is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate metabolism. The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by Osteocytes in response to elevated Calcitriol. And it acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption and increases excretion of phosphate. Also, FGF23 may suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption.;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

Human FGF23 knockout cell line

ABC-KH5519 1 vial Ask for price
Description: Human FGF23 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Mouse FGF23 PicoKine ELISA Kit

EK1362 96 wells
EUR 510
Description: For quantitative detection of mouse FGF23 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human FGF23 PicoKine ELISA Kit

EK0759 96 wells
EUR 510
Description: For Quantitative Detection of human FGF23 in cell culture supernates, serum and plasma (heparin, EDTA).

Human FGF23 knockdown cell line

ABC-KD5519 1 vial Ask for price
Description: Human FGF23 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human FGF23 Protein Lysate 20ug

IHUFGF23PLLY20UG each
EUR 213
Description: Human FGF23 Protein Lysate 20ug

FGF23 ELISA Kit (Human) (OKCD06752)

OKCD06752 96 Wells
EUR 903.6
Description: Description of target: Recombinant Human Fibroblast Growth Factor-23;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 6.5pg/mL

FGF23 ELISA Kit (Mouse) (OKCD06753)

OKCD06753 96 Wells
EUR 934.8
Description: Description of target: This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 6.5pg/mL

FGF23 ELISA Kit (Human) (OKAN06265)

OKAN06265 96 Wells
EUR 950.4
Description: Description of target: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.1 pg/mL

FGF23 ELISA Kit (Mouse) (OKAN06421)

OKAN06421 96 Wells
EUR 950.4
Description: Description of target: This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.5 pg/mL

FGF23 ELISA Kit (Human) (OKBB00801)

OKBB00801 96 Wells
EUR 606
Description: Description of target: Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. It is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate metabolism. The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by Osteocytes in response to elevated Calcitriol. And it acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption and increases excretion of phosphate. Also, FGF23 may suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

FGF23 ELISA Kit (Mouse) (OKBB00944)

OKBB00944 96 Wells
EUR 606
Description: Description of target: Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. It is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate metabolism. The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by Osteocytes in response to elevated Calcitriol. And it acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption and increases excretion of phosphate. Also, FGF23 may suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

FGF23 ELISA Kit (Human) (OKEH04624)

OKEH04624 96 Wells
EUR 652.8
Description: Description of target: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 10 pg/mL

FGF23 ELISA Kit (Mouse) (OKEH04074)

OKEH04074 96 Wells
EUR 652.8
Description: Description of target: This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.67 pg/mL

Rat Phosphatonin (FGF23) ELISA Kit

IRTFGF23KT each
EUR 702
Description: Rat Phosphatonin (FGF23) ELISA Kit

cFGF / FGF23 (180-251) (Human) - MagBead

MB-073-62 1 ml
EUR 842.4

Human Phosphatonin (FGF23) ELISA Kit

IHUFGF23KT each
EUR 702
Description: Human Phosphatonin (FGF23) ELISA Kit

Mouse Phosphatonin (FGF23) ELISA Kit

IMSFGF23KT each
EUR 665
Description: Mouse Phosphatonin (FGF23) ELISA Kit

Monoclonal FGF23 (Fibroblast Growth Factor 23) Antibody - With BSA and Azide, Clone: FGF23/638

AMM00110G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human FGF23 (Fibroblast Growth Factor 23) - With BSA and Azide. The antibodies are raised in Mouse and are from clone FGF23/638. This antibody is applicable in E

OCOA09104-20UG - FGF23 Protein Lysate

OCOA09104-20UG 20ug
EUR 169

Monoclonal FGF23 (Fibroblast Growth Factor 23) Antibody - Without BSA and Azide, Clone: FGF23/638

AMM00433G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human FGF23 (Fibroblast Growth Factor 23) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone FGF23/638. This antibody is applicable in E

FGF23 Over-expression Lysate Product

GWB-BC26C7 0.1 mg Ask for price

Goat Polyclonal Antibody against FGF23

TA303182 100 µg Ask for price

Fgf23 Polyclonal Antibody, HRP Conjugated

A55823
  • Ask for price
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  • Ask for price
  • 100 µg
  • 50 ul
  • 100 ul

Lenti ORF clone of Fgf23 (Myc-DDK-tagged) - Mouse fibroblast growth factor 23 (Fgf23)

MR227482L3 10 µg Ask for price

Fgf23 Polyclonal Antibody, FITC Conjugated

A55824
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  • Ask for price
  • Ask for price
  • 100 µg
  • 50 ul
  • 100 ul

OPCA01601-1MG - Fgf23 Recombinant Protein

OPCA01601-1MG 1mg
EUR 1977

OPCA01601-20UG - Fgf23 Recombinant Protein

OPCA01601-20UG 20ug
EUR 315

OPCA02659-20UG - Fgf23 Recombinant Protein

OPCA02659-20UG 20ug
EUR 315

OPCD03201-10UG - FGF23 Recombinant Protein

OPCD03201-10UG 10ug
EUR 139

OPCD03201-50UG - FGF23 Recombinant Protein

OPCD03201-50UG 50ug
EUR 349

OPCD03202-10UG - FGF23 Recombinant Protein

OPCD03202-10UG 10ug
EUR 139

OPCD03202-50UG - FGF23 Recombinant Protein

OPCD03202-50UG 50ug
EUR 349

OPCD03203-10UG - FGF23 Recombinant Protein

OPCD03203-10UG 10ug
EUR 139

OPCD03203-50UG - FGF23 Recombinant Protein

OPCD03203-50UG 50ug
EUR 349

OPCD03204-10UG - FGF23 Recombinant Protein

OPCD03204-10UG 10ug
EUR 139

OPCD03204-50UG - FGF23 Recombinant Protein

OPCD03204-50UG 50ug
EUR 339

Fgf23 Polyclonal Antibody, Biotin Conjugated

A55825
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  • Ask for price
  • Ask for price
  • 100 µg
  • 50 ul
  • 100 ul

OPCA01601-100UG - Fgf23 Recombinant Protein

OPCA01601-100UG 100ug
EUR 462

OPCA02659-100UG - Fgf23 Recombinant Protein

OPCA02659-100UG 100ug
EUR 462

OPCA02659-500UG - Fgf23 Recombinant Protein

OPCA02659-500UG 500ug
EUR 1276

OPCD03201-200UG - FGF23 Recombinant Protein

OPCD03201-200UG 200ug
EUR 699

OPCD03202-200UG - FGF23 Recombinant Protein

OPCD03202-200UG 200ug
EUR 699

It GFS-HP is a kind of thermosensitive hydrogel that is suitable for administration in vivo orthotopic. Meanwhile, the 3D porous structure of the hydrogel is commonly used to load large quantities GFs.After GFS-HP single injection into the spinal cord lesion, sustained release of NGF and bFGF from HP can significantly improve the survival of neurons, axons regenerate, oppression astrogliosis reactive and recovery of locomotor, when compared with GFS treatment free or HP.

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