FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer

FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer

Fibroblast growth factor receptor 4 (FGFR4) is known to induce cancer cell proliferation, invasion, and anti-apoptosis through activation of the RAS / RAF / ERK and PI3K / pathways AKT, also known as the molecular basis primary carcinogenesis of colon cancer associated with EGFR signaling. However, the interaction of FGFR4 and EGFR signal with respect to the development of colon cancer is not clear.

Here, we investigated the potential crosstalk between FGFR4 and EGFR, and the effect of anti-EGFR therapy in the treatment of colon cancer. To explore the biological role of FGFR4 in cancer development, RNA-seq is done by using a colon cell line transfected FGFR4. Gene ontology data showed upregulation of genes related to EGFR signaling and we identified that the secret of FGFR4 excess EGFR ligands such as AREG with the activation of EGFR and erbB3 result. These results also demonstrated in vivo study and cooperative interaction of EGFR and FGFR4 promoted tumor growth. In addition, reduced excess FGFR4 cetuximab-induced cytotoxicity and FGFR4 inhibitor combinations (BLU9931) and cetuximab showed profound antitumor effect of cetuximab alone.

Clinically, we found a positive correlation between FGFR4 and AREG expression in tumor tissue but not in normal tissue of the colon cancer patients and these expressions were significantly correlated with poor overall survival in patients treated with cetuximab. Therefore, our results provide a novel mechanism of FGFR4 in connection with the activation of EGFR and FGFR4 inhibitors and cetuximab combination may be a promising therapeutic option to achieve an optimal response to anti-EGFR therapies in colon cancer.


fibroblast growth factor receptor (FGFRs) are often altered in a variety of human cancer cells and is expressed in hepatocellular carcinoma (HCC). Some literature has proven that cell lines HepG2 and Hep3B and we used PD173074, FGFR4 inhibitor, to explore the role of FGFR4 and the underlying mechanisms in the cell lines.

The results showed that a significant PD173074 HepG2 and Hep3B cells arrested in the G1 phase and inhibited cell proliferation. Furthermore, Western blot analysis revealed that PD173074 decreased levels of P-FRS2α, P-ERK, Cdk2, cyclin E and NF-kB (p65) in the core while increasing the level of ubiquitin and CUL3, an E3 ubiquitin ligase that involves the degradation of cyclin E.

 FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer
FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer

Thermosensitive poloxamer hydrogel heparin-packed bFGF and NGF to treat spinal cord injury

The application of growth factors (GFs) to treat chronic spinal cord injury (SCI) has been shown to promote axonal regeneration and functional recovery. However, the direct administration of the GFS is limited by the rapid degradation and dilution in the injured site. In addition, SCI recovery is a multifactorial process that requires multiple GFS to participate in tissue regeneration.

Based on these facts, controlled delivery of multiple growth factors (GFs) into the lesion area into an attractive strategy to improve SCI. Currently, we develop GFS-based delivery system (called GFS-HP) consisting of basic fibroblast growth factor (bFGF), nerve growth factor (NGF) and heparin-poloxamer (HP) hydrogels through self-assembly mode.

FGF23(FGF23/638) Antibody

BNC810638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF680R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC940638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF594 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC940638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF594 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC700638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF770 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC700638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF770 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC880638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF488A conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC880638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF488A conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC040638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF405S conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC040638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF405S conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC400638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF640R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC400638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF640R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC050638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF405M conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC050638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF405M conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCB0638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), Biotin conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCB0638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), Biotin conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCAP0638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCAP0638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCR0638-250 250uL
EUR 459.6
Description: Primary antibody against FGF23(FGF23/638), RPE conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCP0638-250 250uL
EUR 459.6
Description: Primary antibody against FGF23(FGF23/638), PerCP conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNUM0638-50 50uL
EUR 474
Description: Primary antibody against FGF23(FGF23/638), 1mg/mL

FGF23(FGF23/638) Antibody

BNCH0638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNCH0638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNUB0638-100 100uL
EUR 250.8
Description: Primary antibody against FGF23(FGF23/638), Concentration: 0.2mg/mL

FGF23(FGF23/638) Antibody

BNUB0638-500 500uL
EUR 549.6
Description: Primary antibody against FGF23(FGF23/638), Concentration: 0.2mg/mL

FGF23(FGF23/638) Antibody

BNC550638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF555 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC550638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF555 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC610638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF660R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC610638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF660R conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC680638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF568 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC680638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF568 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC470638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF647 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC470638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF647 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC430638-100 100uL
EUR 238.8
Description: Primary antibody against FGF23(FGF23/638), CF543 conjugate, Concentration: 0.1mg/mL

FGF23(FGF23/638) Antibody

BNC430638-500 500uL
EUR 652.8
Description: Primary antibody against FGF23(FGF23/638), CF543 conjugate, Concentration: 0.1mg/mL

FGF23

E8ER1908-82 100ul
EUR 275
Description: Available in various conjugation types.

FGF23

cyt-020 5µg
EUR 60
Description: Recombinant Human Fibroblast Growth Factor-23

Fgf23/ Rat Fgf23 ELISA Kit

ELI-02562r 96 Tests
EUR 1063.2

FGF23, Sf9

cyt-1102 2µg
EUR 60
Description: Recombinant Human Fibroblast Growth Factor-23, Sf9

FGF23, His

cyt-374 2µg
EUR 60
Description: Recombinant Human Fibroblast Growth Factor-23 His Tag

FGF23 siRNA

20-abx916823
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FGF23 siRNA

20-abx916824
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FGF23 siRNA

20-abx901951
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FGF23 protein

30R-AF040 20 ug
EUR 327.6
Description: Purified recombinant Human FGF23 protein

Fgf23 Peptide

42-859P 0.1 mg
EUR 405.6
Description: (IN) Fgf23 (mouse) peptide

FGF23 Peptide

45-588P 0.1 mg
EUR 405.6
Description: FGF23 Peptide

FGF23 antibody

70R-32433 100 ug
EUR 392.4
Description: Rabbit polyclonal FGF23 antibody

FGF23 Antibody

34248-100ul 100ul
EUR 302.4

FGF23 Antibody

34248-50ul 50ul
EUR 224.4

FGF23 Antibody

ABD3596 100 ug
EUR 525.6

FGF23 Antibody

1-CSB-PA13919A0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200

FGF23 Antibody

CSB-PA163892- each
EUR 402
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

FGF23 Antibody

CSB-PA163892-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

FGF23 Antibody

1-CSB-PA060188
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/20000

FGF23 Antibody

1-CSB-PA005032
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

Fgf23 Antibody

1-CSB-PA008629LA01RA
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf23. Recognizes Fgf23 from Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

FGF23 Antibody

R35632-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Fibroblast growth factor 23

FGF23 Antibody

R32319 100 ug
EUR 356.15
Description: Fibroblast growth factor 23 is a protein that in humans is encoded by the FGF23 gene. This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).

Fgf23 Antibody

R33890-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Fibroblast growth factor 23

FGF23 Antibody

E38PA3938 100ul
EUR 225
Description: Available in various conjugation types.

FGF23 Antibody

AF6542-100ul 100ul
EUR 280

FGF23 Antibody

AF6542-200ul 200ul
EUR 350

FGF23 Antibody

DF3596-100ul 100ul
EUR 280

FGF23 Antibody

DF3596-200ul 200ul
EUR 350

FGF23 Antibody

AF6542 100ul
EUR 280
Description: Human,Mouse,Rat

FGF23 Antibody

DF3596 100ul
EUR 280
Description: Human,Mouse,Rat

FGF23 Antibody

E034248 100μg/100μl
EUR 255
Description: Available in various conjugation types.

FGF23 Antibody

E11-12369C 100μg
EUR 225
Description: Available in various conjugation types.

FGF23 Antibody

E19-3596 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FGF23 Antibody

CAC11002-100ug 100ug
EUR 314

FGF23 Antibody

CAC11002-50ug 50ug
EUR 199.2

Fgf23 Antibody

CAC07351-100ug 100ug
EUR 314

Fgf23 Antibody

CAC07351-50ug 50ug
EUR 199.2

FGF23, C-term

cyt-028 2µg
EUR 60
Description: Recombinant Human Fibroblast Growth Factor-23 C-Terminal

FGF23 Rabbit pAb

A14073-100ul 100 ul
EUR 369.6

FGF23 Rabbit pAb

A14073-200ul 200 ul
EUR 550.8

FGF23 Rabbit pAb

A14073-20ul 20 ul
EUR 219.6

FGF23 Rabbit pAb

A14073-50ul 50 ul
EUR 267.6

FGF23 Rabbit pAb

A6124-100ul 100 ul
EUR 369.6

FGF23 Rabbit pAb

A6124-200ul 200 ul
EUR 550.8

FGF23 Rabbit pAb

A6124-20ul 20 ul
EUR 219.6

FGF23 Rabbit pAb

A6124-50ul 50 ul
EUR 267.6

FGF23 Rabbit pAb

E2516124 100ul
EUR 225
Description: Available in various conjugation types.

FGF23 Rabbit pAb

E2514073 100ul
EUR 225
Description: Available in various conjugation types.

FGF23 cloning plasmid

CSB-CL008629HU-10ug 10ug
EUR 385.2
Description: A cloning plasmid for the FGF23 gene.

FGF23 Blocking Peptide

DF3596-BP 1mg
EUR 234

FGF23 Blocking Peptide

20-abx162431
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

FGF23 Conjugated Antibody

C34248 100ul
EUR 476.4

Fgf23 Polyclonal Antibody

A55822
  • EUR 684.66
  • Ask for price
  • Ask for price
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

FGF23 Polyclonal Antibody

E914073 100ul
EUR 225
Description: Available in various conjugation types.

FGF23 Polyclonal Antibody

E96124 100ul
EUR 225
Description: Available in various conjugation types.

Human FGF23 ELISA Kit

ELA-E0746h 96 Tests
EUR 988.8

FGF23 ELISA KIT|Human

EF006823 96 Tests
EUR 826.8

Human FGF23 ELISA Kit

STJ150442 1 kit
EUR 494.4
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of FGF23 in human serum, plasma and other biological fluids

Rat FGF23 shRNA Plasmid

20-abx987589
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human FGF23 shRNA Plasmid

20-abx955357
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse FGF23 shRNA Plasmid

20-abx975295
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

FGF23 Antibody, HRP conjugated

1-CSB-PA13919B0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Fgf23 Antibody, HRP conjugated

1-CSB-PA008629LB01RA
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf23. Recognizes Fgf23 from Rat. This antibody is HRP conjugated. Tested in the following application: ELISA

FGF23 Antibody, FITC conjugated

1-CSB-PA13919C0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

Fgf23 Antibody, FITC conjugated

1-CSB-PA008629LC01RA
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf23. Recognizes Fgf23 from Rat. This antibody is FITC conjugated. Tested in the following application: ELISA

Recombinant Human FGF23 Protein

RP00366 10 μg
EUR 265.2

FGF23 Antibody, Biotin conjugated

1-CSB-PA13919D0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF23. Recognizes FGF23 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Fgf23 Antibody, Biotin conjugated

1-CSB-PA008629LD01RA
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf23. Recognizes Fgf23 from Rat. This antibody is Biotin conjugated. Tested in the following application: ELISA

Fgf23 ORF Vector (Rat) (pORF)

ORF067103 1.0 ug DNA
EUR 607.2

ELISA kit for Mouse FGF23

EK5626 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse FGF23 in samples from serum, plasma, tissue homogenates and other biological fluids.

FGF23 ORF Vector (Human) (pORF)

ORF004038 1.0 ug DNA
EUR 114

Fgf23 ORF Vector (Mouse) (pORF)

ORF044825 1.0 ug DNA
EUR 607.2

Rat FGF23 PicoKine ELISA Kit

EK1591 96 wells
EUR 510
Description: For quantitative detection of rat FGF23 in cell culture supernates, serum and plasma (heparin, EDTA).

Fgf23 ELISA Kit (Rat) (OKBB01114)

OKBB01114 96 Wells
EUR 606
Description: Description of target: Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. It is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate metabolism. The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by Osteocytes in response to elevated Calcitriol. And it acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption and increases excretion of phosphate. Also, FGF23 may suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption.;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

FGF23 ELISA Kit (Rat) (OKCD06754)

OKCD06754 96 Wells
EUR 1201.2
Description: Description of target: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: < 5.7pg/mL

Mouse FGF23 PicoKine ELISA Kit

EK1362 96 wells
EUR 510
Description: For quantitative detection of mouse FGF23 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human FGF23 PicoKine ELISA Kit

EK0759 96 wells
EUR 510
Description: For Quantitative Detection of human FGF23 in cell culture supernates, serum and plasma (heparin, EDTA).

FGF23 ELISA Kit (Human) (OKAN06265)

OKAN06265 96 Wells
EUR 950.4
Description: Description of target: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.1 pg/mL

FGF23 ELISA Kit (Mouse) (OKAN06421)

OKAN06421 96 Wells
EUR 950.4
Description: Description of target: This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.5 pg/mL

FGF23 ELISA Kit (Human) (OKBB00801)

OKBB00801 96 Wells
EUR 606
Description: Description of target: Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. It is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate metabolism. The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by Osteocytes in response to elevated Calcitriol. And it acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption and increases excretion of phosphate. Also, FGF23 may suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

FGF23 ELISA Kit (Mouse) (OKBB00944)

OKBB00944 96 Wells
EUR 606
Description: Description of target: Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. It is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate metabolism. The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by Osteocytes in response to elevated Calcitriol. And it acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption and increases excretion of phosphate. Also, FGF23 may suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

FGF23 ELISA Kit (Human) (OKCD06752)

OKCD06752 96 Wells
EUR 903.6
Description: Description of target: Recombinant Human Fibroblast Growth Factor-23;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 6.5pg/mL

FGF23 ELISA Kit (Mouse) (OKCD06753)

OKCD06753 96 Wells
EUR 934.8
Description: Description of target: This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 6.5pg/mL

FGF23 ELISA Kit (Human) (OKEH04624)

OKEH04624 96 Wells
EUR 652.8
Description: Description of target: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 10 pg/mL

FGF23 ELISA Kit (Mouse) (OKEH04074)

OKEH04074 96 Wells
EUR 652.8
Description: Description of target: This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.67 pg/mL

Human FGF23 Protein Lysate 20ug

IHUFGF23PLLY20UG each
EUR 213
Description: Human FGF23 Protein Lysate 20ug

Rat Phosphatonin (FGF23) ELISA Kit

IRTFGF23KT each
EUR 702
Description: Rat Phosphatonin (FGF23) ELISA Kit

Mouse Phosphatonin (FGF23) ELISA Kit

IMSFGF23KT each
EUR 665
Description: Mouse Phosphatonin (FGF23) ELISA Kit

Human Phosphatonin (FGF23) ELISA Kit

IHUFGF23KT each
EUR 702
Description: Human Phosphatonin (FGF23) ELISA Kit

Monoclonal FGF23 (Fibroblast Growth Factor 23) Antibody - With BSA and Azide, Clone: FGF23/638

AMM00110G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human FGF23 (Fibroblast Growth Factor 23) - With BSA and Azide. The antibodies are raised in Mouse and are from clone FGF23/638. This antibody is applicable in E

Fgf23 Polyclonal Antibody, HRP Conjugated

A55823
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Monoclonal FGF23 (Fibroblast Growth Factor 23) Antibody - Without BSA and Azide, Clone: FGF23/638

AMM00433G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human FGF23 (Fibroblast Growth Factor 23) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone FGF23/638. This antibody is applicable in E

Fgf23 Polyclonal Antibody, FITC Conjugated

A55824
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Fgf23 Polyclonal Antibody, Biotin Conjugated

A55825
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Nori® Human FGF23 ELISA Kit

GR111425 96-well
EUR 461

Rat Fibroblast growth factor 23 (Fgf23)

1-CSB-YP008629RA
  • EUR 604.80
  • EUR 318.00
  • EUR 2198.40
  • EUR 915.60
  • EUR 1459.20
  • EUR 400.80
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Rat Fibroblast growth factor 23(Fgf23) expressed in Yeast

Rat Fibroblast growth factor 23 (Fgf23)

1-CSB-EP008629RA
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Rat Fibroblast growth factor 23(Fgf23) expressed in E.coli

Fgf23 sgRNA CRISPR Lentivector set (Rat)

K6747701 3 x 1.0 ug
EUR 406.8

Active Fibroblast Growth Factor 23 (FGF23)

4-APA746Mu01
  • EUR 1055.42
  • EUR 405.60
  • EUR 3627.84
  • EUR 1289.28
  • EUR 2458.56
  • EUR 782.40
  • EUR 8889.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 23 expressed in: E.coli

FGF23 sgRNA CRISPR Lentivector set (Human)

K0779301 3 x 1.0 ug
EUR 406.8

Fgf23 sgRNA CRISPR Lentivector set (Mouse)

K4372101 3 x 1.0 ug
EUR 406.8

Active Fibroblast Growth Factor 23 (FGF23)

RPU54905-100ug 100ug
EUR 576.4

Active Fibroblast Growth Factor 23 (FGF23)

RPU54905-1mg 1mg
EUR 2919.8

Active Fibroblast Growth Factor 23 (FGF23)

RPU54905-50ug 50ug
EUR 449.3

Active Fibroblast Growth Factor 23 (FGF23)

RPU59098-100ug 100ug
EUR 1009.8

Active Fibroblast Growth Factor 23 (FGF23)

RPU59098-1mg 1mg
EUR 3948.8

Active Fibroblast Growth Factor 23 (FGF23)

RPU59098-50ug 50ug
EUR 631.1

Active Fibroblast Growth Factor 23 (FGF23)

RPU58721-100ug 100ug
EUR 629.2

Active Fibroblast Growth Factor 23 (FGF23)

RPU58721-1mg 1mg
EUR 2920.3

Active Fibroblast Growth Factor 23 (FGF23)

RPU58721-50ug 50ug
EUR 489.1

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx110407
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx102851
  • EUR 477.60
  • EUR 159.60
  • EUR 1328.40
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx102852
  • EUR 477.60
  • EUR 159.60
  • EUR 1328.40
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx102853
  • EUR 477.60
  • EUR 159.60
  • EUR 1328.40
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx102854
  • EUR 493.20
  • EUR 159.60
  • EUR 1362.00
  • EUR 661.20
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx176424
  • EUR 1362.00
  • EUR 661.20
  • 1 mg
  • 200 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx176425
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx176426
  • EUR 1479.60
  • EUR 710.40
  • 1 mg
  • 200 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx172404
  • EUR 1011.60
  • EUR 526.80
  • 1 mg
  • 200 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

abx215366-100ug 100 ug
EUR 526.8

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx121603
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Fibroblast Growth Factor 23 (FGF23) Antibody

abx331469-100ul 100 ul
EUR 510

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx014000
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx131707
  • EUR 376.80
  • EUR 944.40
  • EUR 493.20
  • EUR 184.80
  • EUR 309.60
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx323549
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx328108
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Fibroblast Growth Factor 23 (Fgf23) Antibody

abx432059-200ul 200 ul
EUR 460.8

Fibroblast Growth Factor 23 (FGF23) Antibody

abx432686-200ul 200 ul
EUR 460.8

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx006316
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Fibroblast Growth Factor 23 (FGF23) Antibody

20-abx301065
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Genorise® Recombinant Human FGF23 protein

GR119216 10 µg
EUR 193

Recombinant Fibroblast Growth Factor 23 (FGF23)

4-RPA746Hu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 23 expressed in: E.coli

Recombinant Fibroblast Growth Factor 23 (FGF23)

4-RPA746Hu02
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 23 expressed in: E.coli

Recombinant Fibroblast Growth Factor 23 (FGF23)

4-RPA746Hu03
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 23 expressed in: E.coli

Recombinant Fibroblast Growth Factor 23 (FGF23)

4-RPA746Mu01
  • EUR 590.94
  • EUR 282.00
  • EUR 1886.02
  • EUR 708.67
  • EUR 1297.34
  • EUR 470.40
  • EUR 4535.04
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 23 expressed in: E.coli

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU41443-100ug 100ug
EUR 554.4

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU41443-1mg 1mg
EUR 2457

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU41443-50ug 50ug
EUR 445.5

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU41444-100ug 100ug
EUR 554.4

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU41444-1mg 1mg
EUR 2457

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU41444-50ug 50ug
EUR 445.5

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU41445-100ug 100ug
EUR 554.4

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU41445-1mg 1mg
EUR 2457

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU41445-50ug 50ug
EUR 445.5

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU41446-100ug 100ug
EUR 540.1

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU41446-1mg 1mg
EUR 2392

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU41446-50ug 50ug
EUR 433.4

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU57854-100ug 100ug
EUR 508.2

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU57854-1mg 1mg
EUR 2358.7

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU57854-50ug 50ug
EUR 415.8

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU56812-100ug 100ug
EUR 470.4

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU56812-1mg 1mg
EUR 2184

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU56812-50ug 50ug
EUR 385

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU58855-100ug 100ug
EUR 685.5

Recombinant Fibroblast Growth Factor 23 (FGF23)

RPU58855-1mg 1mg
EUR 3182.4

It GFS-HP is a kind of thermosensitive hydrogel that is suitable for administration in vivo orthotopic. Meanwhile, the 3D porous structure of the hydrogel is commonly used to load large quantities GFs.After GFS-HP single injection into the spinal cord lesion, sustained release of NGF and bFGF from HP can significantly improve the survival of neurons, axons regenerate, oppression astrogliosis reactive and recovery of locomotor, when compared with GFS treatment free or HP.

Leave A Comment