Fibroblast growth factor 10 is a negative regulator of postnatal neurogenesis in the mouse hypothalamus

Fibroblast growth factor 10 is a negative regulator of postnatal neurogenesis in the mouse hypothalamus

The new neurons are generated in the rodent postnatal hypothalamus, with a subset of soyycytes in the third ventricular wall (3V) serving neural / progenitor stem cells. However, precise stem cell niche organization, intermediate steps and endogenous regulators of postnatal hypothalamic neurogenic remain elusive. The quantitative tracing of the in vivo line revealed that the conditional removal of the fibroblast growth factor 10 (FGF10) from β-Tannytytes expressing FGF10 at the postnatal days (P) 4-5 causes the cell generation significantly from Significant manner by P28, mainly composed of ventraging and doormous neurons and glial cells that persist in adulthood. Further examination in Vivo and ex vivo revealed that the 3V wall is not static and is converted for cellular movements.

In addition, normally β-taperyclets give rise to parenchymatic cells via an intermediate population of α-tenelytes with transient amplification cell characteristics. The loss of FGF10 temporarily attenuates the amplification of β-tanerytes but also seems to delay the output of their α-TaNycyte descendants of the 2V germinal wall. Our results suggest that cell transitances via the α-Tayycyte domain is an essential feature and FGF10 is a negative regulator of the postnatal hypothalamic neurogenic. The variants of FGF8 and FGF10 in unsuccessful Chinese Han patients with CHDS (N = 585) and healthy controls (n = 319) were studied. The expression and function of these variants identified by the patient have been detected to confirm the potential pathogenicity of non-synonymous variants.

The expression of FGF8 and FGF10 when differentiation of human embryonic stem cells (HESCS) with cardiomyocytes and in the Carnegie Stage 13 Human embryo has also been identified. ACS / BFGF resulted in perforation closure rates higher than a step prior to spontaneous, ACS and BFGF healing. Based on histology, optical coherence tomography and electronic transmission microscopy, a trilaminar structure and a uniform thickness with mature and densely packaged collagen fibers were observed in the ACS / BFGF group. The evaluation of the hearing interventions of the brainstem has also shown that the ACS / BFGF treatment has favored faster functional hearing recovery from the control group.

Exploring a peptidomimic approach of N-Cadherin in the modulation of the signaling of the fibroblast growth factor receptor for corneal endothelial regeneration

The endothelial rejection and a critical shortage of crop grafts present a medical need not satisfied in the search area for the regeneration of the cornea. Although the basic fibroblast growth factor (BFGF) is a powerful mitogenic factor for ex vivo cornea expansion, it is also a morphogen with an unfavorable endothelial erronechmal transition (ENMT) of corneated endothelial cells. . A pharmacological reagent that retains the beneficial proliferator effect while missing from the ENMT effect of BFGF would be a great potential of the regeneration of the cornea.

In the current study, we have shown that BFGF has not only activated the canonical fibroblast growth factor receptor (FGFR1) of the Kinase Tyrosine pathway, but also a subsequent subsequent subsequent matrix metalloproteinase activity to cleave the N -Cadherine in N-terminal and C-terminal fragments, which activated the classic path of tyrosine kinase kinase and a cryptic β-catenin path to respectively affect the proliferation of the cornea and the ENMT. We generated the synthetic peptides resembling a critical pattern in the N-cadherin ectodomaine and found these peptides improved downstream of the proliferative signaling downstream of FGFR1 but without apparently ENMT effect.

The potential of these peptides can be demonstrated on the culture of the ex vivo cell and in the Cryo-Rat Vivo lesion model. Our study indicated that this peptidomimetic approach of N-cadherin can stimulate the regeneration of the cornea and offer a promising therapeutic option to treat endothelial dysfunction of the cornea.

 Fibroblast growth factor 10 is a negative regulator of postnatal neurogenesis in the mouse hypothalamus
Fibroblast growth factor 10 is a negative regulator of postnatal neurogenesis in the mouse hypothalamus

Dual Vascular Growth Factor of Growth Factors and Fibroblast Growth Factor Inhibition of the receiver causes antitumor immunity and improves the programmed cell of death-1 blockade control point in hepatocellular carcinoma

Context and objectives: combination of anti-angiogenic therapy with immune control block pads with anti-1 antibodies (PD-1), a promising treatment of hepatocellular carcinoma (HCC). Tyrosine Kinase inhibitors are well-known anti-angiogenic agents and offer combination potential with anti-PD-1 antibodies. This study examined any underlying immunomodulatory mechanisms of combined therapy.
Methods: HCC tissue samples for RNA sequencing (RNA-SEQ) were obtained from patients with differential predictions after anti-PD-1 treatment. Recombinant basic basic growth factor (BFGF) and vascular endothelial growth factor A (VEGFA) were used to stimulate T cells after the treatment of lenvatinib or sorafénib, respectively.

T The T cell function was analyzed by flow cytometry and lactate dehydrogenase test. In vivo experiments were conducted in Murine H22 and HEPA 1-6 skilled HCC models. Local immune infiltration in tumor microenvironment (TME) has been evaluated using multicolored flow cytometry. Gene regulation has been evaluated by RNA-SEQ. The microvascular density was measured by the immunohistochemistry and the induction of PD-1 ligand (PD-L1) was quantified by Western Blot.

Recombinant Mouse Fibroblast Growth Factor-9

CG036-101 1mg
EUR 8970

Recombinant Human Fibroblast Growth Factor-9

7-00358 5µg Ask for price

Recombinant Human Fibroblast Growth Factor-9

7-00359 20µg Ask for price

Recombinant Human Fibroblast Growth Factor-9

7-00360 1mg Ask for price

Recombinant Mouse Fibroblast Growth Factor-9

7-00361 2µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-9

7-00362 10µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-9

7-00363 1mg Ask for price

FGF-9 Fibroblast Growth Factor-9 Rat Recombinant Protein

PROTP36364 Regular: 10ug
EUR 380.4
Description: Rat FGF9 Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 207 amino acids and having a molecular mass of 23.3kDa.;The FGF-9 Mouse Recombinant is purified by proprietary chromatographic techniques.

Recombinant Human Fibroblast Growth Factor 9/FGF-9

C198-10ug 10ug
EUR 201.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Fibroblast Growth Factor 9/FGF-9

C198-1mg 1mg
EUR 2203.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Fibroblast Growth Factor 9/FGF-9

C198-500ug 500ug
EUR 1557.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Fibroblast Growth Factor 9/FGF-9

C198-50ug 50ug
EUR 486
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant rat Fibroblast growth factor 2

P1707 100ug Ask for price
Description: Recombinant protein for rat Fibroblast growth factor 2

Recombinant Rat Fibroblast Growth Factor-basic

7-00349 10µg Ask for price

Recombinant Rat Fibroblast Growth Factor-basic

7-00350 50µg Ask for price

Recombinant Rat Fibroblast Growth Factor-basic

7-00351 1mg Ask for price

FGF-9 Fibroblast Growth Factor-9 Human Recombinant Protein

PROTP31371 Regular: 20ug
EUR 380.4
Description: Fibroblast Growth Factor-9 Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 207 amino acids and having a molecular mass of 23.4 kDa. The FGF-9 is purified by proprietary chromatographic techniques.

FGF-9 Fibroblast Growth Factor-9 Mouse Recombinant Protein

PROTP54130 Regular: 10ug
EUR 380.4
Description: Fibroblast Growth Factor-9 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 205 amino acids and having a molecular mass of 23308 Dalton.;The FGF-9 Mouse Recombinant is purified by proprietary chromatographic techniques.

Recombinant Mouse Fibroblast Growth Factor 9/FGF-9(C-6His)

CR12-10ug 10ug
EUR 187.2
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,5%Trehalose,1mM EDTA,20%glycerol,1mM DTT,pH8.5 .

Recombinant Mouse Fibroblast Growth Factor 9/FGF-9(C-6His)

CR12-1mg 1mg
EUR 2252.4
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,5%Trehalose,1mM EDTA,20%glycerol,1mM DTT,pH8.5 .

Recombinant Mouse Fibroblast Growth Factor 9/FGF-9(C-6His)

CR12-500ug 500ug
EUR 1593.6
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,5%Trehalose,1mM EDTA,20%glycerol,1mM DTT,pH8.5 .

Recombinant Mouse Fibroblast Growth Factor 9/FGF-9(C-6His)

CR12-50ug 50ug
EUR 442.8
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,5%Trehalose,1mM EDTA,20%glycerol,1mM DTT,pH8.5 .

Recombinant Fibroblast Growth Factor 6 (FGF6)

4-RPA035Hu01
  • EUR 567.29
  • EUR 274.80
  • EUR 1797.31
  • EUR 679.10
  • EUR 1238.21
  • EUR 454.80
  • EUR 4313.28
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 6 expressed in: E.coli

Recombinant Fibroblast Growth Factor 6 (FGF6)

4-RPA035Ra01
  • EUR 601.69
  • EUR 284.40
  • EUR 1926.34
  • EUR 722.11
  • EUR 1324.22
  • EUR 477.60
  • EUR 4635.84
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Fibroblast Growth Factor 6 expressed in: E.coli

Recombinant Fibroblast Growth Factor 5 (FGF5)

4-RPA357Hu01
  • EUR 636.10
  • EUR 294.00
  • EUR 2055.36
  • EUR 765.12
  • EUR 1410.24
  • EUR 501.60
  • EUR 4958.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 5 expressed in: E.coli

Recombinant Fibroblast Growth Factor 4 (FGF4)

4-RPA034Bo01
  • EUR 668.35
  • EUR 302.40
  • EUR 2176.32
  • EUR 805.44
  • EUR 1490.88
  • EUR 523.20
  • EUR 5260.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Bovine Fibroblast Growth Factor 4 expressed in: E.coli

Recombinant Fibroblast Growth Factor 6 (FGF6)

4-RPA035Mu01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 6 expressed in: E.coli

Recombinant Fibroblast Growth Factor 3 (FGF3)

4-RPC906Hu01
  • EUR 528.58
  • EUR 265.20
  • EUR 1652.16
  • EUR 630.72
  • EUR 1141.44
  • EUR 429.60
  • EUR 3950.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 3 expressed in: E.coli

Recombinant Fibroblast Growth Factor 7 (FGF7)

4-RPA636Mu01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 7 expressed in: E.coli

Recombinant Human Fibroblast Growth Factor-4

7-00352 5µg Ask for price

Recombinant Human Fibroblast Growth Factor-4

7-00353 25µg Ask for price

Recombinant Human Fibroblast Growth Factor-4

7-00354 1mg Ask for price

Recombinant Human Fibroblast Growth Factor-8

7-00355 5µg Ask for price

Recombinant Human Fibroblast Growth Factor-8

7-00356 25µg Ask for price

Recombinant Human Fibroblast Growth Factor-8

7-00357 1mg Ask for price

Recombinant Human Fibroblast Growth Factor-19

CG027-005 5ug
EUR 351.6

Recombinant Human Fibroblast Growth Factor-19

CG027-025 25ug
EUR 489.6

Recombinant Human Fibroblast Growth Factor-19

CG027-101 1mg
EUR 10752

Recombinant Human Fibroblast Growth Factor-22

CG030-002 2ug
EUR 351.6

Recombinant Human Fibroblast Growth Factor-22

CG030-010 10ug
EUR 489.6

Recombinant Human Fibroblast Growth Factor-22

CG030-101 1mg
EUR 14154

Recombinant Mouse Fibroblast Growth Factor-15

7-00370 2µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-15

7-00371 10µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-15

7-00372 1mg Ask for price

Recombinant Mouse Fibroblast Growth Factor-18

7-00373 5µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-18

7-00374 25µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-18

7-00375 1mg Ask for price

Recombinant Human Fibroblast Growth Factor-19

7-00376 5µg Ask for price

Recombinant Human Fibroblast Growth Factor-19

7-00377 25µg Ask for price

Recombinant Human Fibroblast Growth Factor-19

7-00378 1mg Ask for price

Recombinant Human Fibroblast Growth Factor-21

7-00382 5µg Ask for price

Recombinant Human Fibroblast Growth Factor-21

7-00383 20µg Ask for price

Recombinant Human Fibroblast Growth Factor-21

7-00384 1mg Ask for price

Recombinant Mouse Fibroblast Growth Factor-21

7-00388 2µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-21

7-00389 10µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-21

7-00390 1mg Ask for price

Recombinant Human Fibroblast Growth Factor-22

7-00397 2µg Ask for price

Recombinant Human Fibroblast Growth Factor-22

7-00398 10µg Ask for price

Recombinant Human Fibroblast Growth Factor-22

7-00399 1mg Ask for price

Recombinant Human Fibroblast Growth Factor-23

7-00400 5µg Ask for price

Recombinant Human Fibroblast Growth Factor-23

7-00401 20µg Ask for price

Recombinant Human Fibroblast Growth Factor-23

7-00402 1mg Ask for price

Recombinant Human Fibroblast Growth Factor 12

7-00367 2µg Ask for price

Recombinant Human Fibroblast Growth Factor 12

7-00368 10µg Ask for price

Recombinant Human Fibroblast Growth Factor 12

7-00369 1mg Ask for price

Recombinant human Fibroblast growth factor 11

P1371 100ug Ask for price
Description: Recombinant protein for human Fibroblast growth factor 11

Recombinant human Fibroblast growth factor 16

P1372 100ug Ask for price
Description: Recombinant protein for human Fibroblast growth factor 16

Recombinant human Fibroblast growth factor 4

P1373 100ug Ask for price
Description: Recombinant protein for human Fibroblast growth factor 4

Recombinant human Fibroblast growth factor 3

P1374 100ug Ask for price
Description: Recombinant protein for human Fibroblast growth factor 3

Recombinant Fibroblast Growth Factor 15 (FGF15)

4-RPL154Ra01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Fibroblast Growth Factor 15 expressed in: E.coli

Recombinant Fibroblast Growth Factor 18 (FGF18)

4-RPC907Hu01
  • EUR 588.79
  • EUR 280.80
  • EUR 1877.95
  • EUR 705.98
  • EUR 1291.97
  • EUR 469.20
  • EUR 4514.88
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 18 expressed in: E.coli

Recombinant Fibroblast Growth Factor 22 (FGF22)

4-RPC909Hu01
  • EUR 466.21
  • EUR 248.40
  • EUR 1418.30
  • EUR 552.77
  • EUR 985.54
  • EUR 387.60
  • EUR 3365.76
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 22 expressed in: E.coli

Recombinant Fibroblast Growth Factor 22 (FGF22)

4-RPC909Mu01
  • EUR 560.83
  • EUR 273.60
  • EUR 1773.12
  • EUR 671.04
  • EUR 1222.08
  • EUR 451.20
  • EUR 4252.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 22 expressed in: E.coli

Recombinant Fibroblast Growth Factor 20 (FGF20)

4-RPC912Hu01
  • EUR 496.32
  • EUR 256.80
  • EUR 1531.20
  • EUR 590.40
  • EUR 1060.80
  • EUR 408.00
  • EUR 3648.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 20 expressed in: E.coli

Recombinant Fibroblast Growth Factor 11 (FGF11)

4-RPC913Hu01
  • EUR 601.69
  • EUR 284.40
  • EUR 1926.34
  • EUR 722.11
  • EUR 1324.22
  • EUR 477.60
  • EUR 4635.84
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 11 expressed in: E.coli

Recombinant Fibroblast Growth Factor 12 (FGF12)

4-RPC914Hu01
  • EUR 623.20
  • EUR 290.40
  • EUR 2006.98
  • EUR 748.99
  • EUR 1377.98
  • EUR 492.00
  • EUR 4837.44
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 12 expressed in: E.coli

Recombinant Fibroblast Growth Factor 13 (FGF13)

4-RPC915Hu01
  • EUR 711.36
  • EUR 314.40
  • EUR 2337.60
  • EUR 859.20
  • EUR 1598.40
  • EUR 552.00
  • EUR 5664.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 13 expressed in: E.coli

Recombinant Fibroblast Growth Factor 13 (FGF13)

4-RPC915Hu02
  • EUR 657.60
  • EUR 300.00
  • EUR 2136.00
  • EUR 792.00
  • EUR 1464.00
  • EUR 516.00
  • EUR 5160.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 13 expressed in: E.coli

Recombinant Fibroblast Growth Factor 13 (FGF13)

4-RPC915Ra01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Fibroblast Growth Factor 13 expressed in: E.coli

Recombinant Fibroblast Growth Factor 19 (FGF19)

4-RPC917Hu01
  • EUR 612.44
  • EUR 286.80
  • EUR 1966.66
  • EUR 735.55
  • EUR 1351.10
  • EUR 484.80
  • EUR 4736.64
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 19 expressed in: E.coli

Recombinant Fibroblast Growth Factor 21 (FGF21)

4-RPC918Hu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 21 expressed in: E.coli

Recombinant Fibroblast Growth Factor 21 (FGF21)

4-RPC918Mu02
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 21 expressed in: E.coli

Recombinant Fibroblast Growth Factor 21 (FGF21)

4-RPC918Po01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pig Fibroblast Growth Factor 21 expressed in: E.coli

Recombinant Fibroblast Growth Factor 21 (FGF21)

4-RPC918Ra01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Fibroblast Growth Factor 21 expressed in: E.coli

Recombinant Fibroblast Growth Factor 21 (FGF21)

4-RPC918Ra02
  • EUR 496.32
  • EUR 256.80
  • EUR 1531.20
  • EUR 590.40
  • EUR 1060.80
  • EUR 408.00
  • EUR 3648.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Fibroblast Growth Factor 21 expressed in: E.coli

Recombinant Fibroblast Growth Factor 10 (FGF10)

4-RPB882Hu01
  • EUR 588.79
  • EUR 280.80
  • EUR 1877.95
  • EUR 705.98
  • EUR 1291.97
  • EUR 469.20
  • EUR 4514.88
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 10 expressed in: E.coli

Recombinant Fibroblast Growth Factor 10 (FGF10)

4-RPB882Mu01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 10 expressed in: E.coli

Recombinant Fibroblast Growth Factor 10 (FGF10)

4-RPB882Ra01
  • EUR 633.95
  • EUR 292.80
  • EUR 2047.30
  • EUR 762.43
  • EUR 1404.86
  • EUR 499.20
  • EUR 4938.24
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Fibroblast Growth Factor 10 expressed in: E.coli

Recombinant Fibroblast Growth Factor 23 (FGF23)

4-RPA746Hu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 23 expressed in: E.coli

Recombinant Fibroblast Growth Factor 23 (FGF23)

4-RPA746Hu02
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 23 expressed in: E.coli

Recombinant Fibroblast Growth Factor 23 (FGF23)

4-RPA746Hu03
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 23 expressed in: E.coli

Recombinant Fibroblast Growth Factor 23 (FGF23)

4-RPA746Mu01
  • EUR 590.94
  • EUR 282.00
  • EUR 1886.02
  • EUR 708.67
  • EUR 1297.34
  • EUR 470.40
  • EUR 4535.04
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 23 expressed in: E.coli

Recombinant Human Fibroblast Growth Factor 4

HEGFP-0604 5ug Ask for price

Recombinant Bovine Fibroblast Growth Factor-21

7-00394 2µg Ask for price

Recombinant Bovine Fibroblast Growth Factor-21

7-00395 10µg Ask for price

Recombinant Bovine Fibroblast Growth Factor-21

7-00396 1mg Ask for price

Recombinant Human Fibroblast Growth Factor-basic

CG024-010 10ug
EUR 351.6

Recombinant Human Fibroblast Growth Factor-basic

CG024-050 50ug
EUR 489.6

Recombinant Human Fibroblast Growth Factor-basic

CG024-101 1mg
EUR 3300

Recombinant Mouse Fibroblast Growth Factor-basic

CG033-010 10ug
EUR 351.6

Recombinant Mouse Fibroblast Growth Factor-basic

CG033-050 50ug
EUR 489.6

Recombinant Mouse Fibroblast Growth Factor-basic

CG033-101 1mg
EUR 4110

Recombinant Human Fibroblast Growth Factor-basic

7-00331 10µg Ask for price

Recombinant Human Fibroblast Growth Factor-basic

7-00332 50µg Ask for price

Recombinant Human Fibroblast Growth Factor-basic

7-00333 1mg Ask for price

Recombinant Mouse Fibroblast Growth Factor-basic

7-00346 10µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-basic

7-00347 50µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-basic

7-00348 1mg Ask for price

Recombinant Human Fibroblast Growth Factor-acidic

7-00319 10µg Ask for price

Recombinant Human Fibroblast Growth Factor-acidic

7-00320 50µg Ask for price

Recombinant Human Fibroblast Growth Factor-acidic

7-00321 1mg Ask for price

Recombinant Mouse Fibroblast Growth Factor-acidic

7-00325 10µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-acidic

7-00326 50µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-acidic

7-00327 1mg Ask for price

Recombinant Bovine Fibroblast Growth Factor-basic

7-00340 10µg Ask for price

Recombinant Bovine Fibroblast Growth Factor-basic

7-00341 50µg Ask for price

Recombinant Bovine Fibroblast Growth Factor-basic

7-00342 1mg Ask for price

Recombinant human Isoform 9 of Fibroblast growth factor receptor 1

P1720 100ug Ask for price
Description: Recombinant protein for human Isoform 9 of Fibroblast growth factor receptor 1

Recombinant Fibroblast Growth Factor 2, Basic (FGF2)

4-RPA551Mu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 2, Basic expressed in: E.coli

Recombinant Fibroblast Growth Factor 2, Basic (FGF2)

4-RPA551Po01
  • EUR 700.61
  • EUR 310.80
  • EUR 2297.28
  • EUR 845.76
  • EUR 1571.52
  • EUR 544.80
  • EUR 5563.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pig Fibroblast Growth Factor 2, Basic expressed in: E.coli

Recombinant Fibroblast Growth Factor 2, Basic (FGF2)

4-RPA551Rb01
  • EUR 571.58
  • EUR 276.00
  • EUR 1813.44
  • EUR 684.48
  • EUR 1248.96
  • EUR 458.40
  • EUR 4353.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rabbit Fibroblast Growth Factor 2, Basic expressed in: E.coli

Recombinant Fibroblast Growth Factor 2, Basic (FGF2)

4-RPA551Bo01
  • EUR 636.10
  • EUR 294.00
  • EUR 2055.36
  • EUR 765.12
  • EUR 1410.24
  • EUR 501.60
  • EUR 4958.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Bovine Fibroblast Growth Factor 2, Basic expressed in: E.coli

Recombinant Fibroblast Growth Factor 2, Basic (FGF2)

4-RPA551Hu01
  • EUR 442.56
  • EUR 242.40
  • EUR 1329.60
  • EUR 523.20
  • EUR 926.40
  • EUR 372.00
  • EUR 3144.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 2, Basic expressed in: E.coli

Recombinant Human Fibroblast growth factor 10/FGF10

CR11-10ug 10ug
EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM Tris,200mM NaCl,pH8.0.

Recombinant Human Fibroblast growth factor 10/FGF10

CR11-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM Tris,200mM NaCl,pH8.0.

Recombinant Human Fibroblast growth factor 10/FGF10

CR11-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM Tris,200mM NaCl,pH8.0.

Recombinant Human Fibroblast growth factor 10/FGF10

CR11-50ug 50ug
EUR 442.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM Tris,200mM NaCl,pH8.0.

Recombinant Fibroblast Growth Factor 1, Acidic (FGF1)

4-RPA032Hu01
  • EUR 588.79
  • EUR 280.80
  • EUR 1877.95
  • EUR 705.98
  • EUR 1291.97
  • EUR 469.20
  • EUR 4514.88
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 1, Acidic expressed in: E.coli

Recombinant Fibroblast Growth Factor 1, Acidic (FGF1)

4-RPA032Mu01
  • EUR 642.55
  • EUR 295.20
  • EUR 2079.55
  • EUR 773.18
  • EUR 1426.37
  • EUR 505.20
  • EUR 5018.88
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor 1, Acidic expressed in: E.coli

Recombinant Fibroblast Growth Factor 1, Acidic (FGF1)

4-RPA032Ov01
  • EUR 633.95
  • EUR 292.80
  • EUR 2047.30
  • EUR 762.43
  • EUR 1404.86
  • EUR 499.20
  • EUR 4938.24
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Sheep Fibroblast Growth Factor 1, Acidic expressed in: E.coli

Recombinant Fibroblast Growth Factor 1, Acidic (FGF1)

4-RPA032Po01
  • EUR 668.35
  • EUR 302.40
  • EUR 2176.32
  • EUR 805.44
  • EUR 1490.88
  • EUR 523.20
  • EUR 5260.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pig Fibroblast Growth Factor 1, Acidic expressed in: E.coli

Recombinant Fibroblast Growth Factor 1, Acidic (FGF1)

4-RPA032Ra01
  • EUR 625.34
  • EUR 290.40
  • EUR 2015.04
  • EUR 751.68
  • EUR 1383.36
  • EUR 494.40
  • EUR 4857.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Fibroblast Growth Factor 1, Acidic expressed in: E.coli

Basic Fibroblast Growth Factor, Human recombinant, HEK

CA902-002 2 ug
EUR 238.8

Basic Fibroblast Growth Factor, Human recombinant, HEK

CA902-010 10 ug
EUR 360

Basic Fibroblast Growth Factor, Human recombinant, HEK

CA902-101 1 mg
EUR 7350

Recombinant Human Basic Fibroblast Growth Factor GMP

HEGFP-0605 5ug Ask for price

Recombinant Rat Fibroblast growth factor 23 Protein, His, E.coli-1mg

QP6045-ec-1mg 1mg
EUR 2763.6

Recombinant Human Fibroblast Growth Factor-19 His Tag

7-00379 5µg Ask for price

Recombinant Human Fibroblast Growth Factor-19 His Tag

7-00380 25µg Ask for price

Recombinant Human Fibroblast Growth Factor-19 His Tag

7-00381 1mg Ask for price

Recombinant Human Fibroblast Growth Factor-21, His Tag

7-00385 10µg Ask for price

Recombinant Human Fibroblast Growth Factor-21, His Tag

7-00386 50µg Ask for price

Recombinant Human Fibroblast Growth Factor-21, His Tag

7-00387 1mg Ask for price

Recombinant Mouse Fibroblast Growth Factor-21, His Tag

7-00391 2µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-21, His Tag

7-00392 10µg Ask for price

Results: The basic expression of the VEGF and fibroblast growth factor in patients with progressive disease was significantly higher than in patients with stable disease after anti-PD-1 treatment. VEGFA and BFGF have increased considerably the expression of the PD-1, the cytotoxic protein-4 and TIM-3 on T cells, while inhibiting Gamma Interferon (IFNG) and Granzyme secretion B and by removing the cytotoxicity of the T cell. This immunosuppressive effect has been returned by lenvatinib but not sorafénib. In addition, the double lenvatinib / anti-PD-1 antibody therapy led to better antitumor effects that the growth factor inhibitor of sorafenib or fibroblast (BGF398) (BGJ398) in HCC H22 murine models. The combined lenvatinib / anti-PD-1 treatment has also led to long-term immune formation, while synergistic modulation the TME and improves the cytotoxic effect of T cells. Finally, lenvatinib has inhibited the expression pd- L1 on endothelial human umbilical vein cells, which improved the function of T cells.

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