Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis

Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis

Background: Intermediate filament proteins that construct the nuclear lamina protein lamin cell including A / C is encoded by the gene LMNA, and is involved in fundamental processes such as nuclear structure, gene expression and signal transduction. LMNA mutations predominantly affect the mesoderm-derived cell lineages in diseases collectively referred to as laminopathies which include dilated cardiomyopathy with conduction defects, various forms of muscular dystrophy and premature aging syndromes as Hutchinson-Gilford Progeria Syndrome. At present, our understanding of the molecular mechanisms that regulate tissue-specific manifestations of laminopathies still limited.


Methods: To gain more insight into the molecular mechanisms of a novel splice-site mutations in LMNA (c.357-2A> G) in a family affected by heart disease, we do deep RNA sequencing and analysis for the nine lines derived fibroblast samples three patients with cardiomyopathy, three unaffected family members, and three unrelated individuals not affected. We validated our findings by the study of quantitative PCR and protein.


Results: We identified eight genes were significantly differentially expressed between fibroblasts mutant and non-mutant, which included downregulated factor insulin growth factor binding protein 5 (IGFBP5) in patient samples. ERK pathway analysis indicates involvement / MAPK signaling pathways consistent with previous studies. We found no significant differences in gene expression of lamin A / C and B-type lamins between groups. In the mutant fibroblasts, RNA-seq confirmed that only LMNA predominantly expressed wild-type allele, and Western blot showed normal levels of the protein lamin A / C


Conclusion:
IGFBP5 can contribute in maintaining homeostasis pathway signaling, which may cause the molecular and structural abnormalities is important in the network are not affected as fibroblasts. the mechanism of compensation of other nuclear membrane protein was not found. Our results also showed that only one copy of the wild allele kind enough to normal levels of the protein lamin A / C to maintain physiological functions in the cell type affected. This indicates that the affected cell types such as heart tissue may be more sensitive to haploinsufficiency of lamin A / C. These results provide insight into the molecular mechanisms of diseases with a possible explanation for tissue specificity LMNA related dilated cardiomyopathy.

 Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis
Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis

A novel multi-targeted tyrosine kinase inhibitor in combination with irinotecan anlotinib have in-vitro anti-tumor activity against lung cancer, small cell lung human

Anlotinib is a multi-targeted tyrosine kinase inhibitor developed independently in China. biological effects remain unclear in small cell lung cancer (SCLC). The current study aimed to evaluate the effects of anlotinib in combination with irinotecan in H446 and H2227 SCLC cell lines and provide new treatment strategies for SCLC. the growth of cells of the two cell lines was inhibited by anlotinib, irinotecan and the combination with a dose-dependent manner.

Human Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

DLR-FGF1-Hu-48T 48T
EUR 397.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Fibroblast Growth Factor 1, Acidic (FGF1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

DLR-FGF1-Hu-96T 96T
EUR 501.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Fibroblast Growth Factor 1, Acidic (FGF1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

DLR-FGF1-Mu-48T 48T
EUR 522
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Fibroblast Growth Factor 1, Acidic (FGF1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

DLR-FGF1-Mu-96T 96T
EUR 673.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Fibroblast Growth Factor 1, Acidic (FGF1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

DLR-FGF1-p-48T 48T
EUR 591.6
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Fibroblast Growth Factor 1, Acidic (FGF1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

DLR-FGF1-p-96T 96T
EUR 769.2
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Fibroblast Growth Factor 1, Acidic (FGF1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

DLR-FGF1-Ra-48T 48T
EUR 544.8
Description: A sandwich quantitative ELISA assay kit for detection of Rat Fibroblast Growth Factor 1, Acidic (FGF1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

DLR-FGF1-Ra-96T 96T
EUR 704.4
Description: A sandwich quantitative ELISA assay kit for detection of Rat Fibroblast Growth Factor 1, Acidic (FGF1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RD-FGF1-b-48Tests 48 Tests
EUR 592.8

Bovine Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RD-FGF1-b-96Tests 96 Tests
EUR 820.8

Chicken Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RD-FGF1-Ch-48Tests 48 Tests
EUR 540

Chicken Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RD-FGF1-Ch-96Tests 96 Tests
EUR 746.4

Human Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RD-FGF1-Hu-48Tests 48 Tests
EUR 373.2

Human Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RD-FGF1-Hu-96Tests 96 Tests
EUR 508.8

Mouse Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RD-FGF1-Mu-48Tests 48 Tests
EUR 514.8

Mouse Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RD-FGF1-Mu-96Tests 96 Tests
EUR 709.2

Porcine Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RD-FGF1-p-48Tests 48 Tests
EUR 592.8

Porcine Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RD-FGF1-p-96Tests 96 Tests
EUR 820.8

Rat Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RD-FGF1-Ra-48Tests 48 Tests
EUR 540

Rat Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RD-FGF1-Ra-96Tests 96 Tests
EUR 746.4

Bovine Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RDR-FGF1-b-48Tests 48 Tests
EUR 619.2

Bovine Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RDR-FGF1-b-96Tests 96 Tests
EUR 859.2

Chicken Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RDR-FGF1-Ch-48Tests 48 Tests
EUR 564

Chicken Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RDR-FGF1-Ch-96Tests 96 Tests
EUR 781.2

Human Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RDR-FGF1-Hu-48Tests 48 Tests
EUR 390

Human Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RDR-FGF1-Hu-96Tests 96 Tests
EUR 530.4

Mouse Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RDR-FGF1-Mu-48Tests 48 Tests
EUR 536.4

Mouse Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RDR-FGF1-Mu-96Tests 96 Tests
EUR 741.6

Porcine Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RDR-FGF1-p-48Tests 48 Tests
EUR 619.2

Porcine Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RDR-FGF1-p-96Tests 96 Tests
EUR 859.2

Rat Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RDR-FGF1-Ra-48Tests 48 Tests
EUR 564

Rat Fibroblast Growth Factor 1, Acidic (FGF1) ELISA Kit

RDR-FGF1-Ra-96Tests 96 Tests
EUR 781.2

FGF1

LF-PR013 10 ug
EUR 230.4
Description: FGF1 protein

FGF1 Antibody

1-CSB-PA449957
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:25-1:100

FGF1 Antibody

1-CSB-PA06379A0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA

FGF1 Antibody

1-CSB-PA008615ESR1HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:500, IF:1:50-1:200

FGF1 Antibody

1-CSB-PA008615ESR2HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:500, IF:1:50-1:200

FGF1 Antibody

1-CSB-PA008615GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC

Fgf1 Antibody

1-CSB-PA008615HA01MO
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf1. Recognizes Fgf1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

FGF1 Antibody

1-CSB-PA008237
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

FGF1 Antibody

DF6124 200ul
EUR 420

FGF1 siRNA

20-abx916815
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FGF1 siRNA

20-abx916816
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FGF1 Antibody

1-CSB-PA954065
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:50-1:200

Fgf1 antibody

70R-8011 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal Fgf1 antibody

Fgf1 antibody

70R-8030 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal Fgf1 antibody

FGF1 antibody

70R-12251 100 ug
EUR 483.6
Description: Rabbit polyclonal FGF 1 antibody

FGF1 antibody

70R-17289 50 ul
EUR 522
Description: Rabbit polyclonal FGF1 antibody

FGF1 antibody

70R-13668 100 ug
EUR 438
Description: Affinity purified Rabbit polyclonal FGF1 antibody

FGF1 antibody

70R-13853 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal FGF1 antibody

FGF1 antibody

38145-100ul 100ul
EUR 302.4

FGF1 protein

30R-2095 10 ug
EUR 326.4
Description: Purified recombinant Human Acidic Fibroblast Growth Factor

FGF1 protein

30R-2096 25 ug
EUR 564
Description: Purified recombinant Human Acidic Fibroblast Growth Factor

FGF1 protein

30R-2102 1 mg
EUR 7206
Description: Purified recombinant Human Acidic Fibroblast Growth Factor

FGF1 protein

30R-2334 50 ug
EUR 390
Description: Purified recombinant Human FGF1 protein

FGF1 protein

30R-2335 50 ug
EUR 390
Description: Purified recombinant Mouse FGF1 protein

FGF1 Antibody

36770-100ul 100ul
EUR 302.4

FGF1 antibody

10R-4098 100 ul
EUR 871.2
Description: Mouse monoclonal FGF1 antibody

FGF1 Antibody

ABD6124 100 ug
EUR 525.6

FGF1 siRNA

20-abx901949
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

pEGFP-FGF1

PVT17864 2 ug
EUR 309.6

anti-FGF1

YF-PA11765 50 ul
EUR 435.6
Description: Mouse polyclonal to FGF1

anti-FGF1

YF-PA11766 50 ug
EUR 435.6
Description: Mouse polyclonal to FGF1

anti-FGF1

YF-PA11767 100 ul
EUR 483.6
Description: Rabbit polyclonal to FGF1

anti-FGF1

YF-PA11768 100 ug
EUR 483.6
Description: Rabbit polyclonal to FGF1

anti-FGF1

YF-PA23703 50 ul
EUR 400.8
Description: Mouse polyclonal to FGF1

FGF1 Antibody

R30107 100 ug
EUR 419

FGF1 Antibody

R32394 100 ug
EUR 419

FGF1 Antibody

F49618-0.08ML 0.08 ml
EUR 165

FGF1 Antibody

F49618-0.4ML 0.4 ml
EUR 379

FGF1 Blocking Peptide

DF6124-BP 1mg
EUR 234

FGF1 cloning plasmid

CSB-CL008615HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the FGF1 gene.

anti- FGF1 antibody

FNab03087 100µg
EUR 658.5
Description: Antibody raised against FGF1

FGF1 Recombinant Protein

91-033 0.05 mg
EUR 437.1
Description: FGF acidic is a 17 kDa nonglycosylated member of the FGF family of mitogenic peptides. FGF acidic, which is produced by multiple cell types, stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It plays a number of roles in development, regeneration, and angiogenesis. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors.

FGF1 Recombinant Protein

91-039 0.05 mg
EUR 437.1
Description: FGF acidic, also known as ECGF, FGF-1and HBGF-1, is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. It is a mitogenic peptide that is produced by multiple cell types and stimulates the proliferation of cells of mesodermal, ectodermal, and endodermal origin. Its association with heparan sulfate is a prerequisite for activation of FGF receptors. Internalized FGF acidic migrates to the nucleus where it is phosphorylated by nuclear PKC delta, exported to the cytosol, dephosphorylated, and degraded. Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling.

FGF1 Recombinant Protein

92-269 0.05 mg
EUR 651.3
Description: FGF acidic, also known as ECGF, FGF-1and HBGF-1, is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. It is a mitogenic peptide that is produced by multiple cell types and stimulates the proliferation of cells of mesodermal, ectodermal, and endodermal origin. Its association with heparan sulfate is a prerequisite for activation of FGF receptors. Internalized FGF acidic migrates to the nucleus where it is phosphorylated by nuclear PKC delta, exported to the cytosol, dephosphorylated, and degraded. Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling.

FGF1 Rabbit pAb

A0685-100ul 100 ul
EUR 369.6

FGF1 Rabbit pAb

A0685-200ul 200 ul
EUR 550.8

FGF1 Rabbit pAb

A0685-20ul 20 ul
EUR 219.6

FGF1 Rabbit pAb

A0685-50ul 50 ul
EUR 267.6

Fgf1 Blocking Peptide

33R-1373 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Irf2bp1 antibody, catalog no. 70R-9319

Fgf1 Blocking Peptide

33R-5638 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Fgf1 antibody, catalog no. 70R-8011

Human FGF1 Antibody

32912-05111 150 ug
EUR 313.2

Human FGF1 Protein

abx060150-100ug 100 ug
EUR 610.8

FGF1 Recombinant Protein

96-016 0.2 mg
EUR 481.2
Description: Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF acidic is a potent growth factor for fibroblasts and endothelial cells. FGF acidic is involved in wound repair, angiogenesis, and development. FGF acidic is secreted from cells via an endoplasmic reticulum/Golgi independent mechanism. The ability of FGF acidic to bind to heparin sulfate is required for its ability to interact with FGF receptors and induce signaling. There are four distinct FGF receptors and each has multiple splice variants. FGF acidic binds with high affinity to many, but not all, FGFRs. Signaling cascades activated through FGF basic binding to FGFR include the ras-raf-MAPK, PLCγ/PKC, and PI3K/Akt pathways.

FGF1 Rabbit pAb

A0079-100ul 100 ul
EUR 369.6

FGF1 Rabbit pAb

A0079-200ul 200 ul
EUR 550.8

FGF1 Rabbit pAb

A0079-20ul 20 ul
EUR 219.6

FGF1 Rabbit pAb

A0079-50ul 50 ul
EUR 267.6

Anti-FGF1 Antibody

PA1311 100ug/vial
EUR 352.8

Anti-FGF1 Antibody

PB9241 100ug/vial
EUR 352.8

Anti-FGF1 Antibody

PB9944 100ug/vial
EUR 400.8

Anti-FGF1 antibody

PAab03087 100 ug
EUR 463.2

Anti-FGF1 antibody

STJ23650 100 µl
EUR 332.4
Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.

Anti-FGF1 antibody

STJ23651 100 µl
EUR 332.4
Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.

Anti-FGF1 Antibody

RP1005 100ug/vial
EUR 400.8

FGF1 Polyclonal Antibody

A71566-050 50 ul
EUR 302.5

FGF1 Polyclonal Antibody

A71566-100 100 ul
EUR 423.5

Anti-FGF1 (2E12)

YF-MA10321 100 ug
EUR 435.6
Description: Mouse monoclonal to FGF1

Anti-FGF1 (1F9)

YF-MA10322 100 ug
EUR 435.6
Description: Mouse monoclonal to FGF1

Anti-FGF1 (3F5)

YF-MA12986 100 ug
EUR 435.6
Description: Mouse monoclonal to FGF1

Fgf1 Polyclonal Antibody

A52780-020 20 ul Ask for price

Fgf1 Polyclonal Antibody

A52780-050 50 ul Ask for price

Fgf1 Polyclonal Antibody

A52780-100 100 ul
EUR 423.5

FGF1 Polyclonal Antibody

A55415-020 20 ul
EUR 117.7

FGF1 Polyclonal Antibody

A55415-050 50 ul
EUR 302.5

FGF1 Polyclonal Antibody

A55415-100 100 ul
EUR 423.5

Fgf1 Polyclonal Antibody

A52780
  • EUR 684.66
  • Ask for price
  • Ask for price
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

FGF1 Polyclonal Antibody

A55415
  • EUR 684.66
  • EUR 117.70
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

FGF1 Polyclonal Antibody

A71566
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

FGF1 Antibody, HRP conjugated

1-CSB-PA06379B0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

FGF1 Antibody, FITC conjugated

1-CSB-PA06379C0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

FGF1 Antibody, Biotin conjugated

1-CSB-PA06379D0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Fgf1 Antibody, HRP conjugated

1-CSB-PA008615HB01MO
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf1. Recognizes Fgf1 from Mouse. This antibody is HRP conjugated. Tested in the following application: ELISA

Fgf1 Antibody, FITC conjugated

1-CSB-PA008615HC01MO
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf1. Recognizes Fgf1 from Mouse. This antibody is FITC conjugated. Tested in the following application: ELISA

Fgf1 Antibody, Biotin conjugated

1-CSB-PA008615HD01MO
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Fgf1. Recognizes Fgf1 from Mouse. This antibody is Biotin conjugated. Tested in the following application: ELISA

Rat FGF1 shRNA Plasmid

20-abx984920
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse FGF1 shRNA Plasmid

20-abx970313
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human FGF1 shRNA Plasmid

20-abx951566
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

FGF1 protein (His tag)

80R-1948 100 ug
EUR 418.8
Description: Recombinant mouse FGF1 protein

FGF1 (Human) ELISA Kit

E4281-100
EUR 874.8

Human FGF1 ELISA Kit

ELA-E0032h 96 Tests
EUR 988.8

FGF1 ELISA KIT|Human

EF000328 96 Tests
EUR 826.8

pCMV-SPORT6-FGF1 Plasmid

PVT16693 2 ug
EUR 390

Human FGF1 PicoKine ELISA Kit

EK0339 96 wells
EUR 510
Description: For quantitative detection of human FGF1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Mouse FGF1 PicoKine ELISA Kit

EK1172 96 wells
EUR 510
Description: For quantitative detection of mouse FGF1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Rat FGF1 PicoKine ELISA Kit

EK1173 96 wells
EUR 510
Description: For quantitative detection of rat FGF1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

ELISA kit for Human FGF1

EK5141 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human FGF1 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Mouse FGF1

EK5507 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse FGF1 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Rat FGF1

EK5508 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat FGF1 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human FGF1 Antibody (Biotin Conjugate)

32912-05121 150 ug
EUR 442.8

FGF1 ELISA Kit (Mouse) (OKBB00520)

OKBB00520 96 Wells
EUR 606
Description: Description of target: Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. The FGF1 gene was mapped to chromosome 5q31.3-q33.2 by in situ hybridization.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

FGF1 ELISA Kit (Rat) (OKBB00521)

OKBB00521 96 Wells
EUR 606
Description: Description of target: Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. The FGF1 gene was mapped to chromosome 5q31.3-q33.2 by in situ hybridization.;Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

FGF1 ELISA Kit (Human) (OKBB00696)

OKBB00696 96 Wells
EUR 606
Description: Description of target: Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. The FGF1 gene was mapped to chromosome 5q31.3-q33.2 by in situ hybridization. ;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

FGF1 ELISA Kit (Horse) (OKBB00697)

OKBB00697 96 Wells
EUR 606
Description: Description of target: Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. The FGF1 gene was mapped to chromosome 5q31.3-q33.2 by in situ hybridization. ;Species reactivity: Horse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

FGF1 ELISA Kit (Monkey) (OKBB00698)

OKBB00698 96 Wells
EUR 606
Description: Description of target: Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. The FGF1 gene was mapped to chromosome 5q31.3-q33.2 by in situ hybridization. ;Species reactivity: Monkey;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

FGF1 ELISA Kit (Human) (OKAN04551)

OKAN04551 96 Wells
EUR 950.4
Description: Description of target: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.5 pg/mL

FGF1 ELISA Kit (Mouse) (OKAN05038)

OKAN05038 96 Wells
EUR 950.4
Description: Description of target: ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 5.7 pg/mL

FGF1 ELISA Kit (Rat) (OKAN05039)

OKAN05039 96 Wells
EUR 950.4
Description: Description of target: may play a role in neurite outgrowth; may regulate cell differentiation in the nervous system; may act in synergy with fibronectin to enhance neuronal cell adhesion [RGD, Feb 2006];Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.1 pg/mL

FGF1 ELISA Kit (Bovine) (OKCD05675)

OKCD05675 96 Wells
EUR 1248
Description: Description of target: Bovine Fibroblast Growth Factor-acidic;Species reactivity: Bovine;Application: ELISA;Assay info: ;Sensitivity: < 21.5pg/mL

FGF1 ELISA Kit (Goat) (OKCD05676)

OKCD05676 96 Wells
EUR 1090.8
Description: Description of target: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.;Species reactivity: Goat;Application: ELISA;Assay info: ;Sensitivity: < 31pg/mL

FGF1 ELISA Kit (Chicken) (OKCD05677)

OKCD05677 96 Wells
EUR 981.6
Description: Description of target: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.;Species reactivity: Chicken;Application: ELISA;Assay info: ;Sensitivity: < 17.63pg/mL

FGF1 ELISA Kit (Human) (OKCD05678)

OKCD05678 96 Wells
EUR 668.4
Description: Description of target: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 6.5pg/mL

FGF1 ELISA Kit (Mouse) (OKCD05679)

OKCD05679 96 Wells
EUR 934.8
Description: Description of target: The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 5.7pg/mL

FGF1 ELISA Kit (Pig) (OKCD05680)

OKCD05680 96 Wells
EUR 1248
Description: Description of target: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.;Species reactivity: Pig;Application: ELISA;Assay info: ;Sensitivity: < 6.1pg/mL

FGF1 ELISA Kit (Rat) (OKCD05681)

OKCD05681 96 Wells
EUR 981.6
Description: Description of target: The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: < 6.1pg/mL

FGF1 ELISA Kit (Mouse) (OKEH04095)

OKEH04095 96 Wells
EUR 715.2
Description: Description of target: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.6 pg/mL

Fgf1 ELISA Kit (Rat) (OKEH04535)

OKEH04535 96 Wells
EUR 715.2
Description: Description of target: May play a role in neurite outgrowth; may regulate cell differentiation in the nervous system; may act in synergy with fibronectin to enhance neuronal cell adhesion.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.6 pg/mL

Fgf1 ORF Vector (Rat) (pORF)

ORF067089 1.0 ug DNA
EUR 607.2

FGF1 ELISA Kit (Dog) (OKEH06345)

OKEH06345 96 Wells
EUR 934.8
Description: Description of target: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 32 pg/mL

FGF1 ELISA Kit (Bovine) (OKEH06352)

OKEH06352 96 Wells
EUR 934.8
Description: Description of target: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.;Species reactivity: Bovine;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.053 ng/mL

FGF1 ELISA Kit (Chicken) (OKEH07236)

OKEH07236 96 Wells
EUR 1420.8
Description: Description of target: ;Species reactivity: Chicken;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 39pg/mL

FGF1 ELISA Kit (Pig) (OKEH07237)

OKEH07237 96 Wells
EUR 1310.4
Description: Description of target: ;Species reactivity: Pig;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 19pg/mL

FGF1 ORF Vector (Human) (pORF)

ORF004031 1.0 ug DNA
EUR 114

Fgf1 ORF Vector (Mouse) (pORF)

ORF044809 1.0 ug DNA
EUR 607.2

Fgf1 Polyclonal Antibody, Biotin Conjugated

A52777-050 50 ul
EUR 302.5

Fgf1 Polyclonal Antibody, Biotin Conjugated

A52777-100 100 ul
EUR 423.5

Fgf1 Polyclonal Antibody, FITC Conjugated

A52778-050 50 ul
EUR 302.5

Fgf1 Polyclonal Antibody, FITC Conjugated

A52778-100 100 ul
EUR 423.5

Fgf1 Polyclonal Antibody, HRP Conjugated

A52779-050 50 ul
EUR 302.5

Fgf1 Polyclonal Antibody, HRP Conjugated

A52779-100 100 ul
EUR 423.5

FGF1 Polyclonal Antibody, HRP Conjugated

A55416-050 50 ul
EUR 302.5

FGF1 Polyclonal Antibody, HRP Conjugated

A55416-100 100 ul
EUR 423.5

FGF1 Polyclonal Antibody, FITC Conjugated

A55417-050 50 ul
EUR 302.5

FGF1 Polyclonal Antibody, FITC Conjugated

A55417-100 100 ul
EUR 423.5

FGF1 Polyclonal Antibody, Biotin Conjugated

A55418-050 50 ul
EUR 302.5

FGF1 Polyclonal Antibody, Biotin Conjugated

A55418-100 100 ul
EUR 423.5

Fgf1 Polyclonal Antibody, Biotin Conjugated

A52777
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Fgf1 Polyclonal Antibody, FITC Conjugated

A52778
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Fgf1 Polyclonal Antibody, HRP Conjugated

A52779
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

FGF1 Polyclonal Antibody, HRP Conjugated

A55416
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

FGF1 Polyclonal Antibody, FITC Conjugated

A55417
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

FGF1 Polyclonal Antibody, Biotin Conjugated

A55418
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Human Fibroblast growth factor 1 (FGF1)

1-CSB-EP008615HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Fibroblast growth factor 1(FGF1) expressed in E.coli

Human Fibroblast growth factor 1 (FGF1)

1-CSB-EP008615HUc7
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Fibroblast growth factor 1(FGF1) expressed in E.coli

Mouse Fibroblast growth factor 1 (Fgf1)

1-CSB-EP008615MO
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Fibroblast growth factor 1(Fgf1) expressed in E.coli

FGF1 Intracellular-Binding Protein Recombinant Protein

92-063 0.05 mg
EUR 852.9
Description: Acidic Fibroblast Growth Factor Intracellular-Binding Protein (FIBP) is highly expressed in the heart, skeletal muscle, and pancreas. Acidic Fibroblast Growth Factor is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FIBP is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF.

Human FGF1 AssayLite Antibody (FITC Conjugate)

32912-05141 150 ug
EUR 513.6

Human FGF1 AssayLite Antibody (RPE Conjugate)

32912-05151 150 ug
EUR 513.6

Human FGF1 AssayLite Antibody (APC Conjugate)

32912-05161 150 ug
EUR 513.6

Human FGF1 AssayLite Antibody (PerCP Conjugate)

32912-05171 150 ug
EUR 565.2

Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx109783
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx109784
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx112524
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx000547
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx000820
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Fibroblast Growth Factor 1 (FGF1) Antibody

abx233087-100ug 100 ug
EUR 610.8

Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx320141
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx322141
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx326446
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

After 72 hours of incubation, the degree of inhibition was greater in the combination group than all the single drug groups. Similar results were found when apoptosis was assessed after 12 h, but not after 6 hours of treatment. Compared with a single drug, drug combination suppressed the migration and invasion ability in two cell lines; However, there is no difference between anlotinib individual or irinotecan. Colony formation rates clearly lowered in the combination group.

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