Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis

Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis

Background: Intermediate filament proteins that construct the nuclear lamina protein lamin cell including A / C is encoded by the gene LMNA, and is involved in fundamental processes such as nuclear structure, gene expression and signal transduction. LMNA mutations predominantly affect the mesoderm-derived cell lineages in diseases collectively referred to as laminopathies which include dilated cardiomyopathy with conduction defects, various forms of muscular dystrophy and premature aging syndromes as Hutchinson-Gilford Progeria Syndrome. At present, our understanding of the molecular mechanisms that regulate tissue-specific manifestations of laminopathies still limited.


Methods: To gain more insight into the molecular mechanisms of a novel splice-site mutations in LMNA (c.357-2A> G) in a family affected by heart disease, we do deep RNA sequencing and analysis for the nine lines derived fibroblast samples three patients with cardiomyopathy, three unaffected family members, and three unrelated individuals not affected. We validated our findings by the study of quantitative PCR and protein.


Results: We identified eight genes were significantly differentially expressed between fibroblasts mutant and non-mutant, which included downregulated factor insulin growth factor binding protein 5 (IGFBP5) in patient samples. ERK pathway analysis indicates involvement / MAPK signaling pathways consistent with previous studies. We found no significant differences in gene expression of lamin A / C and B-type lamins between groups. In the mutant fibroblasts, RNA-seq confirmed that only LMNA predominantly expressed wild-type allele, and Western blot showed normal levels of the protein lamin A / C


Conclusion:
IGFBP5 can contribute in maintaining homeostasis pathway signaling, which may cause the molecular and structural abnormalities is important in the network are not affected as fibroblasts. the mechanism of compensation of other nuclear membrane protein was not found. Our results also showed that only one copy of the wild allele kind enough to normal levels of the protein lamin A / C to maintain physiological functions in the cell type affected. This indicates that the affected cell types such as heart tissue may be more sensitive to haploinsufficiency of lamin A / C. These results provide insight into the molecular mechanisms of diseases with a possible explanation for tissue specificity LMNA related dilated cardiomyopathy.

 Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis
Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis

A novel multi-targeted tyrosine kinase inhibitor in combination with irinotecan anlotinib have in-vitro anti-tumor activity against lung cancer, small cell lung human

Anlotinib is a multi-targeted tyrosine kinase inhibitor developed independently in China. biological effects remain unclear in small cell lung cancer (SCLC). The current study aimed to evaluate the effects of anlotinib in combination with irinotecan in H446 and H2227 SCLC cell lines and provide new treatment strategies for SCLC. the growth of cells of the two cell lines was inhibited by anlotinib, irinotecan and the combination with a dose-dependent manner.

FGF1

MBS516997-1mg 1mg
EUR 1490

FGF1

MBS516997-5x1mg 5x1mg
EUR 6450

FGF1

MBS8563166-01mLAF405L 0.1mL(AF405L)
EUR 565

FGF1

MBS8563166-01mLAF405S 0.1mL(AF405S)
EUR 565

FGF1

MBS8563166-01mLAF610 0.1mL(AF610)
EUR 565

FGF1

MBS8563166-01mLAF635 0.1mL(AF635)
EUR 565

FGF1

MBS8563166-02mL 0.2mL
EUR 345

FGF1

PA1311 100μg
EUR 260

FGF1

PA1311-M 100μg
EUR 290
Description: Polyclonal Antibodies Conjugated to Magnetic Beads

FGF1

PA1311-S 100μg
EUR 290
Description: Polyclonal Antibodies Conjugated to Sepharose Beads

FGF1, Sf9

cyt-364 2µg
EUR 60
Description: Recombinant Human Fibroblast Growth Factor-acidic, Sf9

FGF1 protein

30R-2095 10 ug
EUR 316
Description: Purified recombinant Human Acidic Fibroblast Growth Factor

FGF1 protein

30R-2096 25 ug
EUR 586
Description: Purified recombinant Human Acidic Fibroblast Growth Factor

FGF1 protein

30R-2102 1 mg
EUR 7160
Description: Purified recombinant Human Acidic Fibroblast Growth Factor

FGF1 protein

30R-2334 50 ug
EUR 265
Description: Purified recombinant Human FGF1 protein

FGF1 protein

30R-2335 50 ug
EUR 125
Description: Purified recombinant Mouse FGF1 protein

FGF1 protein

MBS836344-001mg 0.01mg
EUR 550

FGF1 protein

MBS836344-5x001mg 5x0.01mg
EUR 2325

FGF1 protein

MBS837020-0025mg 0.025mg
EUR 960

FGF1 protein

MBS837020-5x0025mg 5x0.025mg
EUR 4175

FGF1 protein

MBS837178-1mg 1mg
EUR 10625

FGF1 antibody

38145 100ul
EUR 439

FGF1 antibody

38145-100ul 100ul
EUR 302.4

FGF1 Antibody

36770 100ul
EUR 319

FGF1 Antibody

36770-100ul 100ul
EUR 302.4

FGF1 antibody

70R-17289 50 ul
EUR 289
Description: Rabbit polyclonal FGF1 antibody

FGF1 antibody

70R-12251 100 ug
EUR 343
Description: Rabbit polyclonal FGF 1 antibody

FGF1 antibody

70R-13668 100 ug
EUR 492
Description: Affinity purified Rabbit polyclonal FGF1 antibody

FGF1 antibody

70R-13853 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal FGF1 antibody

Fgf1 antibody

70R-8011 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal Fgf1 antibody

Fgf1 antibody

70R-8030 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal Fgf1 antibody

FGF1 Antibody

ABD6124 100 ug
EUR 525.6

FGF1 antibody

10R-4098 100 ul
EUR 709
Description: Mouse monoclonal FGF1 antibody

FGF1 Antibody

1-CSB-PA008237
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  • 50ug
  • 100ug
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

FGF1 Antibody

1-CSB-PA008615ESR1HU
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  • 100ul
  • 50ul
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:500, IF:1:50-1:200

FGF1 Antibody

1-CSB-PA008615ESR2HU
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  • 100ul
  • 50ul
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:500, IF:1:50-1:200

FGF1 Antibody

1-CSB-PA008615GA01HU
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  • 50ul
  • 150ul
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC

Fgf1 Antibody

1-CSB-PA008615HA01MO
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  • 50ug
  • 100ug
Description: A polyclonal antibody against Fgf1. Recognizes Fgf1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

fgf1 Antibody

CSB-PA754234XA01DIL-02mg 0.2mg Ask for price
Description: Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) fgf1 protein

fgf1 Antibody

CSB-PA754234XA01DIL-10mg 10mg Ask for price
Description: Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) fgf1 protein

FGF1 Antibody

1-CSB-PA449957
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  • 50ul
  • 100ul
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:25-1:100

FGF1 Antibody

DF6124 200ul
EUR 420

FGF1 Antibody

DF6124-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

FGF1 Antibody

DF6124-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

Fgf1 Antibody

CAC07350-100ug 100ug
EUR 314

Fgf1 Antibody

CAC07350-50ug 50ug
EUR 199.2

FGF1 Antibody

1-CSB-PA06379A0Rb
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  • 100ug
  • 50ug
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA

FGF1 Antibody

1-CSB-PA954065
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  • 50ul
  • 100ul
Description: A polyclonal antibody against FGF1. Recognizes FGF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:50-1:200

FGF1 Antibody

GWB-AB2F00 0.1 ml Ask for price

Fgf1 Antibody

GWB-ML710H 50ug Ask for price

Fgf1 Antibody

GWB-ML827H 50ug Ask for price

FGF1 Antibody

E036770 100μg/100μl
EUR 255
Description: Available in various conjugation types.

FGF1 Antibody

E311038 200ul
EUR 275
Description: Available in various conjugation types.

FGF1 Antibody

E38PA6280 100ul
EUR 225
Description: Available in various conjugation types.

FGF1 Antibody

E19-6124 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FGF1 Antibody

E90685 100ul
EUR 255
Description: Available in various conjugation types.

FGF1 Antibody

MBS5311578-01mg 0.1mg
EUR 470

FGF1 Antibody

MBS5311578-5x01mg 5x0.1mg
EUR 2080

FGF1 Antibody

MBS5312506-01mg 0.1mg
EUR 915

FGF1 Antibody

MBS5312506-5x01mg 5x0.1mg
EUR 3975

FGF1 Antibody

MBS2523265-006mL 0.06mL
EUR 180

FGF1 Antibody

MBS2523265-012mL 0.12mL
EUR 255

FGF1 Antibody

MBS2523265-02mL 0.2mL
EUR 400

FGF1 Antibody

MBS2523265-5x02mL 5x0.2mL
EUR 1715

FGF1 Antibody

MBS7126911-005mL 0.05mL
EUR 190

FGF1 Antibody

MBS7126911-01mL 0.1mL
EUR 270

FGF1 Antibody

MBS7126911-5x01mL 5x0.1mL
EUR 1205

FGF1 Antibody

MBS7126912-005mL 0.05mL
EUR 190

FGF1 Antibody

MBS7126912-01mL 0.1mL
EUR 270

FGF1 Antibody

MBS7126912-5x01mL 5x0.1mL
EUR 1205

FGF1 Antibody

MBS7119195-005mg 0.05mg
EUR 150

FGF1 Antibody

MBS7119195-01mg 0.1mg
EUR 190

FGF1 Antibody

MBS7119195-5x01mg 5x0.1mg
EUR 845

FGF1 Antibody

MBS8583969-01mL 0.1mL
EUR 305

FGF1 Antibody

MBS8583969-01mLAF405L 0.1mL(AF405L)
EUR 465

FGF1 Antibody

MBS8583969-01mLAF405S 0.1mL(AF405S)
EUR 465

FGF1 Antibody

MBS8583969-01mLAF610 0.1mL(AF610)
EUR 465

FGF1 Antibody

MBS8583969-01mLAF635 0.1mL(AF635)
EUR 465

FGF1 Antibody

MBS9606784-01mL 0.1mL
EUR 260

FGF1 Antibody

MBS9606784-02mL 0.2mL
EUR 305

FGF1 Antibody

MBS9606784-5x02mL 5x0.2mL
EUR 1220

FGF1 Antibody

MBS8516041-01mg 0.1mg
EUR 305

FGF1 Antibody

MBS8516041-01mLAF405L 0.1mL(AF405L)
EUR 465

FGF1 Antibody

MBS8516041-01mLAF405S 0.1mL(AF405S)
EUR 465

FGF1 Antibody

MBS8516041-01mLAF610 0.1mL(AF610)
EUR 465

FGF1 Antibody

MBS8516041-01mLAF635 0.1mL(AF635)
EUR 465

FGF1 antibody

MBS832001-01mL 0.1mL
EUR 1095

FGF1 antibody

MBS832001-5x01mL 5x0.1mL
EUR 4770

FGF1 Antibody

MBS8504270-01mL 0.1mL
EUR 325

FGF1 Antibody

MBS8504270-01mLAF405L 0.1mL(AF405L)
EUR 565

FGF1 Antibody

MBS8504270-01mLAF405S 0.1mL(AF405S)
EUR 565

FGF1 Antibody

MBS8504270-01mLAF610 0.1mL(AF610)
EUR 565

FGF1 Antibody

MBS8504270-01mLAF635 0.1mL(AF635)
EUR 565

FGF1 Antibody

MBS9407479-01mL 0.1mL
EUR 305

FGF1 Antibody

MBS9407479-5x01mL 5x0.1mL
EUR 1230

FGF1 antibody

MBS9410679-005mL 0.05mL
EUR 300

FGF1 antibody

MBS9410679-01mL 0.1mL
EUR 390

FGF1 antibody

MBS9410679-5x01mL 5x0.1mL
EUR 1610

FGF1 155 a.a.

cyt-1112 10µg
EUR 60
Description: Recombinant Human Fibroblast Growth Factor-acidic (155 a.a.)

FGF1 Rat mAb

E2230024 100ul
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rat FGF1 siRNA

20-abx916815
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  • 15 nmol
  • 30 nmol

FGF1 siRNA (Rat)

MBS8225926-15nmol 15nmol
EUR 405

FGF1 siRNA (Rat)

MBS8225926-30nmol 30nmol
EUR 565

FGF1 siRNA (Rat)

MBS8225926-5x30nmol 5x30nmol
EUR 2450

FGF1 Rabbit mAb

A24616 200μL
EUR 88.56

FGF1 Rabbit pAb

A0079 20μL
EUR 173.58

FGF1 Rabbit pAb

A0079-200ul 200 ul
EUR 550.8

FGF1 Rabbit pAb

A0079-20ul 20 ul
EUR 219.6

FGF1 Rabbit mAb

A23167 200μL
EUR 1657.89
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 24-96 of mouse CD59a (NP_031678.1).

FGF1 Rabbit mAb

52282 100ul
EUR 499

FGF1 Rabbit mAb

59685 100ul
EUR 339

FGF1 Rabbit pAb

A0685 1000μL
EUR 88.56

FGF1 Rabbit pAb

A0685-200ul 200 ul
EUR 550.8

FGF1 Rabbit pAb

A0685-20ul 20 ul
EUR 219.6

FGF1 cDNA Clone

MBS1271449-001mgPlasmid02mLGlycerolStock 0.01mgPlasmid+0.2mLGlycerol-Stock
EUR 200

FGF1 cDNA Clone

MBS1271449-5x001mgPlasmid5x02mLGlycerolStock 5x0.01mgPlasmid+5x0.2mLGlycerol-Stock
EUR 855

FGF1 Rabbit pAb

E2382220 100ul
EUR 225
Description: Available in various conjugation types.

FGF1 Rabbit mAb

E38A4436 100ug/100ul
EUR 255

FGF1 Rabbit mAb

E2R24301 100ul
EUR 255
Description: Available in various conjugation types.

FGF1 Rabbit mAb

E2R382220 100ul
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

FGF1 Rabbit pAb

E2500685 100ul
EUR 225
Description: Available in various conjugation types.

FGF1 Rabbit pAb

E47R0229 100ul
EUR 295

FGF1 Rabbit mAb

E45R12360N 50 ul
EUR 346.5

FGF1 Rabbit pAb

E45R17516N 50 ul
EUR 297.75

FGF1 Rabbit mAb

MBS9466995-005mL 0.05mL
EUR 290

FGF1 Rabbit mAb

MBS9466995-01mL 0.1mL
EUR 435

FGF1 Rabbit mAb

MBS9466995-5x01mL 5x0.1mL
EUR 1810

FGF1 Rabbit pAb

MBS8543679-01mL 0.1mL
EUR 305

FGF1 Rabbit pAb

MBS8543679-01mLAF405L 0.1mL(AF405L)
EUR 565

FGF1 Rabbit pAb

MBS8543679-01mLAF405S 0.1mL(AF405S)
EUR 565

FGF1 Rabbit pAb

MBS8543679-01mLAF610 0.1mL(AF610)
EUR 565

FGF1 Rabbit pAb

MBS8543679-01mLAF635 0.1mL(AF635)
EUR 565

FGF1 Rabbit pAb

MBS8544083-01mL 0.1mL
EUR 305

FGF1 Rabbit pAb

MBS8544083-01mLAF405L 0.1mL(AF405L)
EUR 565

FGF1 Rabbit pAb

MBS8544083-01mLAF405S 0.1mL(AF405S)
EUR 565

FGF1 Rabbit pAb

MBS8544083-01mLAF610 0.1mL(AF610)
EUR 565

FGF1 Rabbit pAb

MBS8544083-01mLAF635 0.1mL(AF635)
EUR 565

Mouse FGF1 siRNA

20-abx916816
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  • 15 nmol
  • 30 nmol

Human FGF1 siRNA

20-abx901949
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  • 15 nmol
  • 30 nmol

FGF1 siRNA (Human)

MBS8217507-15nmol 15nmol
EUR 405

FGF1 siRNA (Human)

MBS8217507-30nmol 30nmol
EUR 565

FGF1 siRNA (Human)

MBS8217507-5x30nmol 5x30nmol
EUR 2450

FGF1 siRNA (Mouse)

MBS8214981-15nmol 15nmol
EUR 405

FGF1 siRNA (Mouse)

MBS8214981-30nmol 30nmol
EUR 565

FGF1 siRNA (Mouse)

MBS8214981-5x30nmol 5x30nmol
EUR 2450

Fgf1 (GFP-tagged) - Mouse fibroblast growth factor 1 (Fgf1)

MG201152 10 µg Ask for price

Fgf1 (untagged) - Mouse fibroblast growth factor 1 (Fgf1), (10ug)

MC203263 10 µg Ask for price

Human FGF1 Protein

abx060150-100g 100 µg Ask for price

Human FGF1 Protein

abx060150-100ug 100 ug
EUR 610.8

Human FGF1 Protein

abx060150-10g 10 µg
EUR 437.5

Human FGF1 Protein

abx060150-50g 50 µg Ask for price

anti- FGF1 antibody

FNab03087 100µg
EUR 658.5
Description: Antibody raised against FGF1

Mouse FGF1 Protein

E40MOP1176 20ug
EUR 495

Human FGF1 Protein

E40KMPH1136 20ug
EUR 495

Mouse FGF1 Protein

PRP1152-100ug 100 μg
EUR 149

Mouse FGF1 Protein

PRP1152-1mg 1 mg
EUR 999

Mouse FGF1 Protein

PRP1152-20ug 20 μg
EUR 59

Mouse FGF1 Protein

PRP1152-500ug 500 μg
EUR 569

Human FGF1 Antibody

32912-05111 150 ug
EUR 215

Canine FGF1 Protein

E40PCA160 20ug
EUR 495

FGF1 cloning plasmid

CSB-CL008615HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the FGF1 gene.

Recombinant Rat FGF1

MBS7610143-005mg 0.05mg
EUR 345

Recombinant Rat FGF1

MBS7610143-02mg 0.2mg
EUR 635

Recombinant Rat FGF1

MBS7610143-1mg 1mg
EUR 1800

Recombinant Rat FGF1

MBS7610143-5x1mg 5x1mg
EUR 6955

Fgf1 Blocking Peptide

33R-5638 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Fgf1 antibody, catalog no. 70R-8011

Fgf1 Blocking Peptide

33R-1373 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Irf2bp1 antibody, catalog no. 70R-9319

FGF1 Blocking Peptide

DF6124-BP 1mg
EUR 234

FGF1 Blocking Peptide

MBS9625501-1mg 1mg
EUR 380

FGF1 Blocking Peptide

MBS9625501-5x1mg 5x1mg
EUR 1650

FGF1 Blocking Peptide

MBS8309597-1mg 1mg
EUR 190

FGF1 Blocking Peptide

MBS8309597-5mg 5mg
EUR 345

FGF1 Blocking Peptide

MBS8309597-5x5mg 5x5mg
EUR 1465

Recombinant Mouse FGF1

MBS4159917-005mg 0.05mg
EUR 230

Recombinant Mouse FGF1

MBS4159917-02mg 0.2mg
EUR 445

Recombinant Mouse FGF1

MBS4159917-1mg 1mg
EUR 950

Recombinant Mouse FGF1

MBS4159917-5x1mg 5x1mg
EUR 4025

Recombinant Human FGF1

MBS4159630-005mg 0.05mg
EUR 195

Recombinant Human FGF1

MBS4159630-025mg 0.25mg
EUR 325

Recombinant Human FGF1

MBS4159630-1mg 1mg
EUR 845

Recombinant Human FGF1

MBS4159630-5x1mg 5x1mg
EUR 3550

Recombinant Human FGF1

MBS7614198-005mg 0.05mg
EUR 345

Recombinant Human FGF1

MBS7614198-02mg 0.2mg
EUR 635

Recombinant Human FGF1

MBS7614198-1mg 1mg
EUR 1800

Recombinant Human FGF1

MBS7614198-5x1mg 5x1mg
EUR 6955

Recombinant Human FGF1

Z100005 50 µg
EUR 50
Description: aFGF and bFGF display 55% homology which is limited, however, to a few functional domains. The structure of aFGF, revealed by X-ray crystallography, shows a similar folding structure as IL1. Because aFGF binds to the same receptor as bFGF, aFGF displays more or less the same spectrum of activities. It is, however, generally less active than bFGF in similar assays. FGF receptors are encoded by a gene family consisting of at least four receptor tyrosine kinases that transduce signals important in a variety of developmental and physiological processes related to cell growth and differentiation. Recombinant Human FGF1 is a single polypeptide of 16 kDa.

Recombinant Human FGF1

Z100007 250 µg
EUR 180
Description: aFGF and bFGF display 55% homology which is limited, however, to a few functional domains. The structure of aFGF, revealed by X-ray crystallography, shows a similar folding structure as IL1. Because aFGF binds to the same receptor as bFGF, aFGF displays more or less the same spectrum of activities. It is, however, generally less active than bFGF in similar assays. FGF receptors are encoded by a gene family consisting of at least four receptor tyrosine kinases that transduce signals important in a variety of developmental and physiological processes related to cell growth and differentiation. Recombinant Human FGF1 is a single polypeptide of 16 kDa.

Recombinant Human FGF1

Z100009 1.0 mg
EUR 630
Description: aFGF and bFGF display 55% homology which is limited, however, to a few functional domains. The structure of aFGF, revealed by X-ray crystallography, shows a similar folding structure as IL-1. Because aFGF binds to the same receptor as bFGF, aFGF displays more or less the same spectrum of activities. It is, however, generally less active than bFGF in similar assays. FGF receptors are encoded by a gene family consisting of at least four receptor tyrosine kinases that transduce signals important in a variety of developmental and physiological processes related to cell growth and differentiation.

Recombinant Mouse FGF1

Z200005 50 µg
EUR 85
Description: aFGF and bFGF display 55 % homology which is limited, however, to a few functional domains. The structure of aFGF, revealed by X-ray crystallography, shows a similar folding structure as IL-1. Because aFGF binds to the same receptor as bFGF, aFGF displays more or less the same spectrum of activities. It is, however, generally less active than bFGF in similar assays. FGF receptors are encoded by a gene family consisting of at least four receptor tyrosine kinases that transduce signals important in a variety of developmental and physiological processes related to cell growth and differentiation.

Recombinant Mouse FGF1

Z200007 200 µg
EUR 285
Description: aFGF and bFGF display 55 % homology which is limited, however, to a few functional domains. The structure of aFGF, revealed by X-ray crystallography, shows a similar folding structure as IL-1. Because aFGF binds to the same receptor as bFGF, aFGF displays more or less the same spectrum of activities. It is, however, generally less active than bFGF in similar assays. FGF receptors are encoded by a gene family consisting of at least four receptor tyrosine kinases that transduce signals important in a variety of developmental and physiological processes related to cell growth and differentiation.

After 72 hours of incubation, the degree of inhibition was greater in the combination group than all the single drug groups. Similar results were found when apoptosis was assessed after 12 h, but not after 6 hours of treatment. Compared with a single drug, drug combination suppressed the migration and invasion ability in two cell lines; However, there is no difference between anlotinib individual or irinotecan. Colony formation rates clearly lowered in the combination group.

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