Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways

Regulation of the epidermal growth factor (EGF) receptor (EGFR) signaling is essential for the replication of human cytomegalovirus (HCMV) and the latency and reactivation in CD34 + hematopoietic progenitor cells. HCMV microRNAs (miRNAs) provide a means to modulate the signal is activated by EGF through targeting EGFR signaling pathway components. Here, we show that miR-US5-2 HCMV immediate critical downregulates EGFR GAB1 adapter proteins that mediate sustained activation and signals through phosphatidylinositol 3-kinase (PI3K) and MEK / extracellular signal-regulated kinase (ERK) pathway and cell proliferation in response to EGF.

UL138 HCMV expression is regulated by the transcription factor early growth response gene 1 (EGR1) downstream of EGFR-induced MEK / ERK signaling. We show that by targeting GAB1 and smoothes the MEK / ERK signaling, mir-US5-2 indirectly regulating the expression EGR1 and UL138, which implicates critical miRNA regulation latency.IMPORTANCE HCMV Human cytomegalovirus (HCMV) causes significant illness in immunocompromised individuals, including transplant patients. HCMV establishes latency in the hematopoietic stem cells in the bone marrow.

The mechanisms that regulate the latency and reactivation of viral replication is complex and not fully understood. HCMV-encoded miRNAs are small regulatory RNA that reduces expression of the protein. In this study, we found that HCMV miRNA miR-US5-2 targeting the epidermal growth factor receptor (EGFR) protein GAB1 adapter that directly affect downstream cellular signaling pathways activated by EGF. As a result, mir-US5-2 block EGF-mediated proliferation of human fibroblasts. early growth response gene 1 (EGR1) is a transcription factor activated by EGFR signaling that regulates the expression of HCMV UL138.

We show that miR-UL138 US5-2 regulates expression via downregulation GAB1-mediated signaling pathways that lead to the expression of EGR1. These data demonstrate that miR-US5-2, through downregulation of GAB1, can play an important role during the reactivation from latency by reducing the proliferation and expression of UL138.

 Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways
Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways

MKP-1 overproduction associated with chemoresistance in bladder cancer through the MAPK pathway

Mitogen-activated protein kinase phosphatase-1 (MKP-1) has been revealed to be expressed in bladder cancer, especially in non-muscle invasive bladder cancer. MKP-1 may also be associated with chemotherapy resistance. However, the underlying mechanism has not been elucidated. The current study examined the expression of MKP-1 by immunohistochemistry on surgical resection specimens obtained from patients with primary and recurrent bladder cancer.

The results showed that MKP-1 expression is increased in patients with recurrent. In addition, the 3D model of the line of human bladder cancer cells, RT112, was established to determine the role of MKP-1 in drug resistance. The results show that MKP-1 overproduction protected cells against bladder cancer cell death. Instead, MKP-1 knockdown lowered to sensitize cells to die.

FRS2 Antibody

3836-100 each
EUR 379.2

FRS2 Antibody

3836-30T each
EUR 175.2

FRS2 Antibody

39944-100ul 100ul
EUR 468

FRS2 Antibody

1-CSB-PA006727
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

FRS2 Antibody

E18-6466-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

FRS2 Antibody

E18-6466-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FRS2 Antibody

E18-0103-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

FRS2 Antibody

E18-0103-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FRS2 Antibody

GWB-1F0B26 0.1 ml Ask for price

FRS2 Antibody

E38PA6377 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 Antibody

E306692 100ug/200ul
EUR 275
Description: Available in various conjugation types.

FRS2 Antibody

E38PA5065 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 Antibody

AF0103 200ul
EUR 420

FRS2 Antibody

AF0103-100ul 100ul
EUR 280

FRS2 Antibody

AF0103-200ul 200ul
EUR 350

FRS2 Antibody

AF6466 200ul
EUR 420

FRS2 Antibody

AF6466-100ul 100ul
EUR 280

FRS2 Antibody

AF6466-200ul 200ul
EUR 350

FRS2 Antibody

1-CSB-PA002584
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/40000

FRS2 Antibody

1-CSB-PA009004GA01HU
  • Ask for price
  • Ask for price
  • 150ul
  • 50ul
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

FRS2 Antibody

1-CSB-PA009004LA01HU
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

FRS2 antibody

70R-17355 50 ul
EUR 289
Description: Rabbit polyclonal FRS2 antibody

FRS2 antibody

70R-32753 100 ug
EUR 294
Description: Rabbit polyclonal FRS2 antibody

FRS2 antibody

70R-12129 100 ug
EUR 343
Description: Rabbit polyclonal FRS2 antibody

FRS2 antibody

CAF50116-100ug 100ug
EUR 312

FRS2 Antibody

ABF6466 100 ug
EUR 525.6

FRS2 Antibody

ABF0103 100 ug
EUR 525.6

FRS2 Antibody

R36036-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Fibroblast growth factor receptor substrate 2

FRS2 Rabbit pAb

E2381932 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 Rabbit mAb

E2R26776 100ul
EUR 255
Description: Available in various conjugation types.

FRS2 Rabbit mAb

56195 100ul
EUR 339

FRS2 Rabbit mAb

A22711 1000μL
EUR 1557.4
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 150-400 of human Collagen III alpha 1/COL3A1 (P02461).

FRS2 Rabbit mAb

A22712 20μL
EUR 323.7
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 28-127aa of human SNX5.

FRS2 (Ab96) Antibody

33254 100ul
EUR 319

anti- FRS2 antibody

FNab03225 100µg
EUR 606.3
Description: Antibody raised against FRS2

FRS2 (pY436) Antibody

E38PA3944 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 (pY196) Antibody

E38PA5769 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 (pY436) Antibody

abx333006-100ul 100 ul
EUR 560.4

FRS2 (pY196) Antibody

abx215470-100ug 100 ug
EUR 526.8

FRS2 (pT436) Antibody

20-abx121481
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

FRS2 (pY436) Antibody

abx010808-100ug 100 ug
EUR 526.8

FRS2 (pY436) Antibody

abx333006-100g 100 µg Ask for price

FRS2 (pY436) Antibody

abx333006-20g 20 µg
EUR 412.5

FRS2 (pY436) Antibody

abx333006-50g 50 µg Ask for price

FRS2 antibody (Tyr436)

70R-34410 100 ug
EUR 294
Description: Rabbit polyclonal FRS2 antibody (Tyr436)

FRS2 cloning plasmid

CSB-CL009004HU-10ug 10ug
EUR 451.2
Description: A cloning plasmid for the FRS2 gene.

FRS2 Blocking Peptide

33R-10946 50 ug
EUR 145
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FRS2 antibody, catalog no. 70R-12129

FRS2 Blocking Peptide

3836BP-50 each
EUR 183.6

FRS2 Blocking Peptide

AF0103-BP 1mg
EUR 234

FRS2 Blocking Peptide

AF6466-BP 1mg
EUR 234

FRS2 Polyclonal Antibody

E96591 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 Polyclonal Antibody

E20-71791 100ug
EUR 225
Description: Available in various conjugation types.

FRS2 Polyclonal Antibody

E20-71792 100ug
EUR 225
Description: Available in various conjugation types.

Polyclonal FRS2 Antibody

APR16029G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FRS2 . This antibody is tested and proven to work in the following applications:

FRS2 Polyclonal Antibody

ABP53560-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y436

FRS2 Polyclonal Antibody

ABP53560-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y436

FRS2 Polyclonal Antibody

ABP53560-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y436

FRS2 Polyclonal Antibody

ABP51377-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y196

FRS2 Polyclonal Antibody

ABP51377-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y196

FRS2 Polyclonal Antibody

ABP51377-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y196

FRS2 Polyclonal Antibody

E44H02244 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

FRS2 Polyclonal Antibody

E44H04759 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rat FRS2 ELISA Kit

ERF0132 96Tests
EUR 625.2

Goat FRS2 ELISA Kit

EGTF0132 96Tests
EUR 625.2

Mouse FRS2 ELISA Kit

EMF0132 96Tests
EUR 625.2

Human FRS2 ELISA KIT

ELI-47347h 96 Tests
EUR 988.8

Mouse Frs2 ELISA KIT

ELI-38336m 96 Tests
EUR 1038

Sheep FRS2 ELISA Kit

ESF0132 96Tests
EUR 625.2

FRS2 ELISA KIT|Human

EF006838 96 Tests
EUR 826.8

Human FRS2 ELISA Kit

EHF0132 96Tests
EUR 625.2

Monkey FRS2 ELISA Kit

EMKF0132 96Tests
EUR 625.2

Rabbit FRS2 ELISA Kit

ERTF0132 96Tests
EUR 625.2

Canine FRS2 ELISA Kit

ECF0132 96Tests
EUR 625.2

Bovine FRS2 ELISA Kit

EBF0132 96Tests
EUR 625.2

FRS2 (Ab-196) Antibody

33254-100ul 100ul
EUR 302.4

FRS2 (Ab-196) Antibody

33254-50ul 50ul
EUR 224.4

FRS2 (Ab-196) Antibody

E033254 100μg/100μl
EUR 255
Description: Available in various conjugation types.

FRS2 (Ab-196) Antibody

E11-8202B 100μg
EUR 225
Description: Available in various conjugation types.

Porcine FRS2 ELISA Kit

EPF0132 96Tests
EUR 625.2

Chicken FRS2 ELISA Kit

ECKF0132 96Tests
EUR 625.2

FRS2 (Center) Rabbit pAb

E2614047 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 Rabbit PolymAb®

A23135 20μL
EUR 778.7
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 25-153 of human IL4 (NP_000580.1).

FRS2 (Ab-196) Antibody

CSB-PA208276- each
EUR 402
Description: A polyclonal antibody against FRS2 (Ab-196). Recognizes FRS2 (Ab-196) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

FRS2 (Ab-196) Antibody

CSB-PA208276-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against FRS2 (Ab-196). Recognizes FRS2 (Ab-196) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

FRS2 (Ab-196) Antibody

8B8202 50ug
EUR 368
Description: FRS2 (Ab-196) Antibody

Anserini FRS2 ELISA Kit

EAF0132 96Tests
EUR 625.2

Human FRS2 shRNA Plasmid

20-abx957376
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Mouse FRS2 shRNA Plasmid

20-abx983496
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Frs2 (GFP-tagged) - Mouse fibroblast growth factor receptor substrate 2 (Frs2)

MG208163 10 µg Ask for price

Frs2 (untagged) - Mouse fibroblast growth factor receptor substrate 2 (Frs2), (10ug)

MC217223 10 µg Ask for price

FRS2 (pY436) Blocking Peptide

20-abx162437
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

FRS2 Antibody, HRP conjugated

1-CSB-PA009004LB01HU
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

FRS2 (Phospho- Tyr196) Antibody

ABF8197 100 ug
EUR 525.6

Phospho- FRS2 (Tyr436) Antibody

ABF3466 100 ug
EUR 525.6

FRS2 Recombinant Protein (Rat)

RP201782 100 ug Ask for price

FRS2 Antibody, FITC conjugated

1-CSB-PA009004LC01HU
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OACD03618-1ML - FRS2 Antibody

OACD03618-1ML 1ml
EUR 669

OACD03619-1ML - FRS2 Antibody

OACD03619-1ML 1ml
EUR 729

OACD03620-1ML - FRS2 Antibody

OACD03620-1ML 1ml
EUR 649

FRS2 (Phospho-Tyr196) Antibody

12539-100ul 100ul
EUR 302.4

FRS2 (Phospho-Tyr196) Antibody

12539-50ul 50ul
EUR 224.4

FRS2 (Phospho-Tyr436) Antibody

11769 100ul
EUR 319

FRS2 (Phospho-Tyr436) Antibody

11769-100ul 100ul
EUR 302.4

FRS2 (Phospho-Tyr436) Antibody

11769-50ul 50ul
EUR 224.4

FRS2 (Phospho-Tyr436) Antibody

E011769 100μg/100μl
EUR 255
Description: Available in various conjugation types.

FRS2 (Phospho-Tyr436) Antibody

E11-8239A 100μg
EUR 225
Description: Available in various conjugation types.

FRS2 (Phospho-Tyr436) Antibody

8A8239 50ug
EUR 368
Description: FRS2 (Phospho-Tyr436) Antibody

FRS2 (Phospho-Tyr436) Antibody

20-abx012649
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

FRS2 Recombinant Protein (Mouse)

RP135275 100 ug Ask for price

FRS2 Recombinant Protein (Human)

RP012553 100 ug Ask for price

OACA10321-50UG - FRS2 Antibody

OACA10321-50UG 50ug
EUR 179

FRS2 (Phospho-Tyr436) Antibody

abx012649-100g 100 µg
EUR 237.5

FRS2 (Phospho-Tyr436) Antibody

abx012649-10g 10 µg
EUR 43.75

FRS2 (Phospho-Tyr436) Antibody

abx012649-200g 200 µg
EUR 312.5

FRS2 Rabbit Polyclonal Antibody

ES4559-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against FRS2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

FRS2 Rabbit Polyclonal Antibody

ES4559-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against FRS2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

FRS2 Rabbit Polyclonal Antibody

ES2376-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against FRS2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

FRS2 Rabbit Polyclonal Antibody

ES2376-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against FRS2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal FRS2 Antibody (Center)

APR16030G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FRS2 (Center). This antibody is tested and proven to work in the following applications:

FRS2 Antibody, Biotin conjugated

1-CSB-PA009004LD01HU
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Rabbit Polyclonal FRS2 Antibody

TA325484 100 µl Ask for price

Rabbit Polyclonal FRS2 Antibody

TA325485 100 µl Ask for price

OAGA02118-100UL - FRS2 Antibody

OAGA02118-100UL 100ul
EUR 369

OACD03618-100UL - FRS2 Antibody

OACD03618-100UL 100ul
EUR 199

OACD03619-100UL - FRS2 Antibody

OACD03619-100UL 100ul
EUR 209

OACD03620-100UL - FRS2 Antibody

OACD03620-100UL 100ul
EUR 199

OACA10321-100UG - FRS2 Antibody

OACA10321-100UG 100ug
EUR 319

FRS2 Rabbit Monoclonal Antibody

E10G22734 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

FRS2 Rabbit Polyclonal Antibody

E10G22955 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

ARP86887_P050 - FRS2 Antibody (ARP86887_P050)

ARP86887_P050 100ul
EUR 389

Frs2 (Myc-DDK-tagged) - Mouse fibroblast growth factor receptor substrate 2 (Frs2)

MR208163 10 µg Ask for price

Frs2 ORF Vector (Rat) (pORF)

ORF067262 1.0 ug DNA
EUR 607.2

Guinea Pig FRS2 ELISA Kit

EGF0132 96Tests
EUR 625.2

Frs2 (untagged ORF) - Rat fibroblast growth factor receptor substrate 2 (Frs2), (10 ug)

RN202736 10 µg Ask for price

Frs2 ORF Vector (Mouse) (pORF)

ORF045093 1.0 ug DNA
EUR 607.2

FRS2 ORF Vector (Human) (pORF)

ORF004185 1.0 ug DNA
EUR 114

FRS2 Cell-Based ELISA Kit

EKA50237-5x96T 5x96T
EUR 2122.78

FRS2 Cell-Based ELISA Kit

EKA50237-96T 96T
EUR 446.9

Human FRS2 knockout cell line

ABC-KH5735 1 vial Ask for price
Description: Human FRS2 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human FRS2 knockdown cell line

ABC-KD5735 1 vial Ask for price
Description: Human FRS2 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human FRS2 Protein Lysate 20ug

IHUFRS2PLLY20UG each
EUR 213
Description: Human FRS2 Protein Lysate 20ug

FRS2 ELISA Kit (Mouse) (OKEI00451)

OKEI00451 96 Wells
EUR 920.4
Description: Description of target: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 4.688 pg/mL

FRS2 ELISA Kit (Human) (OKEI00196)

OKEI00196 96 Wells
EUR 920.4
Description: Description of target: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 9.375 pg/mL

FRS2-α (phospho-Tyr196) rabbit pAb

13845 100ul
EUR 319

FRS2-α (phospho-Tyr196) rabbit pAb

E013845 100μg/100μl
EUR 255
Description: Available in various conjugation types.

FRS2-α (phospho-Tyr196) rabbit pAb

E28PP1345 100μl
EUR 255
Description: Available in various conjugation types.

FRS2-α (phospho-Tyr196) rabbit pAb

E44H14431 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

FRS2 (Ab-196) Conjugated Antibody

C33254 100ul
EUR 476.4

FRS2 (untagged)-Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 1

SC115938 10 µg Ask for price

FRS2 (untagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 3

SC336513 10 µg Ask for price

FRS2 (untagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 4

SC336514 10 µg Ask for price

FRS2 (untagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 5

SC336515 10 µg Ask for price

FRS2 (untagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 6

SC336516 10 µg Ask for price

FRS2 (untagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 7

SC336517 10 µg Ask for price

FRS2 (untagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 8

SC336518 10 µg Ask for price

FRS2 (untagged)-Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 2

SC311392 10 µg Ask for price

Mouse Monoclonal anti-human FRS2

hAP-0739 50ug
EUR 400

Mouse Monoclonal anti-human FRS2

hAP-1003 50ug
EUR 400

Sheep Polyclonal anti-human FRS2

hAP-5186 50ug
EUR 400

OCOA17978-20UG - FRS2 Protein Lysate

OCOA17978-20UG 20ug
EUR 169

OCOA15198-20UG - FRS2 Protein Lysate

OCOA15198-20UG 20ug
EUR 269

OCOA01811-20UG - FRS2 Protein Lysate

OCOA01811-20UG 20ug
EUR 169

FRS2 Over-expression Lysate Product

GWB-6E61E8 0.1 mg Ask for price

FRS2 (phospho Tyr436) Polyclonal Antibody

E20-60805 100ug
EUR 225
Description: Available in various conjugation types.

FRS2 (phospho Tyr436) Polyclonal Antibody

ABP50497-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of FRS2 phospho Tyr436) from Human, Mouse, Monkey. This FRS2 phospho Tyr436) antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the phosphorylation site of Y436

FRS2 (phospho Tyr436) Polyclonal Antibody

ABP50497-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of FRS2 phospho Tyr436) from Human, Mouse, Monkey. This FRS2 phospho Tyr436) antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the phosphorylation site of Y436

FRS2 (phospho Tyr436) Polyclonal Antibody

ABP50497-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of FRS2 phospho Tyr436) from Human, Mouse, Monkey. This FRS2 phospho Tyr436) antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the phosphorylation site of Y436

FRS2 (phospho Tyr436) Polyclonal Antibody

E44H01289 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

OPCD03306-10UG - FRS2 Recombinant Protein

OPCD03306-10UG 10ug
EUR 139

OPCD03306-50UG - FRS2 Recombinant Protein

OPCD03306-50UG 50ug
EUR 339

OPCD03307-10UG - FRS2 Recombinant Protein

OPCD03307-10UG 10ug
EUR 149

OPCD03307-50UG - FRS2 Recombinant Protein

OPCD03307-50UG 50ug
EUR 379

OPCD03308-10UG - FRS2 Recombinant Protein

OPCD03308-10UG 10ug
EUR 139

OPCD03308-50UG - FRS2 Recombinant Protein

OPCD03308-50UG 50ug
EUR 349

FRS2 (GFP-tagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 2

RG214628 10 µg Ask for price

FRS2 (GFP-tagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 1

RG205842 10 µg Ask for price

OPCD03306-200UG - FRS2 Recombinant Protein

OPCD03306-200UG 200ug
EUR 669

OPCD03307-200UG - FRS2 Recombinant Protein

OPCD03307-200UG 200ug
EUR 749

OPCD03308-200UG - FRS2 Recombinant Protein

OPCD03308-200UG 200ug
EUR 689

Frs2 (Myc-DDK-tagged ORF) - Rat fibroblast growth factor receptor substrate 2 (Frs2), (10 ug)

RR202736 10 µg Ask for price

Lenti ORF clone of Frs2 (mGFP-tagged) - Mouse fibroblast growth factor receptor substrate 2 (Frs2)

MR208163L4 10 µg Ask for price

FRS2 (myc-DDK-tagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 3

RC238619 10 µg Ask for price

FRS2 (myc-DDK-tagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 4

RC238620 10 µg Ask for price

FRS2 (myc-DDK-tagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 5

RC238621 10 µg Ask for price

FRS2 (myc-DDK-tagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 6

RC238622 10 µg Ask for price

FRS2 (myc-DDK-tagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 7

RC238623 10 µg Ask for price

FRS2 (myc-DDK-tagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 8

RC238624 10 µg Ask for price

FRS2 (Myc-DDK-tagged)-Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 1

RC205842 10 µg Ask for price

FRS2 (Myc-DDK-tagged)-Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 2

RC214628 10 µg Ask for price

Frs2 sgRNA CRISPR Lentivector set (Rat)

K6479601 3 x 1.0 ug
EUR 406.8

In addition, the application of MAPK inhibitors effectively increase the sensitivity of cells to pirarubicin RT112. In conclusion, the results of this study show that MKP-1 treatment resulted in bladder cancer cell chemoresistance through JNK, ERK and p38 pathways. MKP-1 can also serve as a potential therapeutic target for chemoresistance in patients with bladder cancer.