Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways

Regulation of the epidermal growth factor (EGF) receptor (EGFR) signaling is essential for the replication of human cytomegalovirus (HCMV) and the latency and reactivation in CD34 + hematopoietic progenitor cells. HCMV microRNAs (miRNAs) provide a means to modulate the signal is activated by EGF through targeting EGFR signaling pathway components. Here, we show that miR-US5-2 HCMV immediate critical downregulates EGFR GAB1 adapter proteins that mediate sustained activation and signals through phosphatidylinositol 3-kinase (PI3K) and MEK / extracellular signal-regulated kinase (ERK) pathway and cell proliferation in response to EGF.

UL138 HCMV expression is regulated by the transcription factor early growth response gene 1 (EGR1) downstream of EGFR-induced MEK / ERK signaling. We show that by targeting GAB1 and smoothes the MEK / ERK signaling, mir-US5-2 indirectly regulating the expression EGR1 and UL138, which implicates critical miRNA regulation latency.IMPORTANCE HCMV Human cytomegalovirus (HCMV) causes significant illness in immunocompromised individuals, including transplant patients. HCMV establishes latency in the hematopoietic stem cells in the bone marrow.

The mechanisms that regulate the latency and reactivation of viral replication is complex and not fully understood. HCMV-encoded miRNAs are small regulatory RNA that reduces expression of the protein. In this study, we found that HCMV miRNA miR-US5-2 targeting the epidermal growth factor receptor (EGFR) protein GAB1 adapter that directly affect downstream cellular signaling pathways activated by EGF. As a result, mir-US5-2 block EGF-mediated proliferation of human fibroblasts. early growth response gene 1 (EGR1) is a transcription factor activated by EGFR signaling that regulates the expression of HCMV UL138.

We show that miR-UL138 US5-2 regulates expression via downregulation GAB1-mediated signaling pathways that lead to the expression of EGR1. These data demonstrate that miR-US5-2, through downregulation of GAB1, can play an important role during the reactivation from latency by reducing the proliferation and expression of UL138.

 Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways
Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways

MKP-1 overproduction associated with chemoresistance in bladder cancer through the MAPK pathway

Mitogen-activated protein kinase phosphatase-1 (MKP-1) has been revealed to be expressed in bladder cancer, especially in non-muscle invasive bladder cancer. MKP-1 may also be associated with chemotherapy resistance. However, the underlying mechanism has not been elucidated. The current study examined the expression of MKP-1 by immunohistochemistry on surgical resection specimens obtained from patients with primary and recurrent bladder cancer.

The results showed that MKP-1 expression is increased in patients with recurrent. In addition, the 3D model of the line of human bladder cancer cells, RT112, was established to determine the role of MKP-1 in drug resistance. The results show that MKP-1 overproduction protected cells against bladder cancer cell death. Instead, MKP-1 knockdown lowered to sensitize cells to die.

FRS2 Antibody

3836-100 each
EUR 379.2

FRS2 Antibody

3836-30T each
EUR 175.2

FRS2 Antibody

39944-100ul 100ul
EUR 468

FRS2 Antibody

E18-0103-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

FRS2 Antibody

E18-0103-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FRS2 Antibody

E18-6466-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

FRS2 Antibody

E18-6466-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FRS2 Antibody

E38PA5065 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 Antibody

E38PA6377 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 Antibody

E306692 100ug/200ul
EUR 275
Description: Available in various conjugation types.

FRS2 antibody

CAF50116-100ug 100ug
EUR 312

FRS2 antibody

70R-17355 50 ul
EUR 289
Description: Rabbit polyclonal FRS2 antibody

FRS2 antibody

70R-12129 100 ug
EUR 343
Description: Rabbit polyclonal FRS2 antibody

FRS2 antibody

70R-32753 100 ug
EUR 294
Description: Rabbit polyclonal FRS2 antibody

FRS2 Antibody

AF0103 200ul
EUR 420

FRS2 Antibody

AF0103-100ul 100ul
EUR 280

FRS2 Antibody

AF0103-200ul 200ul
EUR 350

FRS2 Antibody

AF6466 200ul
EUR 420

FRS2 Antibody

AF6466-100ul 100ul
EUR 280

FRS2 Antibody

AF6466-200ul 200ul
EUR 350

FRS2 Antibody

1-CSB-PA009004GA01HU
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  • 150ul
  • 50ul
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

FRS2 Antibody

1-CSB-PA009004LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

FRS2 Antibody

1-CSB-PA006727
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  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

FRS2 Antibody

1-CSB-PA002584
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  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/40000

FRS2 Antibody

ABF0103 100ug
EUR 325

FRS2 Antibody

ABF6466 100ug
EUR 325

FRS2 Antibody

GWB-1F0B26 0.1 ml Ask for price

FRS2 Antibody

R36036-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Fibroblast growth factor receptor substrate 2

FRS2 Antibody

MBS7048201-005mg 0.05mg
EUR 190

FRS2 Antibody

MBS7048201-01mg 0.1mg
EUR 270

FRS2 Antibody

MBS7048201-5x01mg 5x0.1mg
EUR 1205

FRS2 Antibody

MBS7122619-005mg 0.05mg
EUR 150

FRS2 Antibody

MBS7122619-01mg 0.1mg
EUR 190

FRS2 Antibody

MBS7122619-5x01mg 5x0.1mg
EUR 845

FRS2 Antibody

MBS7117902-005mg 0.05mg
EUR 150

FRS2 Antibody

MBS7117902-01mg 0.1mg
EUR 190

FRS2 Antibody

MBS7117902-5x01mg 5x0.1mg
EUR 845

FRS2 Antibody

MBS9412895-01mL 0.1mL
EUR 420

FRS2 Antibody

MBS9412895-5x01mL 5x0.1mL
EUR 1740

FRS2 Antibody

MBS859879-01mg 0.1mg
EUR 345

FRS2 Antibody

MBS859879-01mLAF405L 0.1mL(AF405L)
EUR 565

FRS2 Antibody

MBS859879-01mLAF405S 0.1mL(AF405S)
EUR 565

FRS2 Antibody

MBS859879-01mLAF610 0.1mL(AF610)
EUR 565

FRS2 Antibody

MBS859879-01mLAF635 0.1mL(AF635)
EUR 565

FRS2 Antibody

MBS8584064-01mL 0.1mL
EUR 305

FRS2 Antibody

MBS8584064-01mLAF405L 0.1mL(AF405L)
EUR 465

FRS2 Antibody

MBS8584064-01mLAF405S 0.1mL(AF405S)
EUR 465

FRS2 Antibody

MBS8584064-01mLAF610 0.1mL(AF610)
EUR 465

FRS2 Antibody

MBS8584064-01mLAF635 0.1mL(AF635)
EUR 465

FRS2 Antibody

MBS8582909-01mL 0.1mL
EUR 305

FRS2 Antibody

MBS8582909-01mLAF405L 0.1mL(AF405L)
EUR 465

FRS2 Antibody

MBS8582909-01mLAF405S 0.1mL(AF405S)
EUR 465

FRS2 Antibody

MBS8582909-01mLAF610 0.1mL(AF610)
EUR 465

FRS2 Antibody

MBS8582909-01mLAF635 0.1mL(AF635)
EUR 465

FRS2 Antibody

MBS8512468-005mg 0.05mg
EUR 235

FRS2 Antibody

MBS8512468-01mg 0.1mg
EUR 305

FRS2 Antibody

MBS8512468-01mLAF405M 0.1mL(AF405M)
EUR 465

FRS2 Antibody

MBS8512468-01mLAF546 0.1mL(AF546)
EUR 465

FRS2 Antibody

MBS8512468-01mLAF750 0.1mL(AF750)
EUR 465

FRS2 Antibody

MBS8510604-005mg 0.05mg
EUR 235

FRS2 Antibody

MBS8510604-01mg 0.1mg
EUR 305

FRS2 Antibody

MBS8510604-01mLAF405M 0.1mL(AF405M)
EUR 465

FRS2 Antibody

MBS8510604-01mLAF546 0.1mL(AF546)
EUR 465

FRS2 Antibody

MBS8510604-01mLAF750 0.1mL(AF750)
EUR 465

FRS2 Antibody

MBS5311505-01mg 0.1mg
EUR 470

FRS2 Antibody

MBS5311505-5x01mg 5x0.1mg
EUR 2080

FRS2 Antibody

MBS9602011-01mL 0.1mL
EUR 260

FRS2 Antibody

MBS9602011-02mL 0.2mL
EUR 305

FRS2 Antibody

MBS9602011-5x02mL 5x0.2mL
EUR 1220

FRS2 Antibody

MBS9504405-005mL 0.05mL
EUR 285

FRS2 Antibody

MBS9504405-01mL 0.1mL
EUR 385

FRS2 Antibody

MBS9504405-5x01mL 5x0.1mL
EUR 1590

FRS2 Antibody

MBS9504423-005mL 0.05mL
EUR 285

FRS2 Antibody

MBS9504423-01mL 0.1mL
EUR 385

FRS2 Antibody

MBS9504423-5x01mL 5x0.1mL
EUR 1590

FRS2 Antibody

MBS9600047-01mL 0.1mL
EUR 260

FRS2 Antibody

MBS9600047-02mL 0.2mL
EUR 305

FRS2 Antibody

MBS9600047-5x02mL 5x0.2mL
EUR 1220

FRS2 Antibody

B8202-100ul 100μl
EUR 217
Description: FRS2 Rabbit Polyclonal Antibody

FRS2 Antibody

B8202-50ul 50μl
EUR 143.5
Description: FRS2 Rabbit Polyclonal Antibody

FRS2 Antibody

B8239-100ul 100μl
EUR 217
Description: FRS2 Rabbit Polyclonal Antibody

FRS2 Antibody

B8239-50ul 50μl
EUR 143.5
Description: FRS2 Rabbit Polyclonal Antibody

FRS2 Rabbit pAb

E2381932 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 Rabbit mAb

E2R26776 100ul
EUR 255
Description: Available in various conjugation types.

FRS2 Rabbit mAb

56195 100ul
EUR 339

FRS2 Rabbit mAb

A22711 1000μL
EUR 1557.4
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 150-400 of human Collagen III alpha 1/COL3A1 (P02461).

FRS2 Rabbit mAb

A22712 20μL
EUR 323.7
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 28-127aa of human SNX5.

FRS2 cDNA Clone

MBS1278477-001mgPlasmid02mLGlycerolStock 0.01mgPlasmid+0.2mLGlycerol-Stock
EUR 330

FRS2 cDNA Clone

MBS1278477-5x001mgPlasmid5x02mLGlycerolStock 5x0.01mgPlasmid+5x0.2mLGlycerol-Stock
EUR 1430

FRS2 Rabbit pAb

MBS8543396-01mL 0.1mL
EUR 305

FRS2 Rabbit pAb

MBS8543396-01mLAF405L 0.1mL(AF405L)
EUR 565

FRS2 Rabbit pAb

MBS8543396-01mLAF405S 0.1mL(AF405S)
EUR 565

FRS2 Rabbit pAb

MBS8543396-01mLAF610 0.1mL(AF610)
EUR 565

FRS2 Rabbit pAb

MBS8543396-01mLAF635 0.1mL(AF635)
EUR 565

FRS2 Rabbit mAb

MBS4753274-01mL 0.1mL
EUR 450

FRS2 Rabbit mAb

MBS4753274-5x01mL 5x0.1mL
EUR 1540

FRS2 Rabbit pAb

A6591 100μL
EUR 70.85

FRS2 siRNA (Mouse)

MBS8229882-15nmol 15nmol
EUR 405

FRS2 siRNA (Mouse)

MBS8229882-30nmol 30nmol
EUR 565

FRS2 siRNA (Mouse)

MBS8229882-5x30nmol 5x30nmol
EUR 2450

FRS2 siRNA (Human)

MBS8213984-15nmol 15nmol
EUR 405

FRS2 siRNA (Human)

MBS8213984-30nmol 30nmol
EUR 565

FRS2 siRNA (Human)

MBS8213984-5x30nmol 5x30nmol
EUR 2450

FRS2 (Ab96) Antibody

33254 100ul
EUR 319

anti- FRS2 antibody

FNab03225 100µg
EUR 606.3
Description: Antibody raised against FRS2

FRS2 (pT436) Antibody

20-abx121481
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  • 100 ul
  • 200 ul
  • 30 ul

FRS2 (pY436) Antibody

abx010808-100ug 100 ug
EUR 526.8

FRS2 (pY196) Antibody

abx215470-100ug 100 ug
EUR 526.8

FRS2 (pY436) Antibody

abx333006-100ul 100 ul
EUR 560.4

FRS2 (pY196) Antibody

E38PA5769 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 (pY436) Antibody

E38PA3944 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 (pY436) Antibody

abx333006-100g 100 µg Ask for price

FRS2 (pY436) Antibody

abx333006-20g 20 µg
EUR 412.5

FRS2 (pY436) Antibody

abx333006-50g 50 µg Ask for price

FRS2 (pY196) Antibody

MBS8583459-01mL 0.1mL
EUR 305

FRS2 (pY196) Antibody

MBS8583459-01mLAF405L 0.1mL(AF405L)
EUR 465

FRS2 (pY196) Antibody

MBS8583459-01mLAF405S 0.1mL(AF405S)
EUR 465

FRS2 (pY196) Antibody

MBS8583459-01mLAF610 0.1mL(AF610)
EUR 465

FRS2 (pY196) Antibody

MBS8583459-01mLAF635 0.1mL(AF635)
EUR 465

FRS2 (pY436) Antibody

MBS8582239-01mL 0.1mL
EUR 305

FRS2 (pY436) Antibody

MBS8582239-01mLAF405L 0.1mL(AF405L)
EUR 465

FRS2 (pY436) Antibody

MBS8582239-01mLAF405S 0.1mL(AF405S)
EUR 465

FRS2 (pY436) Antibody

MBS8582239-01mLAF610 0.1mL(AF610)
EUR 465

FRS2 (pY436) Antibody

MBS8582239-01mLAF635 0.1mL(AF635)
EUR 465

FRS2 antibody (Tyr436)

70R-34410 100 ug
EUR 294
Description: Rabbit polyclonal FRS2 antibody (Tyr436)

FRS2 cloning plasmid

CSB-CL009004HU-10ug 10ug
EUR 451.2
Description: A cloning plasmid for the FRS2 gene.

FRS2 Antibody (Center)

MBS9209180-008mL 0.08mL
EUR 210

FRS2 Antibody (Center)

MBS9209180-04mL 0.4mL
EUR 430

FRS2 Antibody (Center)

MBS9209180-5x04mL 5x0.4mL
EUR 1910

FRS2 Blocking Peptide

33R-10946 50 ug
EUR 145
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FRS2 antibody, catalog no. 70R-12129

FRS2 Blocking Peptide

3836BP-50 each
EUR 183.6

FRS2 Blocking Peptide

AF0103-BP 1mg
EUR 234

FRS2 Blocking Peptide

AF6466-BP 1mg
EUR 234

FRS2 Blocking Peptide

MBS8244375-1mg 1mg
EUR 190

FRS2 Blocking Peptide

MBS8244375-5mg 5mg
EUR 345

FRS2 Blocking Peptide

MBS8244375-5x5mg 5x5mg
EUR 1465

FRS2 Blocking Peptide

MBS9614599-1mg 1mg
EUR 380

FRS2 Blocking Peptide

MBS9614599-5x1mg 5x1mg
EUR 1650

FRS2 Blocking Peptide

MBS9617570-1mg 1mg
EUR 380

FRS2 Blocking Peptide

MBS9617570-5x1mg 5x1mg
EUR 1650

Recombinant Human FRS2

MBS7613781-005mg 0.05mg
EUR 405

Recombinant Human FRS2

MBS7613781-02mg 0.2mg
EUR 760

Recombinant Human FRS2

MBS7613781-1mg 1mg
EUR 2175

Recombinant Human FRS2

MBS7613781-5x1mg 5x1mg
EUR 8410

FRS2 Immunizing Peptide

MBS428238-01mg 0.1mg
EUR 225

FRS2 Polyclonal Antibody

ABP51377-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y196

FRS2 Polyclonal Antibody

ABP51377-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y196

FRS2 Polyclonal Antibody

ABP51377-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y196

FRS2 Polyclonal Antibody

ABP53560-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y436

FRS2 Polyclonal Antibody

ABP53560-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y436

FRS2 Polyclonal Antibody

ABP53560-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y436

FRS2 Polyclonal Antibody

E96591 100ul
EUR 225
Description: Available in various conjugation types.

FRS2 Polyclonal Antibody

E20-71791 100ug
EUR 225
Description: Available in various conjugation types.

FRS2 Polyclonal Antibody

E20-71792 100ug
EUR 225
Description: Available in various conjugation types.

Polyclonal FRS2 Antibody

APR16029G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FRS2 . This antibody is tested and proven to work in the following applications:

FRS2 Polyclonal Antibody

E44H04759 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

FRS2 Polyclonal Antibody

E44H02244 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

FRS2 Polyclonal Antibody

BT-AP03374-100ul 100ul Ask for price
Description: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

FRS2 Polyclonal Antibody

BT-AP03374-20ul 20ul Ask for price
Description: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

FRS2 Polyclonal Antibody

BT-AP03374-50ul 50ul Ask for price
Description: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

FRS2 Polyclonal Antibody

BT-AP03375-100ul 100ul Ask for price
Description: Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) has an alternative name as SNT-1, it is an adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. FRS2 is a 508 amino-acid protein, which is phosphorylated on tyrosine residues. The molecular weight of non-phosphorylated FRS2 is 57-68 kDa, but phosphorylated FRS2 is 80-90 kDa. Phosphorylation of FRS2 is associated with activation of a number of MAP kinases. Allele-specific regulation of FGFR2 mRNA expression with a mildly increased breast cancer risk has been reported.

FRS2 Polyclonal Antibody

BT-AP03375-20ul 20ul Ask for price
Description: Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) has an alternative name as SNT-1, it is an adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. FRS2 is a 508 amino-acid protein, which is phosphorylated on tyrosine residues. The molecular weight of non-phosphorylated FRS2 is 57-68 kDa, but phosphorylated FRS2 is 80-90 kDa. Phosphorylation of FRS2 is associated with activation of a number of MAP kinases. Allele-specific regulation of FGFR2 mRNA expression with a mildly increased breast cancer risk has been reported.

FRS2 Polyclonal Antibody

BT-AP03375-50ul 50ul Ask for price
Description: Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) has an alternative name as SNT-1, it is an adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. FRS2 is a 508 amino-acid protein, which is phosphorylated on tyrosine residues. The molecular weight of non-phosphorylated FRS2 is 57-68 kDa, but phosphorylated FRS2 is 80-90 kDa. Phosphorylation of FRS2 is associated with activation of a number of MAP kinases. Allele-specific regulation of FGFR2 mRNA expression with a mildly increased breast cancer risk has been reported.

FRS2 Polyclonal Antibody

MBS9243706-01mL 0.1mL
EUR 415

FRS2 Polyclonal Antibody

MBS9243706-5x01mL 5x0.1mL
EUR 1841

FRS2 Polyclonal Antibody

MBS9243707-01mL 0.1mL
EUR 415

FRS2 Polyclonal Antibody

MBS9243707-5x01mL 5x0.1mL
EUR 1841

FRS2 Polyclonal Antibody

MBS8572991-01mL 0.1mL
EUR 305

FRS2 Polyclonal Antibody

MBS8572991-01mLAF405L 0.1mL(AF405L)
EUR 565

FRS2 Polyclonal Antibody

MBS8572991-01mLAF405S 0.1mL(AF405S)
EUR 565

FRS2 Polyclonal Antibody

MBS8572991-01mLAF610 0.1mL(AF610)
EUR 565

FRS2 Polyclonal Antibody

MBS8572991-01mLAF635 0.1mL(AF635)
EUR 565

FRS2 Polyclonal Antibody

MBS8522772-01mg 0.1mg
EUR 305

FRS2 Polyclonal Antibody

MBS8522772-01mLAF405L 0.1mL(AF405L)
EUR 465

FRS2 Polyclonal Antibody

MBS8522772-01mLAF405S 0.1mL(AF405S)
EUR 465

FRS2 Polyclonal Antibody

MBS8522772-01mLAF610 0.1mL(AF610)
EUR 465

FRS2 Polyclonal Antibody

MBS8522772-01mLAF635 0.1mL(AF635)
EUR 465

FRS2 Polyclonal Antibody

MBS8522773-01mg 0.1mg
EUR 305

FRS2 Polyclonal Antibody

MBS8522773-01mLAF405L 0.1mL(AF405L)
EUR 465

FRS2 Polyclonal Antibody

MBS8522773-01mLAF405S 0.1mL(AF405S)
EUR 465

FRS2 Polyclonal Antibody

MBS8522773-01mLAF610 0.1mL(AF610)
EUR 465

FRS2 Polyclonal Antibody

MBS8522773-01mLAF635 0.1mL(AF635)
EUR 465

FRS2 Polyclonal Antibody

MBS2536042-002mL 0.02mL
EUR 140

FRS2 Polyclonal Antibody

MBS2536042-006mL 0.06mL
EUR 180

FRS2 Polyclonal Antibody

MBS2536042-012mL 0.12mL
EUR 260

FRS2 Polyclonal Antibody

MBS2536042-02mL 0.2mL
EUR 405

FRS2 Polyclonal Antibody

MBS2536929-002mL 0.02mL
EUR 140

FRS2 Polyclonal Antibody

MBS2536929-006mL 0.06mL
EUR 180

FRS2 Polyclonal Antibody

MBS2536929-012mL 0.12mL
EUR 260

FRS2 Polyclonal Antibody

MBS2536929-02mL 0.2mL
EUR 405

In addition, the application of MAPK inhibitors effectively increase the sensitivity of cells to pirarubicin RT112. In conclusion, the results of this study show that MKP-1 treatment resulted in bladder cancer cell chemoresistance through JNK, ERK and p38 pathways. MKP-1 can also serve as a potential therapeutic target for chemoresistance in patients with bladder cancer.