Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways

Regulation of the epidermal growth factor (EGF) receptor (EGFR) signaling is essential for the replication of human cytomegalovirus (HCMV) and the latency and reactivation in CD34 + hematopoietic progenitor cells. HCMV microRNAs (miRNAs) provide a means to modulate the signal is activated by EGF through targeting EGFR signaling pathway components. Here, we show that miR-US5-2 HCMV immediate critical downregulates EGFR GAB1 adapter proteins that mediate sustained activation and signals through phosphatidylinositol 3-kinase (PI3K) and MEK / extracellular signal-regulated kinase (ERK) pathway and cell proliferation in response to EGF.

UL138 HCMV expression is regulated by the transcription factor early growth response gene 1 (EGR1) downstream of EGFR-induced MEK / ERK signaling. We show that by targeting GAB1 and smoothes the MEK / ERK signaling, mir-US5-2 indirectly regulating the expression EGR1 and UL138, which implicates critical miRNA regulation latency.IMPORTANCE HCMV Human cytomegalovirus (HCMV) causes significant illness in immunocompromised individuals, including transplant patients. HCMV establishes latency in the hematopoietic stem cells in the bone marrow.

The mechanisms that regulate the latency and reactivation of viral replication is complex and not fully understood. HCMV-encoded miRNAs are small regulatory RNA that reduces expression of the protein. In this study, we found that HCMV miRNA miR-US5-2 targeting the epidermal growth factor receptor (EGFR) protein GAB1 adapter that directly affect downstream cellular signaling pathways activated by EGF. As a result, mir-US5-2 block EGF-mediated proliferation of human fibroblasts. early growth response gene 1 (EGR1) is a transcription factor activated by EGFR signaling that regulates the expression of HCMV UL138.

We show that miR-UL138 US5-2 regulates expression via downregulation GAB1-mediated signaling pathways that lead to the expression of EGR1. These data demonstrate that miR-US5-2, through downregulation of GAB1, can play an important role during the reactivation from latency by reducing the proliferation and expression of UL138.

 Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways
Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways

MKP-1 overproduction associated with chemoresistance in bladder cancer through the MAPK pathway

Mitogen-activated protein kinase phosphatase-1 (MKP-1) has been revealed to be expressed in bladder cancer, especially in non-muscle invasive bladder cancer. MKP-1 may also be associated with chemotherapy resistance. However, the underlying mechanism has not been elucidated. The current study examined the expression of MKP-1 by immunohistochemistry on surgical resection specimens obtained from patients with primary and recurrent bladder cancer.

The results showed that MKP-1 expression is increased in patients with recurrent. In addition, the 3D model of the line of human bladder cancer cells, RT112, was established to determine the role of MKP-1 in drug resistance. The results show that MKP-1 overproduction protected cells against bladder cancer cell death. Instead, MKP-1 knockdown lowered to sensitize cells to die.

FRS2 Antibody

AF0103 200ul
EUR 420

FRS2 siRNA

20-abx917231
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FRS2 siRNA

20-abx917232
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FRS2 Antibody

1-CSB-PA006727
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

FRS2 antibody

70R-32753 100 ug
EUR 392.4
Description: Rabbit polyclonal FRS2 antibody

FRS2 Antibody

39944-100ul 100ul
EUR 468

FRS2 Peptide

43-630P 0.1 mg
EUR 405.6

FRS2 antibody

70R-12129 100 ug
EUR 483.6
Description: Rabbit polyclonal FRS2 antibody

FRS2 antibody

70R-17355 50 ul
EUR 522
Description: Rabbit polyclonal FRS2 antibody

FRS2 Antibody

3836-100
EUR 379.2

FRS2 Antibody

3836-30T
EUR 175.2

FRS2 Antibody

ABF0103 100 ug
EUR 525.6

FRS2 Antibody

ABF6466 100 ug
EUR 525.6

anti-FRS2

YF-PA25676 50 ul
EUR 400.8
Description: Mouse polyclonal to FRS2

anti-FRS2

YF-PA17237 50 ug
EUR 435.6
Description: Mouse polyclonal to FRS2

anti-FRS2

YF-PA17238 100 ul
EUR 483.6
Description: Rabbit polyclonal to FRS2

FRS2 Antibody

R36036-100UG 100 ug
EUR 399

FRS2 Polyclonal Antibody

ABP51377-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y196

FRS2 Polyclonal Antibody

ABP51377-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y196

FRS2 Polyclonal Antibody

ABP51377-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y196

FRS2 Polyclonal Antibody

ABP53560-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y436

FRS2 Polyclonal Antibody

ABP53560-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y436

FRS2 Polyclonal Antibody

ABP53560-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of FRS2 from Human, Mouse. This FRS2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y436

FRS2 Blocking Peptide

AF6466-BP 1mg
EUR 234

FRS2 Blocking Peptide

AF0103-BP 1mg
EUR 234

FRS2 cloning plasmid

CSB-CL009004HU-10ug 10ug
EUR 451.2
Description: A cloning plasmid for the FRS2 gene.

anti- FRS2 antibody

FNab03225 100µg
EUR 606.3
Description: Antibody raised against FRS2

FRS2 Polyclonal Antibody

ES2376-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against FRS2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

FRS2 Polyclonal Antibody

ES2376-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against FRS2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

FRS2 Polyclonal Antibody

ES4559-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against FRS2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

FRS2 Polyclonal Antibody

ES4559-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against FRS2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

FRS2 antibody (Tyr436)

70R-34410 100 ug
EUR 392.4
Description: Rabbit polyclonal FRS2 antibody (Tyr436)

FRS2 Blocking Peptide

3836BP-50
EUR 183.6

FRS2 Blocking Peptide

33R-10946 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FRS2 antibody, catalog no. 70R-12129

FRS2 (pT436) Antibody

20-abx121481
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

FRS2 (pY436) Antibody

abx010808-100ug 100 ug
EUR 526.8

FRS2 (pY436) Antibody

abx333006-100ul 100 ul
EUR 560.4

FRS2 (pY196) Antibody

abx215470-100ug 100 ug
EUR 526.8

Polyclonal FRS2 Antibody

APR16029G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FRS2 . This antibody is tested and proven to work in the following applications:

Anti-FRS2 antibody

PAab03225 100 ug
EUR 426

Anti-FRS2 antibody

STJ73094 100 µg
EUR 430.8

Anti-FRS2 antibody

STJ93156 200 µl
EUR 236.4
Description: Rabbit polyclonal to FRS2.

Anti-FRS2 antibody

STJ93157 200 µl
EUR 236.4
Description: Rabbit polyclonal to FRS2.

FRS2 (Ab-196) Antibody

CSB-PA208276-
EUR 402
Description: A polyclonal antibody against FRS2 (Ab-196). Recognizes FRS2 (Ab-196) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

FRS2 (Ab-196) Antibody

CSB-PA208276-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against FRS2 (Ab-196). Recognizes FRS2 (Ab-196) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

Phospho-FRS2 (Y436) Antibody

1-CSB-PA000714
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-FRS2 (Y436). Recognizes Phospho-FRS2 (Y436) from Human, Mouse, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000

FRS2 Antibody, HRP conjugated

1-CSB-PA009004LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

FRS2 Antibody, FITC conjugated

1-CSB-PA009004LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

FRS2 Antibody, Biotin conjugated

1-CSB-PA009004LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FRS2. Recognizes FRS2 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Phospho-FRS2 (Tyr196) Antibody

AF8197 200ul
EUR 540

Mouse FRS2 shRNA Plasmid

20-abx983496
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Phospho-FRS2 (Tyr436) Antibody

AF3466 200ul
EUR 420

Human FRS2 shRNA Plasmid

20-abx957376
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Phospho-FRS2 (Tyr436) Antibody

CSB-PA946917-
EUR 402
Description: A polyclonal antibody against Phospho-FRS2 (Tyr436). Recognizes Phospho-FRS2 (Tyr436) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-FRS2 (Tyr436) Antibody

CSB-PA946917-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-FRS2 (Tyr436). Recognizes Phospho-FRS2 (Tyr436) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Mouse FRS2 ELISA Kit

EMF0132 96Tests
EUR 625.2

Sheep FRS2 ELISA Kit

ESF0132 96Tests
EUR 625.2

Human FRS2 ELISA Kit

EHF0132 96Tests
EUR 625.2

Monkey FRS2 ELISA Kit

EMKF0132 96Tests
EUR 625.2

Rat FRS2 ELISA Kit

ERF0132 96Tests
EUR 625.2

Rabbit FRS2 ELISA Kit

ERTF0132 96Tests
EUR 625.2

Porcine FRS2 ELISA Kit

EPF0132 96Tests
EUR 625.2

FRS2 (Ab-196) Antibody

33254-100ul 100ul
EUR 302.4

FRS2 (Ab-196) Antibody

33254-50ul 50ul
EUR 224.4

FRS2 (Phospho-Tyr196) Antibody

12539-100ul 100ul
EUR 302.4

FRS2 (Phospho-Tyr196) Antibody

12539-50ul 50ul
EUR 224.4

FRS2 (Phospho-Tyr436) Antibody

11769-100ul 100ul
EUR 302.4

FRS2 (Phospho-Tyr436) Antibody

11769-50ul 50ul
EUR 224.4

FRS2 (pY436) Blocking Peptide

20-abx162437
  • EUR 376.80
  • EUR 610.80
  • 1 mg
  • 5 mg

FRS2 (Phospho-Tyr436) Antibody

20-abx012649
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

FRS2 (Phospho- Tyr196) Antibody

ABF8197 100 ug
EUR 525.6

Phospho- FRS2 (Tyr436) Antibody

ABF3466 100 ug
EUR 525.6

Polyclonal FRS2 Antibody (Center)

APR16030G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FRS2 (Center). This antibody is tested and proven to work in the following applications:

Anti-FRS2 Monoclonal Antibody

M02798 100ug
EUR 476.4
Description: Rabbit Monoclonal FRS2 Antibody. Validated in IP, WB and tested in Human.

Goat FRS2 ELISA Kit

EGTF0132 96Tests
EUR 625.2

Human FRS2 ELISA KIT

ELI-47347h 96 Tests
EUR 988.8

Mouse Frs2 ELISA KIT

ELI-38336m 96 Tests
EUR 1038

Bovine FRS2 ELISA Kit

EBF0132 96Tests
EUR 625.2

Canine FRS2 ELISA Kit

ECF0132 96Tests
EUR 625.2

Chicken FRS2 ELISA Kit

ECKF0132 96Tests
EUR 625.2

FRS2 ELISA KIT|Human

EF006838 96 Tests
EUR 826.8

Anserini FRS2 ELISA Kit

EAF0132 96Tests
EUR 625.2

FRS2 Recombinant Protein (Rat)

RP201782 100 ug Ask for price

Anti-FRS2 (1F7-1D6)

YF-MA17494 100 ug
EUR 435.6
Description: Mouse monoclonal to FRS2

FRS2 Recombinant Protein (Mouse)

RP135275 100 ug Ask for price

FRS2 Recombinant Protein (Human)

RP012553 100 ug Ask for price

FRS2 (phospho Tyr436) Polyclonal Antibody

ABP50497-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of FRS2 phospho Tyr436) from Human, Mouse, Monkey. This FRS2 phospho Tyr436) antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the phosphorylation site of Y436

FRS2 (phospho Tyr436) Polyclonal Antibody

ABP50497-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of FRS2 phospho Tyr436) from Human, Mouse, Monkey. This FRS2 phospho Tyr436) antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the phosphorylation site of Y436

FRS2 (phospho Tyr436) Polyclonal Antibody

ABP50497-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of FRS2 phospho Tyr436) from Human, Mouse, Monkey. This FRS2 phospho Tyr436) antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FRS2 around the phosphorylation site of Y436

FRS2 (Ab-196) Conjugated Antibody

C33254 100ul
EUR 476.4

Phospho-FRS2 (Tyr196) Blocking Peptide

AF8197-BP 1mg
EUR 234

Phospho-FRS2 (Tyr436) Blocking Peptide

AF3466-BP 1mg
EUR 234

FRS2 (phospho Tyr436) Polyclonal Antibody

ES1496-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against FRS2 (phospho Tyr436) from Human/Mouse/Monkey. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

FRS2 (phospho Tyr436) Polyclonal Antibody

ES1496-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against FRS2 (phospho Tyr436) from Human/Mouse/Monkey. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Frs2 ORF Vector (Rat) (pORF)

ORF067262 1.0 ug DNA
EUR 607.2

FRS2 ELISA Kit (Human) (OKEI00196)

OKEI00196 96 Wells
EUR 920.4
Description: Description of target: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 9.375 pg/mL

FRS2 ELISA Kit (Mouse) (OKEI00451)

OKEI00451 96 Wells
EUR 920.4
Description: Description of target: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 4.688 pg/mL

FRS2 ORF Vector (Human) (pORF)

ORF004185 1.0 ug DNA
EUR 114

Frs2 ORF Vector (Mouse) (pORF)

ORF045093 1.0 ug DNA
EUR 607.2

Guinea Pig FRS2 ELISA Kit

EGF0132 96Tests
EUR 625.2

Anti-Phospho-FRS2 (Y436) antibody

STJ90965 200 µl
EUR 236.4
Description: Rabbit polyclonal to Phospho-FRS2 (Y436).

FRS2 (Phospho-Tyr436) Polyclonal Conjugated Antibody

C11769 100ul
EUR 476.4

FRS2 (Phospho-Tyr196) Polyclonal Conjugated Antibody

C12539 100ul
EUR 476.4

FRS2 Colorimetric Cell-Based ELISA Kit

EKC1226 100ul
EUR 686.4

Phospho-FRS2 (Tyr-349) Polyclonal Antibody

A1042-100
EUR 444

Frs2 sgRNA CRISPR Lentivector set (Mouse)

K3641401 3 x 1.0 ug
EUR 406.8

FRS2 sgRNA CRISPR Lentivector set (Human)

K0815201 3 x 1.0 ug
EUR 406.8

Frs2 sgRNA CRISPR Lentivector set (Rat)

K6479601 3 x 1.0 ug
EUR 406.8

Polyclonal Goat Anti-FRS2 Antibody (internal region)

APR16291G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-FRS2 (internal region). This antibody is tested and proven to work in the following applications:

FRS2 Colorimetric Cell-Based ELISA Kit (OKAG00728)

OKAG00728 96 Wells
EUR 715.2
Description: Description of target: ;Species reactivity: Human, Mouse;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: None
Detection Method: Colorimetric 450 nm;Sensitivity:

Frs2 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3641402 1.0 ug DNA
EUR 184.8

Frs2 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3641403 1.0 ug DNA
EUR 184.8

Frs2 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3641404 1.0 ug DNA
EUR 184.8

FRS2 sgRNA CRISPR Lentivector (Human) (Target 1)

K0815202 1.0 ug DNA
EUR 184.8

FRS2 sgRNA CRISPR Lentivector (Human) (Target 2)

K0815203 1.0 ug DNA
EUR 184.8

FRS2 sgRNA CRISPR Lentivector (Human) (Target 3)

K0815204 1.0 ug DNA
EUR 184.8

Frs2 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6479602 1.0 ug DNA
EUR 184.8

Frs2 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6479603 1.0 ug DNA
EUR 184.8

Frs2 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6479604 1.0 ug DNA
EUR 184.8

FRS2 Protein Vector (Human) (pPB-C-His)

PV016737 500 ng
EUR 394.8

FRS2 Protein Vector (Human) (pPB-N-His)

PV016738 500 ng
EUR 394.8

FRS2 Protein Vector (Human) (pPM-C-HA)

PV016739 500 ng
EUR 394.8

FRS2 Protein Vector (Human) (pPM-C-His)

PV016740 500 ng
EUR 394.8

FRS2 Protein Vector (Rat) (pPB-C-His)

PV269046 500 ng
EUR 723.6

FRS2 Protein Vector (Rat) (pPB-N-His)

PV269047 500 ng
EUR 723.6

FRS2 Protein Vector (Rat) (pPM-C-HA)

PV269048 500 ng
EUR 723.6

FRS2 Protein Vector (Rat) (pPM-C-His)

PV269049 500 ng
EUR 723.6

FRS2 Protein Vector (Mouse) (pPB-C-His)

PV180370 500 ng
EUR 723.6

FRS2 Protein Vector (Mouse) (pPB-N-His)

PV180371 500 ng
EUR 723.6

FRS2 Protein Vector (Mouse) (pPM-C-HA)

PV180372 500 ng
EUR 723.6

FRS2 Protein Vector (Mouse) (pPM-C-His)

PV180373 500 ng
EUR 723.6

Frs2 3'UTR Luciferase Stable Cell Line

TU204795 1.0 ml Ask for price

Frs2 3'UTR GFP Stable Cell Line

TU254795 1.0 ml Ask for price

Frs2 3'UTR GFP Stable Cell Line

TU156742 1.0 ml Ask for price

Frs2 3'UTR Luciferase Stable Cell Line

TU106742 1.0 ml Ask for price

FRS2 3'UTR GFP Stable Cell Line

TU058299 1.0 ml
EUR 2799.6

FRS2 3'UTR Luciferase Stable Cell Line

TU008299 1.0 ml
EUR 2799.6

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

20-abx104363
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

20-abx104364
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

20-abx104365
  • EUR 543.60
  • EUR 159.60
  • EUR 1562.40
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

20-abx133570
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

20-abx112531
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

20-abx012942
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

abx030590-400ul 400 ul
EUR 627.6

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

abx030590-80l 80 µl
EUR 343.2

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

abx036587-100ug 100 ug
EUR 469.2

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

abx233225-100ug 100 ug
EUR 577.2

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

abx331653-100ul 100 ul
EUR 510

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

abx431926-200ul 200 ul
EUR 460.8

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

20-abx301826
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

20-abx325550
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody

20-abx325634
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Monoclonal FRS2 Antibody (monoclonal) (M02), Clone: 1F7-1D6

APR16031G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human FRS2 (monoclonal) (M02). The antibodies are raised in Mouse and are from clone 1F7-1D6. This antibody is applicable in WB

FRS2 (Phospho-Tyr436) Colorimetric Cell-Based ELISA Kit

EKC2597 100ul
EUR 686.4

Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2)

4-RPC063Hu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor Receptor Substrate 2 expressed in: E.coli

Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2)

4-RPC063Mu01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibroblast Growth Factor Receptor Substrate 2 expressed in: E.coli

Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2)

4-RPC063Ra01
  • EUR 636.10
  • EUR 294.00
  • EUR 2055.36
  • EUR 765.12
  • EUR 1410.24
  • EUR 501.60
  • EUR 4958.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Fibroblast Growth Factor Receptor Substrate 2 expressed in: E.coli

Human Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Protein

20-abx066619
  • EUR 811.20
  • EUR 343.20
  • EUR 2498.40
  • EUR 961.20
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Protein

20-abx066620
  • EUR 878.40
  • EUR 343.20
  • EUR 2766.00
  • EUR 1062.00
  • EUR 627.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Protein

20-abx066621
  • EUR 828.00
  • EUR 343.20
  • EUR 2548.80
  • EUR 978.00
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Blocking Peptide

20-abx061152
  • EUR 343.20
  • EUR 510.00
  • 1 mg
  • 5 mg

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit

abx595239-96tests 96 tests
EUR 764.4

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody (HRP)

20-abx315732
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody (FITC)

20-abx315733
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Antibody (Biotin)

20-abx315734
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Phospho-FRS2 (Tyr436) Colorimetric Cell-Based ELISA Kit (OKAG02149)

OKAG02149 2 x 96 Wells
EUR 888
Description: Description of target: ;Species reactivity: Human: Y436, Mouse: Y436;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: Phospho
Detection Method: Colorimetric 450 nm;Sensitivity:

Mouse FRS2(Fibroblast Growth Factor Receptor Substrate 2) ELISA Kit

EM1034 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml

Human FRS2(Fibroblast Growth Factor Receptor Substrate 2) ELISA Kit

EH3084 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Mouse Fibroblast Growth Factor Receptor Substrate 2 (FRS2) CLIA Kit

abx196951-96tests 96 tests
EUR 990

Chicken Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit

abx356227-96tests 96 tests
EUR 990

Rabbit Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit

abx362533-96tests 96 tests
EUR 990

Sheep Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit

abx364732-96tests 96 tests
EUR 1111.2

Monkey Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit

abx359831-96tests 96 tests
EUR 990

Pig Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit

abx361590-96tests 96 tests
EUR 990

Human Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit

abx252483-96tests 96 tests
EUR 848.4

Mouse Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit

abx254085-96tests 96 tests
EUR 848.4

Frs2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K3641405 3 x 1.0 ug
EUR 451.2

FRS2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0815205 3 x 1.0 ug
EUR 451.2

Frs2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K6479605 3 x 1.0 ug
EUR 451.2

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Polyclonal Antibody (Mouse)

4-PAC063Mu01
  • EUR 301.20
  • EUR 3091.20
  • EUR 768.00
  • EUR 379.20
  • EUR 258.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibroblast Growth Factor Receptor Substrate 2 (FRS2)

Rat Fibroblast Growth Factor Receptor SubstRate 2(FRS2)ELISA Kit

QY-E10305 96T
EUR 433.2

Mouse Fibroblast Growth Factor Receptor SubstMousee 2(FRS2)ELISA Kit

QY-E20591 96T
EUR 433.2

ELISA kit for Human FRS2 (Fibroblast Growth Factor Receptor Substrate 2)

E-EL-H1120 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human FRS2 (Fibroblast Growth Factor Receptor Substrate 2) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse FRS2 (Fibroblast Growth Factor Receptor Substrate 2)

E-EL-M0502 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse FRS2 (Fibroblast Growth Factor Receptor Substrate 2) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Mouse FRS2 (Fibroblast Growth Factor Receptor Substrate 2)

E-CL-M0305 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Mouse FRS2 (Fibroblast Growth Factor Receptor Substrate 2) in samples from Serum, Plasma, Cell supernatant

Guinea pig Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit

abx357696-96tests 96 tests
EUR 990

Fibroblast Growth Factor Receptor Substrate 2 Phospho-Tyr436 (FRS2 pY436) Antibody

20-abx326292
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Frs2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K3641406 1.0 ug DNA
EUR 200.4

Frs2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K3641407 1.0 ug DNA
EUR 200.4

Frs2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K3641408 1.0 ug DNA
EUR 200.4

In addition, the application of MAPK inhibitors effectively increase the sensitivity of cells to pirarubicin RT112. In conclusion, the results of this study show that MKP-1 treatment resulted in bladder cancer cell chemoresistance through JNK, ERK and p38 pathways. MKP-1 can also serve as a potential therapeutic target for chemoresistance in patients with bladder cancer.