A point of view given Alzheimer’s disease (AD) as “type 3 diabetes” focuses on the central role of dysfunctional metabolism of cerebral energy in AD. The growth factor for hormonal fibroblasts 21 (FGF21) is a crucial regulator of energy metabolism; However, our understanding of the therapeutic potential and the mechanisms underlying the effect of the FGF21 on the neurodegeneration of advertising is far from complete.

Methods: To further elucidate the effect of FGF21 on AD-related neurodegeneration, we used transgenic mice APP / PS1 to evaluate the effects of the FGF21 on memory malfunction, the pathology of the amyloid plate and L ‘Pathological hyperphosphorylation of Tau. We have also established an in vitro system to imitate astrocyte-neuron communication and an in vivo model of acute injury. On the basis of in vivo and in vitro models, we analyzed the neuroprotective actions of FGF21 and channels relating to astrocyte-neuron communication and focused on the lactate astrocyte-neuron shuttle system.

Results: Here, we note that FGF21 can improve the neurodegeneration of an Alzheimer in transgenic mice app / ps1. We have detected defects in the lactate astrocyte-neuron shuttle system in AD vivo and in vitro models and identified FGF21 as a neuroprotective molecule that can save these deficits. The administration of FGF21 can attenuate the memory malfunction, the pathology of the amyloid plate and the pathological hythesis Tau, and the function of FGF21 in neurodegeneration is partly mediated by the monocarboxylate carriers (MCTs). In vivo, it is also suggested that FGF21 acts centrally in mice to effect on neurodegeneration and energy metabolism through its SCTM regulation.

Conclusions: These results suggest that the FGF21 modifies the metabolic parameters to mediate its neuroprotective functions. The modulation of the lactate astrocyte-neuron lactate shuttle system can be one of the most effective strategies for FGF21 in Alzheimer’s degeneration and helps to improve metabolic defects in the brain and cytotoxicity induced by the amyloid. Our conclusions provide information on the mechanisms underlying FGF21 on neurodegeneration and the metabolism of cerebral energy and suggest that FGF21 can have a therapeutic value in the treatment of advertising and other neurodegenerative diseases.

Therapeutic photobiomodulation improves the growth factor and the cytokine secretion profile in human type 2 diabetic fibroblasts

Cicatrization of altered wounds is a common complication of sweet diabetes (DM) and the underlying mechanism of this disability is still unclear. Fibroblast, as the main reconstructed cell, secretes critical growth factors and cytokine contributing to the healing of wounds. It is well known that DM modifies the behavior of these cells and photobiomodulation therapy (PBMT) compensates for certain deficiencies in diabetic fibroblasts.

As a result, the purpose of this study was to demonstrate the impact of diabetes and the role of PBMT by low-level laser irradiation on the secret profile of human diabetic fibroblasts. Primary human dermal fibers of normal donors and diabetics  were harvested. For PBMT, the DHDFs were irradiated with a 632.8 nm helium laser, wavelength and energy density of 0.5 J / cm2, as a laser-treated groupThen, certain cellular behaviors and a secretory profiling matrix for 60 growth factors / cytokines were studied in LT-DHDFS, and then compared to those of the controls.

The data showed that the PBMT could compensate for these deficiencies in DHDFs in terms of viability, proliferation and migration. In addition, taking into account our new conclusions, these 20 growth factors / cytokines involved in cell proliferation, the immune system regulation and cellular cell communication routes, which have decreased considerably in the DHDF compared to HDF, The PBMT could compensate seven in the LT-DHDFS compared to DHDFS.

The growth factor of the connective tissue produced by fibroblasts associated with cancer is correlated with a bad prognosis in a malignant pleural mesothelioma

Malignant mesothelioma is an aggressive neoplasm for which effective treatments are lacking. We often encounter cases of mesothelioma with a deep clever reaction, suggesting the involvement of fibroblasts associated with cancer (CAFS) in the progression of mesothelioma. While the roles of CAF have been widely studied in other tumors and have hoped that the cancer stroma contains heterogeneous caf populations, their roles in mesothelioma remain unknown.

We have previously shown that the conjunctive tissue growth factor (CTGF), a secreted protein, is produced by mesothelioma cells and fibroblasts and promotes invasion of in vitro mesothelioma cells. In this study, we examined the clinical relevance of CAFS in mesothelioma. Use of the surgical specimens of malignantly pleural mesothelioma, we evaluated the clinicopathological significance of the expression of α-smooth muscle actin (αsma), the most widely used marker of CAFs, the expression of the CTGF and the Extent of fibrosis by immunohistochemistry and masson coloration elastication.

Fibroblasts/Epithelial Cells Antibody (RPE)
abx413037-100tests	Abbexa	100 tests	EUR 811.2

Fibroblasts/Epithelial Cells Antibody (RPE)
abx413038-25tests	Abbexa	25 tests	EUR 427.2

Mouse Anti Human Fibroblasts/Epithelial Cells Monoclonal Antibody,RPE
DMABT-49595MH	Creative Diagnostics	25 TEST	EUR 514.8

Cartilage Dissociation System 1 (Mesenchymal, Fibroblasts, Epithelial-like), Mouse and Rat
4-20231	CHI Scientific	ea	Ask for price

Immortalized Human Pulmonary Fibroblasts Cells
T0490	ABM	1x106 cells / 1.0 ml	Ask for price

Retinal Pigment Epithelial Cells
RPE001	Neuromics	500,000 Cells	EUR 1545.6

Immortalized Human Cystic Fibrosis Tracheobronchial Epithelial Cells (CFT1)
T0681	ABM	1x106 cells / 1.0 ml	EUR 686.4

Epithelial Dissociation System 11 (Epithelial Cells), Mouse and Rat
4-20261	CHI Scientific	ea	Ask for price

Immortalized Human Lung Epithelial Cells
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Immortalized Human Renal Epithelial Cells
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Immortalized Human Mammary Epithelial Cells
T0450	ABM	1x106 cells / 1.0 ml	EUR 1243.2

Immortalized Human Corneal Epithelial Cells
T0572	ABM	1x106 cells / 1.0 ml	EUR 895.2

Immortalized Human Tracheal Epithelial Cells
T0489	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Human Prostate Epithelial Cells
T0600	ABM	1x106 cells / 1.0 ml	EUR 756

Immortalized Human Urethral Epithelial Cells
T0629	ABM	1x106 cells / 1.0 ml	Ask for price

Human Renal Proximal Tubule Epithelial Cells
SC00A1-PTEC	Neuromics	500,000 Cells	EUR 1585.2

Human Primary Mammary Epithelial Cells (HMEpC)
P0006038	Addexbio	One Frozen vial	EUR 600

Immortalized Human Lens Epithelial Cells - SV40
T0573	ABM	1x106 cells / 1.0 ml	EUR 895.2

Human Primary Colonic Epithelial cells (HCoEpC)
P0009028	Addexbio	One Frozen vial	EUR 650

Rat Thyroid PrimaCell: Thyroid Epithelial Cells
2-82598	CHI Scientific	1 Kit	Ask for price

Immortalized Human Nasal Epithelial Cells - SV40
T0440	ABM	1x106 cells / 1.0 ml	Ask for price

Human Primary Cervical Epithelial Cells (HCxEpC)
P0008008	Addexbio	One Frozen vial	EUR 650

Human Primary Prostate Epithelial Cells (HPrEpC)
P0019010	Addexbio	One Frozen vial	EUR 700

Mouse Thyroid PrimaCell: Thyroid Epithelial Cells
2-82103	CHI Scientific	1 Kit	Ask for price

Human Thyroid PrimaCell: Thyroid Epithelial Cells
2-96124	CHI Scientific	1 Kit	Ask for price

Immortalized Human Ovarian Epithelial Cells - SV40
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Immortalized Mouse Mammary Epithelial Cells (iMMEC)
T0451	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Human Amniotic Epithelial Cells - SV40
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Rat Eye PrimaCell4: Normal Lens Epithelial Cells
2-82541	CHI Scientific	1 Kit	Ask for price

Immortalized Human Pterygium Epithelial Cells - SV40
T0360	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Human Bronchial Epithelial Cells - SV40
T0486	ABM	1x106 cells / 1.0 ml	EUR 1243.2

Immortalized Human Placental Epithelial Cells - SV40
T0530	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Mouse Prostate Epithelial Cells (iMPEC)
T0607	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Human Renal Cortical Epithelial Cells
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Immortalized Human Bronchial Epithelial Cells (HBE1)
T0680	ABM	1x106 cells / 1.0 ml	EUR 686.4

Immortalized Human Retinal Pigment Epithelial Cells
T0571	ABM	1x106 cells / 1.0 ml	EUR 756

Immortalized Human Renal Medullary Epithelial Cells
T0615	ABM	1x106 cells / 1.0 ml	Ask for price

Mouse Eye PrimaCell4: Normal Lens Epithelial Cells
2-82040	CHI Scientific	1 Kit	Ask for price

Human Eye PrimaCell4: Normal Lens Epithelial Cells
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Immortalized Mouse Lung Epithelial Cells (MLE-15)
T0495	ABM	1x106 cells / 1.0 ml	EUR 686.4

Immortalized Human Conjuctival Epithelial Cells - SV40
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Immortalized Ovarian Surface Epithelial Cells (iMOSEC)
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Rat Eye PrimaCell2: Normal Corneal Epithelial Cells
2-82539	CHI Scientific	1 Kit	Ask for price

Immortalized Human Bronchial Epithelial Cells-hTERT
T0496	ABM	1x106 cells / 1.0 ml	EUR 1243.2

Rat Ureter PrimaCell: Normal Ureter Epithelial Cells
2-82588	CHI Scientific	1 Kit	Ask for price

Immortalized Human Mammary MUC+ESA+ Epithelial Cells
T0453	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Human Mammary Epithelial Cells (HMEC 2.6)
T0454	ABM	1x106 cells / 1.0 ml	EUR 1243.2

Rat Lung PrimaCell 7: Alveolar Epithelial Cells II
2-82596	CHI Scientific	1 Kit	Ask for price

Mouse Eye PrimaCell2: Normal Corneal Epithelial Cells
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Rat Kidney PrimaCell2: Normal Kidney Epithelial Cells
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Rat Ovary PrimaCell1: Normal Ovarian Epithelial Cells
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Human Eye PrimaCell2: Normal Corneal Epithelial Cells
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Immortalized Baby Mouse Kidney Epithelial Cells (iBMK)
T0082	ABM	1x106 cells / 1.0 ml	Ask for price

Mouse Ureter PrimaCell: Normal Ureter Epithelial Cells
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Rat Pancreas PrimaCell 2: Pancreatic Epithelial Cells
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Immortalized Human Small Airway Epithelial Cells - SV40
T0485	ABM	1x106 cells / 1.0 ml	EUR 1243.2

Mouse Lung PrimaCell 7: Alveolar Epithelial Cells II
2-82101	CHI Scientific	1 Kit	Ask for price

Human Lung PrimaCell 7: Alveolar Epithelial Cells II
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Rat Bladder PrimaCell1: Normal Bladder Epithelial Cells
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Human Airway PrimaCell1: Normal Airway Epithelial Cells
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Rat Colon PrimaCell1: Normal Colorectal Epithelial Cells
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Rat Prostate PrimaCell: Normal Prostate Epithelial Cells
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Rat Urethral PrimaCell: Normal Urethral Epithelial Cells
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Human Pancreas PrimaCell 2: Pancreatic Epithelial Cells
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Immortalized Rat Conjunctival Epithelial Cells (CJ4.1A) - SV40
T0368	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Rat Conjunctival Epithelial Cells (CJ4.3) - SV40
T0369	ABM	1x106 cells / 1.0 ml	Ask for price

Mouse Bladder PrimaCell1: Normal Bladder Epithelial Cells
2-82006	CHI Scientific	1 Kit	Ask for price

Mouse Cervix PrimaCell1: Normal Cervical Epithelial Cells
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Mouse Colon PrimaCell: Normal Colorectal Epithelial Cells
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Human Bladder PrimaCell1: Normal Bladder Epithelial Cells
2-96007	CHI Scientific	1 Kit	Ask for price

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2-96044	CHI Scientific	1 Kit	Ask for price

Human Colon PrimaCell: Normal Colorectal Epithelial Cells
2-96115	CHI Scientific	1 Kit	Ask for price

Immortalized Human Nasopharyngeal Epithelial Cells (NP69SV40T)
T0634	ABM	1x106 cells / 1.0 ml	Ask for price

Mouse Prostate PrimaCell: Normal Prostate Epithelial Cells
2-82083	CHI Scientific	1 Kit	Ask for price

Mouse Urethral PrimaCell: Normal Urethral Epithelial Cells
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Rat Cervix PrimaCell4: Normal Endometrial Epithelial Cells
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Human Prostate PrimaCell: Normal Prostate Epithelial Cells
2-96099	CHI Scientific	1 Kit	Ask for price

Human Urethral PrimaCell: Normal Urethral Epithelial Cells
2-96113	CHI Scientific	1 Kit	Ask for price

Immortalized Human Bronchial Epithelial Cells-hTERT/BMI
T0498	ABM	1x106 cells / 1.0 ml	EUR 1243.2

Immortalized Human Tonsillar Epithelial Cells (E6/E7 HTE)
T0660	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Human Bronchial Epithelial Cells-hTERT+CDK4
T0497	ABM	1x106 cells / 1.0 ml	EUR 1243.2

Immortalized Human Esophageal Epithelial Cells (NE2-hTERT)
T0632	ABM	1x106 cells / 1.0 ml	EUR 1243.2

Immortalized Human Mammary Epithelial Cells (HMEC 2.6) - SV40
T0455	ABM	1x106 cells / 1.0 ml	EUR 1243.2

Mouse Cervix PrimaCell4: Normal Endometrial Epithelial Cells
2-82026	CHI Scientific	1 Kit	Ask for price

Rat Esophagus PrimaCell1: Normal Esophageal Epithelial Cells
2-82536	CHI Scientific	1 Kit	Ask for price

Human Cervix PrimaCell4: Normal Endometrial Epithelial Cells
2-96047	CHI Scientific	1 Kit	Ask for price

Mouse Esophagus PrimaCell1: Normal Esophageal Epithelial Cells
2-82035	CHI Scientific	1 Kit	Ask for price

Human Esophagus PrimaCell1: Normal Esophageal Epithelial Cells
2-96055	CHI Scientific	1 Kit	Ask for price

Immortalized Human Nasopharyngeal Epithelial Cells (NPEC1/Bmi1)
T0765	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Human Nasopharyngeal Epithelial Cells (NPEC2/Bmi1)
T0766	ABM	1x106 cells / 1.0 ml	Ask for price

Rat Eye PrimaCell5: Normal Retinal Pigment Epithelial Cells
2-82542	CHI Scientific	1 Kit	Ask for price

Rat Kidney PrimaCell8: Normal Renal Tubular Epithelial Cells
2-82562	CHI Scientific	1 Kit	Ask for price

Mouse Eye PrimaCell5: Normal Retinal Pigment Epithelial Cells
2-82041	CHI Scientific	1 Kit	Ask for price

Rat Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells
2-82585	CHI Scientific	1 Kit	Ask for price

Human Eye PrimaCell5: Normal Retinal Pigment Epithelial Cells
2-96061	CHI Scientific	1 Kit	Ask for price

Mouse Kidney PrimaCell8: Normal Renal Tubular Epithelial Cells
2-82063	CHI Scientific	1 Kit	Ask for price

Human Kidney PrimaCell7: Normal Renal Tubular Epithelial Cells
2-96080	CHI Scientific	1 Kit	Ask for price

Immortalized Mouse Pancreas Epithelial Cells-Conditionally (IMPE)
T0156	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Mouse Colonic Epithelial Cells-Conditionally (YAMC)
T0567	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Mouse Stomach Epithelial Cells-Conditionally (ImSt)
T0569	ABM	1x106 cells / 1.0 ml	Ask for price

Mouse Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells
2-82088	CHI Scientific	1 Kit	Ask for price

Human Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells
2-96104	CHI Scientific	1 Kit	Ask for price

Rat Eye PrimaCell4: Normal Lens Epithelial Cells Growth Medium
9-25041	CHI Scientific	5 x 100 ml	Ask for price

Mouse Eye PrimaCell4: Normal Lens Epithelial Cells Growth Medium
9-32040	CHI Scientific	5 x 100 ml	Ask for price

Human Eye PrimaCell4: Normal Lens Epithelial Cells Growth Medium
9-46060	CHI Scientific	5 x 100 ml	Ask for price

Immortalized Human Endocervical Epithelial Cells- HPV E6/E7 (A2EN)
T0595	ABM	1x106 cells / 1.0 ml	EUR 825.6

Rat Intestine PrimaCell1: Normal Intestinal Mucosa Epithelial Cells
2-82552	CHI Scientific	1 Kit	Ask for price

Rat Eye PrimaCell2: Normal Corneal Epithelial Cells Growth Medium
9-25039	CHI Scientific	5 x 100 ml	Ask for price

Rat Ureter PrimaCell: Normal Ureter Epithelial Cells Growth Medium
9-25088	CHI Scientific	5 x 100 ml	Ask for price

Immortalized Mouse Retinal Pigmented Epithelial Cells - HPV16 E6/E7
T0574	ABM	1x106 cells / 1.0 ml	Ask for price

Mouse Intestine PrimaCell3: Normal Intestinal Mucosa Epithelial Cells
2-82053	CHI Scientific	1 Kit	Ask for price

Human Intestine PrimaCell1: Normal Intestinal Mucosa Epithelial Cells
2-96071	CHI Scientific	1 Kit	Ask for price

Rat Kidney PrimaCell2: Normal Kidney Epithelial Cells Growth Medium
9-25056	CHI Scientific	5 x 100 ml	Ask for price

Rat Ovary PrimaCell1: Normal Ovarian Epithelial Cells Growth Medium
9-25076	CHI Scientific	5 x 100 ml	Ask for price

Rat Thyroid PrimaCell: Normal Thyroid Epithelial Cells Growth Medium
9-25098	CHI Scientific	5 x 100 ml	Ask for price

Mouse Eye PrimaCell2: Normal Corneal Epithelial Cells Growth Medium
9-32038	CHI Scientific	5 x 100 ml	Ask for price

Mouse Ureter PrimaCell: Normal Ureter Epithelial Cells Growth Medium
9-32092	CHI Scientific	5 x 100 ml	Ask for price

Human Eye PrimaCell2: Normal Corneal Epithelial Cells Growth Medium
9-46058	CHI Scientific	5 x 100 ml	Ask for price

Rat Ureter Tissue Preparation Buffer: Normal Ureter Epithelial Cells
9-80295	CHI Scientific	1 x 100 ml	Ask for price

Rat Eye Tissue Preparation Buffer 4: Normal Lens Epithelial Cells
9-80248	CHI Scientific	1 x 100 ml	Ask for price

Rat Airway PrimaCell1: Normal Bronchial and Tracheal Epithelial Cells
2-82501	CHI Scientific	1 Kit	Ask for price

Rat Bladder PrimaCell1: Normal Bladder Epithelial Cells Growth Medium
9-25006	CHI Scientific	5 x 100 ml	Ask for price

Rat Cervix PrimaCell1: Normal Cervical Epithelial Cells Growth Medium
9-25024	CHI Scientific	5 x 100 ml	Ask for price

Rat Colon PrimaCell1: Normal Colorectal Epithelial Cells Growth Medium
9-25029	CHI Scientific	5 x 100 ml	Ask for price

Rat Prostate PrimaCell: Normal Prostate Epithelial Cells Growth Medium
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Rat Urethral PrimaCell: Normal Urethral Epithelial Cells Growth Medium
9-25089	CHI Scientific	5 x 100 ml	Ask for price

Mouse Kidney PrimaCell2: Normal Kidney Epithelial Cells Growth Medium
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Mouse Ovary PrimaCell1: Normal Ovarian Epithelial Cells Growth Medium
9-32077	CHI Scientific	5 x 100 ml	Ask for price

Mouse Thyroid PrimaCell: Normal Thyroid Epithelial Cells Growth Medium
9-32103	CHI Scientific	5 x 100 ml	Ask for price

Human Airway PrimaCell1: Normal Airway Epithelial Cells Growth Medium
9-46001	CHI Scientific	5 x 100 ml	Ask for price

Human Kidney PrimaCell2: Normal Kidney Epithelial Cells Growth Medium
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Human Ovary PrimaCell1: Normal Ovarian Epithelial Cells Growth Medium
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Human Ureter PrimaCell2: Normal Ureter Epithelial Cells Growth Medium
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Human Thyroid PrimaCell: Normal Thyroid Epithelial Cells Growth Medium
9-46124	CHI Scientific	5 x 100 ml	Ask for price

Mouse Ureter Tissue Preparation Buffer: Normal Ureter Epithelial Cells
9-80206	CHI Scientific	1 x 100 ml	Ask for price

Rat Thyroid Tissue Preparation Buffer: Normal Thyroid Epithelial Cells
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We also analyzed the expression of the paralague of the stroach cells and the mesenchymate fibroblast, a recently reported CAF marker which labels cancer cafs and differs from the positive coffees of αsma, by hybridization in situ. The extent of fibrosis and the expression of the CTGF in mesothelioma cells are not correlated with the patient’s prognosis. However, the expression of αsma and the CTGF, but not Meflin, in CAF correlated with a bad prognosis. The data suggest that CTGF + CAF are involved in the progression of mesothelioma and represent a potential molecular target for mesothelioma therapy.